Although inflammation is one of the body's first responses to infection, overactive immune responses can cause chronic inflammatory diseases. Long-term low-grade inflammation has also been identified as a risk factor for other diseases. Diet, immunity and inflammation provides a comprehensive introduction to immunity and inflammation and the role that diet and nutrition play with regard to this key bodily response.Part one, an introductory section, discusses innate and adaptive immunity, mucosal immunity in a healthy gut and chronic inflammatory diseases and low grade inflammation. Chapters in part two highlight the role of micronutrients, including zinc, selenium, iron, vitamin A and vitamin D, in inflammation and immunity. Part three explores other dietary constituents and includes chapters on intestinal bacteria and probiotics, the impacts of prebiotics on the immune system and inflammation, and antimicrobial, immunomodulatory and anti-inflammatory effects of food bioactive proteins and peptides. Further chapters explore the role of olive oil, short and long chain fatty acids and arginine and glutamine in immune functions. Nutrition, immunity and inflammation are discussed from an integrative and life course perspective in part four. Chapters focus on adverse immune reactions to foods, early nutritional programming, the impact of nutrition on the immune system during ageing, the impact of exercise on immunity and the interaction with nutrition, and the effect that malnutrition has on immunity and susceptibility to infection.With its distinguished editors and international team of expert contributors, Diet, immunity and inflammation is a comprehensive resource for those researching immunology or inflammation, nutrition scientists, and professionals in the food and nutrition industries who require an understanding of the effect that diet can have on the immune system and inflammation. - Provides an overview of key research in the important and connected areas of inflammation, infection, overactive immune responses, diseases and diet - Outlines the fundamentals of immunity and inflammation and reviews the effects of different food constituents - Discusses important related issues, such as ageing and exercise

Gangliosides are negatively charged glycosphingolipids widely distributed in most vertebrate tissues and fluids. Human milk gangliosides might modulate physiological processes that take place in the early development of infants. This chapter describes the role of gangliosides as regulators of cell membrane organization and function, and in cell-cell recognition during normal differentiation or tissue targeting. As major components of membrane raft domains, dietary gangliosides may potentially influence a wide range of biological processes, including immune function, inflammation, neuronal signaling, entry of pathogens through the gut barrier and insulin resistance in metabolic disorders. Being involved in these processes, gangliosides may be critical for normal development and function, but they also might be involved in pathological processes.

Selenium (Se) is an essential micronutrient that is important for various aspects of human health, including optimal immune responses. This chapter summarizes evidence to date regarding the effects of dietary Se on allergies and asthma, aging immunity, clinical sepsis, immunity against various pathogens and other types of inflammation and immune responses. Also presented is information pertaining to mechanisms by which Se influences inflammation and immunity, including roles for individual selenoproteins.

The chapter begins by discussing the impact of intensive exercise training on immune function and susceptibility to infection in athletes. It then reviews the evidence that diet and nutritional supplements can modify immune responses to exercise and reduce infection incidence, symptom severity or duration in endurance athletes.

Immunity and Inflammation in Health and Disease: Emerging Roles of Nutraceuticals and Functional Foods in Immune Support provides a comprehensive description of the various pathways by which the vertebrate immune system works, the signals that trigger immune response and how fnew and novel nutraceuticals and functional foods, can be used to contain inflammation and also to boost immunity and immune health. Inflammation is a tool to fight pathogens and the vertebrate immune system has a very complex network of cells to achieve this. However inflammation that goes awry is also the leding cause of several diseases ranging from cardiovascular diseases to diabetes. This book covers the entire gamut from the various cellular players in the inflammation-immune response to its ramifications in terms of protection against pathogens as well as in onset of metabolic, aging and auto-immune related diseases. Finally, the balancing role of dietary nutrients between host defence and immune support is also showcased. The first three scetions explain the various components of the immune system and their modes of activation. The fourth section deals with the ramifications of a robust and execessive inflammatory response. The fifth section is focused on the association between nutrition and immunity and how deficiencies in certain nutrients may affect immunocompetence. The sixth section chapters represent a vision of paradigm shifts within the field and discusses possible future directions. This bool will be a valuable reference for researchers studying immune health either in academia, or in the nutraceutical or functional food industries. Product developers in nutraceutical, supplement, functional food, and health food companies will also appreciate the information presented here. - Conceptualizes the key features in natural products which can boost immune function and immune health - Explains the intricate mechanistic aspects and balance behind immune health - Presents the pathophysiology of several diseases associated with immune system disruption

Supporting initiation, development and resolution of appropriate immune responses is key to survival. Many nutrients and dietary components have been purported to have a role in supporting optimal immune function. This is vital throughout the life course, from the development and programming of the immune system in early life, to supporting immunity and reducing chronic inflammation in older people. In this special issue of Nutrients, we examine the evidence for the role of diet and dietary components in promoting protective immunity.

“Fascinating.…[Ravella’s writing] breathes life into biological functions.” —Grace Wade, New Scientist A riveting investigation of inflammation—the hidden force at the heart of modern disease—and how we can prevent, treat, or even reverse it. Inflammation is the body’s ancestral response to its greatest threats, the first line of defense it deploys against injury and foreign pathogens. But as the threats we face have evolved, new science is uncovering how inflammation may also turn against us, simmering underneath the surface of leading killers from heart disease and cancer to depression, aging, and mysterious autoimmune conditions. In A Silent Fire, gastroenterologist Shilpa Ravella investigates hidden inflammation’s emerging role as a common root of modern disease—and how we can control it. We meet the visionary nineteenth-century pathologist who laid the foundation for our modern understanding of inflammation, the eccentric Russian zoologist who discovered one of the cells central to our immune system, and the dedicated researchers advancing the frontiers of medical and nutritional science today. With fascinating case studies, Ravella reveals how we can reform our relationships with food and our microbiomes to benefit our own health and the planet’s. Synthesizing medical history, cutting-edge research, and innovative clinical practice, Ravella unveils inflammation as one potential basis for a unifying theory of disease. A paradigm-shifting understanding of one of the most mysterious, buzzed-about topics in medicine and nutrition, A Silent Fire shows us how to live not only long but well.

Inflammation and Immunity in Depression: Basic Science and Clinical Applications is the first book to move beyond the established theory of cytokine-induced depression and explore the broader role the immune system plays in this devastating mood disorder. The book fully explores the most recent lines of research into this rapidly advancing field, including alterations of T-cells, the neurobiological implications of neuroinflammation and immune alterations for brain development and function, and the genetic components of neuroinflammation in depression, including the relationships between stress and inflammation that are revealing gene-environment interactions in the disorder. Combining contributions from researchers worldwide, this book provides the most comprehensive discussion available today on the involvement of the innate immune and adaptive immune systems in depressive disorder. Chapters span neuroscience, psychology, clinical applications and future directions, making this book an invaluable resource for advanced students, researchers and practitioners who need to understand the complex and varied role of inflammation and immune responses in depression. - Synthesizes current knowledge of inflammation and immunity in depression, ranging from basic neuroscience research, to clinical applications in psychiatry - Expands on the long-established theory of cytokine-induced depression to discuss broader involvement of the immune system - Explores translational potential of targeting immune dysfunction for clinical interventions

A 10-week meal and exercise plan aimed at helping you lose weight and keep it off in the healthiest way possible, from Australia’s favourite clinical nutritionist Sarah Di Lorenzo. Want to lose weight and keep it off forever? Clinical nutritionist Sarah Di Lorenzo shows you how in this easy-to-follow program. Drawing from her own experiences, Sarah explains the factors that contribute to weight gain – stress, lack of sleep, unhealthy food options, mental and societal roadblocks – and provides tips on how to eliminate or respond more effectively to overcome the obstacles standing in the way of weight loss. Rejecting the notion of fad diets, Sarah has crafted a manageable, achievable program aimed at people with busy lifestyles. Now with a bonus chapter on how to fit the 10:10 plan into your everyday life along with brand new recipes created by the 10:10 community, The 10:10 Plan will have you feeling healthier than ever. ‘I want you to know that with Sarah’s help, you WILL reach your goal weight. But more than that – you WILL keep it off. Plus, your mind WILL be clear, and you WILL have energy in abundance. Put simply, you WILL feel amazing.’ Monique Wright, journalist and TV presenter 'Over the years I’ve bought every health-kick book there is … Now, thanks to Sarah, I’ve finally found what works for me! Her detox approach is a celebration of food and feeling your best. No punishment, restriction or radical plans. Instead, a clear roadmap to restoring your best health, based on actual science … The most surprising result – I’m still following its principles long after my 10 weeks are done. The other books are binned; Sarah’s plan has become a way of life.' Sally Bowrey, journalist and TV presenter ‘Sarah showed me how to do something I hadn’t been able to do in years … lose those last, stubborn few kilos that annoyed and frustrated me. She gave me a healthy plan to stick to, with no tiresome calories counting, just good food.’ Natalie Barr, journalist and TV presenter.

Inflammatory Diseases of Blood Vessels“/b> Inflammatory Diseases of Blood Vessels Second Edition Inflammatory Diseases of Blood Vessels provides a comprehensive overview of the science and clinical consequences of vascular inflammation in health and disease. In recent years, considerable progress has been made in understanding different forms of vasculitis. Investigation of pathogenesis of vascular inflammation has led to improved treatments and outcomes. Surgical and transplant procedures have improved in parallel with medical therapies. These areas are extensively examined in this new edition. Inflammatory Diseases of Blood Vessels is an excellent resource for a broad readership, including clinicians, investigators and their support teams in numerous specialties e.g. rheumatology, immunology, cardiology, cardiovascular surgery, pulmonary medicine, nephrology, pathology, vascular biology, embryology and imaging.