In collaboration with Consulting Editor, Dr. Norman Gitlin, Dr. Steven Flamm has put together another great update for the hepatology consult. Articles are submitted by expert author and in the format of the clinical review article, provide timely data for diagnosis and treatment. Specific areas addressed include the following: Management of esophageal and gastric varices; Severe thrombocytopenia in chronic liver disease and new management approaches; Pathology in chronic liver disease; Alpha 1 antitrypsin disease and chronic liver disease in adults; Evaluation of management of Budd-Chiari; HBV reactivation with immunosuppressive therapy; Homeopathic products and hepatotoxicity; New uses of TIPS; Dermatologic manifestations of chronic liver disease; Acute on chronic liver failure; Cholangiocarcinoma; Diagnosis and management of hepatic adenoma and focal nodular hyperplasia; Emerging data about the microbiome in chronic liver disease; and Acute viral hepatitis aside from HAV, HBV, and HCV. Readers will come away with the information they need to improve patient outcomes.

In collaboration with Consulting Editor, Dr. Norman Gitlin, Dr. Pierre Gholam has put together topics that provide a current clinical update on the treatment and management of patients with drug-induced liver injury (DILI). Expert authors have contributed clinical review articles on the following topics: Epidemiology, Predisposing Factors and Outcomes; Genetic Predisposition to DILI; Causality Assessment Frequent Offenders and Patterns of Injury; Quantitative Systems Toxicology Approaches to Understand and Predict DILI; Liver Histology: Diagnostic and Prognostic Features; Acute Liver Failure Secondary to DILI; DILI in Persons with Pre-existing Chronic Liver Disease; DILI in the Setting of Statin Use; DILI in the Setting of Analgesic Use; DILI Secondary to Herbals and Dietary Supplements; and DILI Reporting and Resources for the Clinician. Readers will come away with the information they need to improve outcomes in patients with DILI.

In this issue, guest editors bring their considerable expertise to this important topic. Provides in-depth reviews on the latest updates in the field, providing actionable insights for clinical practice. Presents the latest information on this timely, focused topic under the leadership of experienced editors in the field. Authors synthesize and distill the latest research and practice guidelines to create these timely topic-based reviews.

In this issue of Clinics in Liver Disease, guest editor Dr. John V. Binu brings his considerable expertise to the topic of Primary Biliary Cholangitis. PBC leads to inflammation and scarring of the small bile ducts, and, if untreated, can lead to cirrhosis and liver failure. In this issue, top experts provide a state-of-the-art review of diagnosis and treatment for this chronic, progressive liver disorder. Contains 13 practice-oriented topics including genetics of primary biliary cholangitis; prognostic scoring systems in PBC; overlap syndromes and PBC; non-invasive evaluation of fibrosis and portal hypertension in PBC; treatment of PBC: first- and second-line therapies; novel therapies for PBC; and more. Provides in-depth clinical reviews on primary biliary cholangitis, offering actionable insights for clinical practice. Presents the latest information on this timely, focused topic under the leadership of experienced editors in the field. Authors synthesize and distill the latest research and practice guidelines to create clinically significant, topic-based reviews.

With collaboration from Consulting Editor, Dr. Norman Gitlin Dr. Goldberg has assembled a state-of-the-art issue devoted to management of liver transplant patients. Expert authors have contributed current clinical reviews that covers the breadth of the pre- and post-surgical journey. Articles are specifically devoted to the following topics: Obesity management of liver transplant waitlist candidates and recipients; Expanding the limits of liver transplantation for hepatocellular carcinoma: Is there a limit; Frailty and sarcopenia in patients pre- and post-liver transplant; Achieving tolerance in liver transplantation: Where are we now and what does the future hold; Expanding role of donation after cardiac death donors; Optimizing selection of patients for simultaneous liver-kidney transplant; Keeping the patient with end-stage liver disease alive while awaiting transplant: Management of complications of portal hypertension; Expanding donor selection and recipient indications for living donor liver transplantation; The changing liver transplant recipient: From hepatitis C to NASH and alcohol; Cardiovascular risk stratification in liver transplant candidates; The role of machine perfusion in liver transplantation: Warm, Cold, or does it not matter; Paradigm shift in utilization of livers from hepatitis C-viremic donors into HCV-negative patients; Transplantation of elderly patients: Is there an upper age cutoff; Transplantation for acute alcoholic hepatitis: Controversies and early successes. Hepatologists will come away with the information they need to improve outcomes in liver transplant patients.

In collaboration with Consulting Editor, Dr. Norman Gitlin, Guest Editors Drs. Andres Cardenas and Thomas Reiberger have created an up-to-date monograph on the complications of cirrhosis. They have secured top experts to contribute clinical review articles on the following topics: Non-invasive Detection of CSPH in cACLD; Prevention of First Decompensation in ACLD; Treatment of Acute Variceal Bleeding in 2020: When to Use TIPS; Prevention of Variceal Bleeding and Rebleeding by NSBB: A Tailored Approach; The Role of Hepatic Venous Pressure Gradient (HVPG); Measurement in the Management of Cirrhosis; Bacterial Infections in Cirrhosis as a Cause or Consequence of Decompensation; Nutrition in Chronic Liver Disease; Diagnosis and Management of Hepatic Encephalopathy; Discriminating Acute Decompensation from Acute-on-Chronic Liver; Management of Severe and Refractory Ascites; Monitoring Renal Function and Therapy of HRS patients with Cirrhosis; Coagulopathy in Cirrhosis; and Current Concepts of Cirrhotic Cardiomyopathy. Hepatologists will come away with the information they need to manage these patients.

In this issue of Clinics in Liver Disease, Guest Editor Paul Kwo brings his considerable expertise to the topic of Alcoholic Hepatitis. Top experts in the field cover key topics such as the Epidemiology of Alcoholic Hepatitis, Nutrition in Those with Alcoholic Hepatitis, Current therapies for alcoholic hepatitis, Selection Criteria for Liver Transplantation for Acute Alcoholic Hepatitis, and more. - Provides in-depth, clinical reviews on Alcoholic Hepatitis, providing actionable insights for clinical practice. - Presents the latest information on this timely, focused topic under the leadership of experienced editors in the field; Authors synthesize and distill the latest research and practice guidelines to create these timely topic-based reviews. - Contains 11 relevant, practice-oriented topics including Emerging Therapies for alcoholic hepatitis; Diagnosis of Alcoholic Hepatitis; Moderate Alcoholic Hepatitis; Current and Future Biomarkers in Alcoholic Hepatitis, and more.

In this issue of Clinics in Liver Disease, guest editor Dr. Sammy Saab brings his considerable expertise to the topic of Hepatic Encephalopathy. Hepatic encephalopathy (HE) is a reversible syndrome in patients with advanced liver dysfunction, and is characterized by a wide spectrum of neuropsychiatric abnormalities resulting from the accumulation of neurotoxic substances in the brain. In this issue, top experts provide detailed clinical reviews devoted to the epidemiology, manifestations, and management of HE in the hopes of improving patient outcomes. - Contains 13 relevant, practice-oriented topics including clinical manifestations of HE; laboratory abnormalities of HE; pharmacologic management of HE; nontraditional treatment of HE; social impact of HE; future therapies of HE; and more. - Provides in-depth clinical reviews on hepatic encephalopathy, offering actionable insights for clinical practice. - Presents the latest information on this timely, focused topic under the leadership of experienced editors in the field. Authors synthesize and distill the latest research and practice guidelines to create clinically significant, topic-based reviews.

In this issue of Clinics in Liver Disease, guest editor Dr. Nikolaos T. Pyrsopoulos brings his considerable expertise to the topic of Acute-on-Chronic Liver Failure. Recent studies indicate that as many as one in four patients with cirrhosis develop acute-on-chronic liver failure (ACLF) and 25% die within one month. This issue, the first devoted to this topic, provides thorough coverage of critical clinical interventions, including diagnosis, treatment, and management. It also focuses on early recognition of ACLF, which is important for the initiation of aggressive management and ultimately, saving lives. Contains 17 practice-oriented topics including ACLF: mechanisms of disease and multisystemic involvement; the clinical spectrum and manifestations of ACLF; management of ACLF; maximizing the donor potential for patients with ACLF Listed for Liver Transplant; future approaches and therapeutic modalities for ACLF; and more. Provides in-depth clinical reviews of acute-on-chronic liver failure, offering actionable insights for clinical practice. Presents the latest information on this timely, focused topic under the leadership of experienced editors in the field. Authors synthesize and distill the latest research and practice guidelines to create clinically significant, topic-based reviews.

In this issue, guest editors bring their considerable expertise to this important topic. Contains 20 practice-oriented topics, including metabolic syndrome associated with NASH; genetic markers and comorbidities predisposing to NASH and progressive liver disease; the role of bariatric surgery and endobariatric surgery in NASH; future treatment options and regimens for NAFLD; and more. Provides in-depth clinical reviews on non-alcoholic steatohepatitis, offering actionable insights for clinical practice. Presents the latest information on this timely, focused topic under the leadership of experienced editors in the field. Authors synthesize and distill the latest research and practice guidelines to create clinically significant, topic-based reviews.