This volume focuses on the etiology and morphogenesis of congenital heart diseases. It reviews in detail the early development and differentiation of the heart, and later morphologic events of the cardiovascular system, covering a wide range of topics such as gene functions, growth factors, transcription factors and cellular interactions that are implicated in cardiac morphogenesis and congenital heart disease. This book also presents recent advances in stem cell and cell sheet tissue engineering technologies which have the potential to provide novel in vitro disease models and to generate regenerative paradigms for cardiac repair and regeneration. This is the ideal resource for physician scientists and investigators looking for updates on recent investigations on the origins of congenital heart disease and potential future therapies.

Due to population aging, calcific aortic valve disease (CAVD) has become the most common heart valve disease in Western countries. No therapies exist to slow this disease progression, and surgical valve replacement is the only effective treatment. Calcific Aortic Valve Disease covers the contemporary understanding of basic valve biology and the mechanisms of CAVD, provides novel insights into the genetics, proteomics, and metabolomics of CAVD, depicts new strategies in heart valve tissue engineering and regenerative medicine, and explores current treatment approaches. As we are on the verge of understanding the mechanisms of CAVD, we hope that this book will enable readers to comprehend our current knowledge and focus on the possibility of preventing disease progression in the future.

Notch signaling is an evolutionarily conserved pathway in multicellular organisms that regulates cell-fate determination during development and in stem cells. This volume, which is part of the Current Topics in Developmental Biology series, covers topics such as Notch signaling in cardiac development and disease and Notch in stem cells. International authors provide researchers with an overview and synthesis of the latest research findings and contemporary thought in the area. - Covers topics such as Notch signaling in cardiac development and disease, and Notch in stem cells - International authors provide researchers with an overview and synthesis of the latest research findings and contemporary thought in the area

"Circulating Through the Aortic Valve: Understanding, Managing, and Innovating in Aortic Valve Stenosis" is a comprehensive treatise that delves into the intricate world of Aortic Valve Stenosis (AS), a significant cardiovascular condition affecting millions worldwide. This extensive exploration navigates through the historical roots of our understanding, providing a nuanced overview of the condition's epidemiology, prevalence, and the structural and functional intricacies of the aortic valve. The treatise meticulously dissects the etiology and causes of AS, unraveling the hemodynamic consequences and delving into the cellular and molecular mechanisms driving its progression. From symptoms and signs to the grading of severity, the work navigates through the clinical landscape, aiding in a thorough understanding and differential diagnosis of AS.

Porth Pathophysiology: understanding made easy, delivered however you need it. Porth's "Essentials of Pathophysiology" 3e delivers exceptional student understanding and comprehension of pathophysiology. An expanded, robust and flexible suite of supplements makes it easy for you to select the best course resources, so you can meet your students' changing needs. For both discrete and hybrid courses, the flexibility and power of Porth allows you to customize the amount of pathophysiology that you need for effective teaching and learning. Including a resource DVD with text!

The 5-Minute Clinical Conult 2014 Standard Edition provides rapid-access in a quick-reference format. It delivers diagnosis, treatment, medications, follow-up, and associated factors for a broad range of diseases and conditions. Organized alphabetically by diagnosis, this best-selling clinical reference continues to present brief, bulleted information on disease topics in a consistent and reader-friendly three-column format.

This forum of comprehensive reviews and research studies on distinct aspects of the pathophysiology of BAV aortopathy provides both the state of the art in the knowledge on this complex disease and novel insights into its causes and consequences. The present collection of focused papers also envisions and proposes new therapeutic strategies, novel biomarkers and original risk stratification criteria, for the improvement of patient management.

This book covers the latest research development in heart valve biomechanics and bioengineering, with an emphasis on novel experimentation, computational simulation, and applications in heart valve bioengineering. The most current research accomplishments are covered in detail, including novel concepts in valvular viscoelasticity, fibril/molecular mechanisms of tissue behavior, fibril kinematics-based constitutive models, mechano-interaction of valvular interstitial and endothelial cells, biomechanical behavior of acellular valves and tissue engineered valves, novel bioreactor designs, biomechanics of transcatheter valves, and 3D heart valve printing. This is an ideal book for biomedical engineers, biomechanics, surgeons, clinicians, business managers in the biomedical industry, graduate and undergraduate students studying biomedical engineering, and medical students.