The study of defects and disorder in solids remains a central topic in solid state science. Developments in the field continue to be promoted by new experimental and theoretical techniques, while further impetus for the study of disorder in solids is provided by the growing range of applications of solid state materials in which disorder at the atomic level plays a crucial rOle. In this book we attempt to present a survey of fundamental and applied aspects of the field. We consider the basic aspects of defective crystalline and amorphous solids. We discuss recent studies of structural, electronic, transport, thermodynamic and spectroscopic properties of such materials. Experimental and theoretical methodologies are reviewed, and detailed consideration is given to materials such as fast ion conductors and amorphous semiconductors that are of importance in an applied context. Any survey of this large field is necessarily selective. We have chosen to emphasise insulating (especially oxidic) and semi-conducting materials. But many of the approaches and techniques we describe apply generally across the entire field of solid state science. This volume is based on a NATO ASI held at the Residencia Santa Teresa de Jesus, Madrid in September 1991. The Editor is grateful to the NATO Scientific Affairs Division for their sponsorship of this School. Thanks are also due to all who participated in and lectured at the school, but especially to the organising committee of A. V. Chadwick, G. N. Greaves, M. Grigorkiewicz, J. H. Harding and S. Kalbitzer. C. R. A.

Presents a detailed discussion of important solid-state properties, methods, and applications of solid-state analysis Illustrates the various phases or forms that solids can assume and discussesvarious issues related to the relative stability of solid forms and tendencies to undergo transformation Covers key methods of solid state analysis including X-ray powder diffraction, thermal analysis, microscopy, spectroscopy, and solid state NMR Reviews critical physical attributes of pharmaceutical materials, mainly related to drug substances, including particle size/surface area, hygroscopicity, mechanical properties, solubility, and physical and chemical stability Showcases the application of solid state material science in rational selection of drug solid forms, analysis of various solid forms within drug substance and the drug product, and pharmaceutical product development Introduces appropriate manufacturing and control procedures using Quality by Design, and other strategies that lead to safe and effective products with a minimum of resources and time

A one-stop resource for researchers, developers, and post graduate students in pharmaceutical science. This handbook and ready reference provides detailed, but not overloaded information -- presenting the topic without unnecessarily complex formalism. As such, it gives a systematic and coherent overview of disordered materials for pharmaceutical applications, covering fundamental aspects, as well as preparation and characterization techniques for the target-oriented development of drug delivery systems based on disordered crystals and amorphous solids. Special attention is paid to examine the different facets and levels of disorder in their structural and dynamic aspects as well as the effect of disorder on dissolution and stability. Chapters on processing induced disorder and on patenting issues round off the book. As a result the book helps overcoming the challenges of using these materials in the pharmaceutical industry. For pharmaceutical and medicinal chemists, materials scientists, clinical physicists, and pharmaceutical laboratories looking to make better and more potent pharmaceuticals.

Proceedings of IAU Symposium No. 90 organized by IAU in co-operation with COSPAR held in Ottawa, Canada, August 27-30, 1979

The subject of low-energy excitations has evolved since two-level-tunneling systems were first proposed ~50 years ago. Initially they were used to explain the common anomalous properties of oxide glasses and polymers; now the subject includes a wide range of other materials containing disorder: amorphous semiconductors and metals, doped- mixed- and quasi-crystals, surface adsorbates, ... and topics such as dephasing of quantum states and interferometer noise. A fairly simple empirical description using a remarkably small range of parameters serves well to describe the effect of these excitations, but the structures causing these effects are known in only a few materials and the reasons for their similarity across disparate materials has only been qualitatively addressed.This book provides a unified, comprehensive description of tunneling systems in disordered solids suitable for graduate students/researchers wishing an introduction to the field. Its focus is on the tunneling systems intrinsic to glassy solids. It describes the experimental observations of 'glassy' properties, develops the basic empirical tunneling model, and discusses the dynamics changes on cooling to temperatures where direct excitation interactions become important and on heating to where tunneling gives way to thermal activation. Finally, it discusses how theories of glass formation can help us understand the ubiquity of these excitations.The Development of the basic tunneling model is the core of the book and is worked out in considerable detail. To keep the total within bounds of our expertise and the readers' patience, many related experimental and theoretical developments are only sketched out here; the text is heavily cited to allow readers to follow their specific interests in much more depth.

This new book explores the consideration of relationships that connect the structural and basic mechanical properties of polymeric mediums within the frameworks of fractal analysis with cluster model representations attraction. Incidentally, the choice of any structural model of medium or their combinations is defined by expediency and further usag

This book presents the method of ion beam modification of solids in realization, theory and applications in a comprehensive way. It provides a review of the physical basics of ion-solid interaction and on ion-beam induced structural modifications of solids. Ion beams are widely used to modify the physical properties of materials. A complete theory of ion stopping in matter and the calculation of the energy loss due to nuclear and electronic interactions are presented including the effect of ion channeling. To explain structural modifications due to high electronic excitations, different concepts are presented with special emphasis on the thermal spike model. Furthermore, general concepts of damage evolution as a function of ion mass, ion fluence, ion flux and temperature are described in detail and their limits and applicability are discussed. The effect of nuclear and electronic energy loss on structural modifications of solids such as damage formation, phase transitions and amorphization is reviewed for insulators and semiconductors. Finally some selected applications of ion beams are given.

The Encyclopedia of Physical Chemistry and Chemical Physics introduces possibly unfamiliar areas, explains important experimental and computational techniques, and describes modern endeavors. The encyclopedia quickly provides the basics, defines the scope of each subdiscipline, and indicates where to go for a more complete and detailed explanation. Particular attention has been paid to symbols and abbreviations to make this a user-friendly encyclopedia. Care has been taken to ensure that the reading level is suitable for the trained chemist or physicist. The encyclopedia is divided in three major sections: FUNDAMENTALS: the mechanics of atoms and molecules and their interactions, the macroscopic and statistical description of systems at equilibrium, and the basic ways of treating reacting systems. The contributions in this section assume a somewhat less sophisticated audience than the two subsequent sections. At least a portion of each article inevitably covers material that might also be found in a modern, undergraduate physical chemistry text. METHODS: the instrumentation and fundamental theory employed in the major spectroscopic techniques, the experimental means for characterizing materials, the instrumentation and basic theory employed in the study of chemical kinetics, and the computational techniques used to predict the static and dynamic properties of materials. APPLICATIONS: specific topics of current interest and intensive research. For the practicing physicist or chemist, this encyclopedia is the place to start when confronted with a new problem or when the techniques of an unfamiliar area might be exploited. For a graduate student in chemistry or physics, the encyclopedia gives a synopsis of the basics and an overview of the range of activities in which physical principles are applied to chemical problems. It will lead any of these groups to the salient points of a new field as rapidly as possible and gives pointers as to where to read about the topic in more detail.

This book introduces the spectral approach to transport problems in infinite disordered systems characterized by Anderson-type Hamiltonians. The spectral approach determines (with probability one) the existence of extended states for nonzero disorder in infinite lattices of any dimension and geometry. Here, the author focuses on the critical 2D case, where previous numerical and experimental results have shown disagreement with theory. Not being based on scaling theory, the proposed method avoids issues related to boundary conditions and provides an alternative approach to transport problems where interaction with various types of disorder is considered. Beginning with a general overview of Anderson-type transport problems and their relevance to physical systems, it goes on to discuss in more detail the most relevant theoretical, numerical, and experimental developments in this field of research. The mathematical formulation of the innovative spectral approach is introduced together with a physical interpretation and discussion of its applicability to physical systems, followed by a numerical study of delocalization in the 2D disordered honeycomb, triangular, and square lattices. Transport in the 2D honeycomb lattice with substitutional disorder is investigated employing a spectral analysis of the quantum percolation problem. Next, the applicability of the method is extended to the classical regime, with an examination of diffusion of lattice waves in 2D disordered complex plasma crystals, along with discussion of proposed future developments in the study of complex transport problems using spectral theory.