Although COVID-19 full prime vaccination generates immunity against severe and life-threatening infections, there are still cases of breakthrough infections. This might be due to several causes — such as the fact that full prime vaccination might not generate enough immunity; that immunity wanes over time; or that the elderly, immunocompromised, transplant recipients and people with underlying diseases could suffer severe infections regardless of vaccination. Moreover, emerging new variants of concern (such as Delta or Omicron) that are highly infective and evade immunity could increase breakthrough infection. Booster shots could increase immunity and reduce the likelihood of having severe COVID and post-COVID-19 (long COVID). Immunocompromised or transplant recipients could generate immunity after booster shots even if they did not develop immunity after full prime. Moreover, booster shots not only protect vaccinated individuals, but they could also reduce the impact on lifestyle, public health and economics. This research topic aims to focus on the effect of COVID-19 booster shots and the evidence seen in animal models, clinical trials, real-world evidence, and systematic reviews.

**Textbook and Academic Authors Association (TAA) Textbook Excellence Award Winner, 2024** Prepare for Canadian nursing practice with a solid understanding of pathophysiology and disease! Huether and McCance's Understanding Pathophysiology, 2nd Canadian Edition covers the basic concepts of pathophysiology and disease processes from a Canadian perspective. Clear descriptions and vibrant illustrations make it easier to understand body systems and the mechanisms of disease, and online resources bring pathophysiology concepts to life. Developed for Canadian nursing students by educators Kelly Power-Kean, Stephanie Zettel, and Mohamed Toufic El-Hussein, this text prepares students for success on the Next Generation NCLEX®, CPNRE®, and REx-PNTM and also in clinical practice. - Introduction to Pathophysiology provides an entrance to the science of pathophysiology and explains why it is important. - Lifespan coverage includes nine separate chapters on developmental alterations in pathophysiology and special sections with aging and pediatrics content. - Canadian drug and treatment guidelines familiarize you with aspects of clinical practice you will encounter. - Coverage of diseases includes their pathophysiology, clinical manifestations, and evaluation and treatment. - Canadian lab values provide the core fundamental information required for practice in Canada. - Canadian morbidity statistics provide you with the Canadian context in which you will be practising. - Algorithms and flowcharts of diseases and disorders make it easy to follow the sequential progression of disease processes. - Health Promotion boxes emphasize evidence-based care and align with the Canadian curriculum. - Risk Factors boxes highlight important safety considerations associated with specific diseases. - Quick Check boxes test your understanding of important chapter concepts. - End-of-chapter Did You Understand? summaries make it easy to review the chapter's major concepts. - Key Terms are set in blue, boldface type and listed at the end of each chapter - Glossary of approximately 1,000 terms is included on the Evolve website with definitions of important terminology.

Gain an in-depth understanding of the concepts and processes of disease! Understanding Pathophysiology, 8th Edition provides a concise, comprehensive introduction to the way diseases work and how changes occur in the body as a result. With a clinically focused approach, the book begins by explaining cell structure and function. It then examines alterations by body systems and provides a practical guide to clinical manifestations, summaries of treatment, and health promotion strategies. This edition adds new algorithms, case studies for the Next-Generation NCLEX® Exam, and updated content on COVID-19, obesity, and cancer epidemiology. Written by a team of nursing educators led by Sue Huether, this text helps you develop clinical judgment and apply concepts to practice. - NEW! Case studies for the Next-Generation NCLEX® Exam (NGN) are provided on the Evolve website, helping you develop clinical judgment. - NEW! Content updates address infectious disease, COVID-19 and post-COVID conditions, systemic pathophysiologic effects of obesity, cancer epidemiology, and more. - NEW! Additional new algorithms show the pathophysiologic pathways and progression of disease. - Consistent presentation of each disease includes pathophysiology, clinical manifestations, and evaluation and treatment. - Lifespan content includes nine separate chapters with pediatric content and special sections on aging within the adult chapters, along with special boxes that highlight aging and pediatric content. - More than 1000 illustrations include photographs showing pathologic features of disease as well as micrographs showing normal and abnormal cellular structure. - Risk Factor boxes show how certain risk factors are associated with specific diseases. - Quick Check boxes appear at the end of major sections and are designed to help you recall the most important content. - End-of-chapter Summary Reviews highlight the major concepts presented in each chapter. - Did You Know boxes discuss new developments in biologic research, diagnostic studies, preventive care, treatments, and more. - Key Terms are bolded, and listed with page numbers at the end of each chapter. - Student resources on Evolve include animations, review questions, chapter summaries, and answers to the Quick Check questions.

The role of vaccines is emerging and even critical to ending infectious and chronic diseases and pandemics alike. The design and development of new vaccines could lead to improved health. Handbook on Advanced Vaccination Technologies for Infectious and Chronic Disease discusses these new developments and introduces the reader to the current state of the science and the outlook going forward from the discovery of vaccines to the clinical trials of personalized vaccines. Handbook on Advanced Vaccination Technologies for Infectious and Chronic Diseases is a valuable reference for occupational health professionals whose role involves supervision of immunization programs such as those working in the National Health Service, some sectors of higher education and the pharmaceutical industry. - Offers comprehensive coverage of different vaccine platforms and their development - Includes information on the regulatory perspective of vaccine development - Describes different delivery approaches for vaccinology - Explains the clinical development of vaccines along with novel platforms - Covers all recent developments of vaccine production technologies, new types of vaccines, and ongoing research that could prevent future pandemics

The essential textbook for HIV care providers and pharmacists--updated for 2023! Fundamentals of HIV Medicine has served as a key resource for clinicians preventing and treating HIV for over a decade. An end-to-end clinical resource for the treatment of individuals with HIV/AIDS, Fundamentals of HIV Medicine 2023 offers practitioners immediate, indexed access to the most recent science, research, and guidelines related to all aspects of HIV care and prevention. Now updated to reflect the convergent knowledge at the intersection of two global pandemics, HIV and COVID-19, Fundamentals of HIV Medicine 2023 offers state-of-the-art continuing education for physicians, pharmacists, nurse practitioners, physician assistants, nurses, and other professionals working in the care of HIV patients. This revised edition features key clinical updates across classic domains of HIV medicine along with new understandings of injectable antiretroviral treatment and explorations into concepts of HIV latency for long-term viral remission. Embodying the American Academy of HIV Medicine's commitment to excellence in the care of seropositive patients, Fundamentals of HIV Medicine 2023 is a must-have for health professionals across HIV care, treatment, and prevention.

Senator Rand Paul was on to Anthony Fauci from the start. Wielding previously unimaginable power, Fauci misled the country about the origins of the Covid pandemic and shut down scientific dissent. One of the few leaders who dared to challenge "America’s Doctor" was Senator Rand Paul, himself a physician. Deception is his indictment of the catastrophic failures of the public health bureaucracy during the pandemic. Senator Paul presents the evidence that: The Covid virus was likely the product of gain-of-function research at the Wuhan lab in China—research funded in part by the U.S. government. Taxpayer dollars for that research were deceptively funneled to Wuhan without the required regulatory review. Fauci and his scientific yes-men knew from day one about Covid’s origin and tried to cover it up. Fauci and his allies ruthlessly attacked everyone—including highly qualified scientists—who threatened to reveal the truth about the pandemic. Why? Hundreds of millions of dollars of grants and unreported royalties were at stake, and heads would roll if the truth got out. It almost worked. At Fauci’s insistence, the government imposed needlessly extreme lockdowns on Americans at the cost of immense personal and economic destruction. Covid-19 was deadly, but the real killer was the coverup, led by America’s most durable medical bureaucrat—a man for whom the truth was too often expendable. Senator Paul makes a powerful case that funding dangerous bioengineering in a totalitarian country is madness. If we don’t heed this warning, the next pandemic could be far worse.

The Handbook of Systemic Drug Treatment in Dermatology helps prescribers and patients make rational decisions about drug treatment while considering known risks and potential unwanted effects. Written for dermatologists, family practitioners, pharmacists and specialist nurses, this completely revised and updated third edition of a bestseller provides an accessible and concise aid to prescribing and monitoring systemic dermatologic therapy. For each drug or drug class, the book lists its classification, mode of action, formulations, dosages, suggested regimens, contraindications, important drug interactions, adverse effects, patient information, and more. This third edition includes new classes of drugs as well as information on updated guidelines for prescribing and monitoring established drugs. FROM REVIEWS OF PREVIOUS EDITIONS "This updated edition includes new arrivals... Quite simply, it is indispensable! I have it with me in every clinic and often refer to it in discussions with pharmacists (who have been known to borrow my copy and forget to return it)." Dermatology in Practice "... an outstanding resource that helps to alleviate worrying by providing precise guidelines and advice in managing our most infirm patients who require these medications." SkinMed