The new and updated edition of this book explains the key steps in planning and executing diagnostic test accuracy studies in dementia, serving as an introduction to the topic with clear explanations of difficulties and pitfalls. It has been fully revised in light of developments over the past 5 years and includes STARD publications which have appeared since the first edition as well as the use of biomarkers of cognitive disorders as increasingly enshrined in diagnostic criteria. The book covers the presentation of study results in terms of measures of discrimination, taking examples from studies in dementia looking at various diagnostic methods including cognitive instruments, neuroimaging, and biochemical studies. The book continues to reflect the author’s own experience in diagnostic test accuracy studies, particularly in the sphere of cognitive screening instruments.. Diagnostic Test Accuracy Studies in Dementia encourages clinicians to adopt a pragmatic approach to diagnostic test accuracy studies rooted in day-to-day clinical practice.

This expanded, updated third edition summarizes the pragmatic diagnostic accuracy studies of neurological signs and cognitive and non-cognitive screening instruments undertaken in the author’s clinic in the context of day-to-day practice involving patients with cognitive disorders including dementia. A new chapter devoted to comparing and combining instruments is included, and illustrative case studies have been included where relevant. Dementia in Clinical Practice: A Neurological Perspective, Third Edition is a practical resource for medical professionals involved in the assessment and management of patients with dementia and cognitive disorders. It may be of particular interest to neurologists, psychiatrists, geriatricians, primary care practitioners and those working with patients with cognitive impairment in the fields of neuropsychology, psychology, occupational therapy, speech and language therapy and nursing.

In this special issue of Diagnostics, expert contributors have produced up-to-date research studies and reviews on various topics related to the diagnosis of dementia and cognitive impairment. The methods of the assessments discussed extend from simple neurological signs, which may be elicited in the clinical encounter, through cognitive screening instruments, to sophisticated analyses of neuroimaging and cerebrospinal fluid biomarkers of disease. It is hoped that these various methods may facilitate earlier diagnosis of dementia and its subtypes, and provide differential diagnosis of depression and functional cognitive disorders, as a prelude to meaningful interventions.

This book presents and discusses the numerous measures of test performance that can be derived from 2x2 tables. Worked examples based on pragmatic test accuracy study data are used in chapters to illustrate relevance to day-to-day clinical practice. Readers will gain a good understanding of sensitivity and specificity and predictive values along with many other parameters. The contents are highly structured and the use of worked examples facilitates understanding and interpretation. This book is a resource for clinicians in any discipline who are involved in the performance or assessment of test accuracy studies, and professionals in the disciplines of machine learning or informatics wishing to gain insight into clinical applications of 2x2 tables.

This revised and updated second edition provides a practical and structured overview of some of the most commonly used and easily available cognitive screening instruments applicable in the outpatient clinic and bedside setting. It now includes additional chapters on AD8 and also methodological aspects of systematic cognitive screening instrument assessment from the Cochrane Dementia and Cognitive Improvement Group. Expert authors from around the world equip the reader with clear instructions on the usage of each screening instrument, its strengths and weaknesses, and the time required for administration. Rules on scoring are also provided, such as how to correct for variations in the patient’s age or education, and suggested cut-off scores. Cognitive Screening Instruments: A Practical Approach, Second Edition is aimed at both clinicians and professionals in disciplines allied to medicine who are called upon to assess patients with possible cognitive disorders, including neurologists, old age psychiatrists, neuropsychologists, primary care physicians, dementia support workers, and members of memory assessment teams.

The new and updated edition of this book explains the key steps in planning and executing diagnostic test accuracy studies in dementia, serving as an introduction to the topic with clear explanations of difficulties and pitfalls. It has been fully revised in light of developments over the past 5 years and includes STARD publications which have appeared since the first edition as well as the use of biomarkers of cognitive disorders as increasingly enshrined in diagnostic criteria. The book covers the presentation of study results in terms of measures of discrimination, taking examples from studies in dementia looking at various diagnostic methods including cognitive instruments, neuroimaging, and biochemical studies. The book continues to reflect the author's own experience in diagnostic test accuracy studies, particularly in the sphere of cognitive screening instruments. Diagnostic Test Accuracy Studies in Dementia encourages clinicians to adopt a pragmatic approach to diagnostic test accuracy studies rooted in day-to-day clinical practice.

Presenting a practical text for the clinician on diagnosing various neurologic disorders and clinical presentations with an emphasis on the use of diagnostic testing. Detailed disorder-oriented chapters provide a brief summary of the clinical aspects, the differential diagnosis and comprehensive literature reviews of diagnostic testing for the disorder. Also features summaries of the contributors' experience with algorithms and/or their practical recommendations. Offers clear, practical guidance regarding indications, sensitivity and relative utility of neurologic testing in general practice.

The Second Edition of this highly acclaimed volume examines every major aspect of Alzheimer disease -- clinical, epidemiologic, structural, chemical, genetic, molecular, and therapeutic. This edition includes expanded coverage of the cellular-level exploration of related dementing disorders, with in-depth presentation of prion diseases, Pick's disease, fronto-temporal disorders, transgenic models, and biochemistry of presenilins. Treatment of symptoms with therapeutic drugs is discussed, along with outcomes of and problems inherent in clinical trials for AD. The broad coverage of AD in this book benefits clinicians, educators, investigators, and health administrators.