Applications of nucleic acids have developed recently to provide solutions for biosensors, diagnostic tools and as platforms for the assembly of complex structures. These developments have been possible as their base sequence can be used to assemble precise structures following simple and predictable rules. Self-assembled DNA can then be amplified using polymerase chain reaction (PCR) and this ultimately enables the preparation of synthetic nucleic acids. Their use as molecular tools or DNA-conjugates has recently been enhanced by the addition of other groups including enzymes, fluorophores and small molecules. Written by leaders in the field, this volume describes the preparation and application of these DNA-conjugates. Several have been used as sensors (aptamers, riboswitches and nanostructures) based on the ability of nucleic acids to adopt specific structures in the presence of ligands, whilst others link reporter groups such as proteins or fluorophores to RNA or DNA for detection, single molecule studies, and increasing the sensitivity of PCR. The book is relevant to researchers in areas related to analytical chemistry, chemical biology, medicinal chemistry, molecular pharmacology, and structural and molecular biology.

Biological DNA Sensor defines the meaning of DNA sensing pathways and demonstrates the importance of the innate immune responses induced by double stranded DNA (dsDNA) through its influencing functions in disease pathology and immune activity of adjuvants for vaccines. Though discussed in specific subsections of existing books, dsDNA and its immunogenic properties has never received the complete treatment given in this book. Biological DNA Sensor approaches the impact of dsDNA's immunogenicity on disease and vaccinology holistically. It paints a complete and concise picture on the topic so you can understand this area of study and make more informed choices for your respective research needs. Chapters are authored by researchers who are renowned for their research focus, ensuring that this book provides the most complete views on the topics. - Multi-authored by a distinguished panel of world-class experts - Ideal source of information for those wanting to learn about DNA sensing - Provides in-depth explanations of DNA sensing pathways and the innate immune system, bridging the gap between them

This book offers an overview of state-of-the-art in non amplified DNA detection methods and provides chemists, biochemists, biotechnologists and material scientists with an introduction to these methods. In fact all these fields have dedicated resources to the problem of nucleic acid detection, each contributing with their own specific methods and concepts. This book will explain the basic principles of the different non amplified DNA detection methods available, highlighting their respective advantages and limitations. Non-amplified DNA detection can be achieved by adopting different techniques. Such techniques have allowed the commercialization of innovative platforms for DNA detection that are expected to break into the DNA diagnostics market. The enhanced sensitivity required for the detection of non amplified genomic DNA has prompted new strategies that can achieve ultrasensitivity by combining specific materials with specific detection tools. Advanced materials play multiple roles in ultrasensitive detection. Optical and electrochemical detection tools are among the most widely investigated to analyze non amplified nucleic acids. Biosensors based on piezoelectric crystal have been also used to detect unamplified genomic DNA. The main scientific topics related to DNA diagnostics are discussed by an outstanding set of authors with proven experience in this field.

Electrochemical Sensors: From Working Electrodes to Functionalization and Miniaturized Devices provides an overview of the materials, preparation and fabrication methods for biosensor applications. The book introduces the field of electrochemistry and its fundamentals, also providing a practical overview of working electrodes as key components for the implementation of sensors and assays. Features covered include the prompt transfer of electrons, favorable redox behavior, biocompatibility, and inertness in terms of electrode fouling. Special attention is dedicated to analyzing the various working materials systems for electrodes used in electrochemical cells such as gold, carbon, copper, platinum and metal oxides. This book is suitable for academics and practitioners working in the disciplines of materials science and engineering, analytical chemistry and biomedical engineering. - Introduces key concepts for electrochemistry and biosensors - Reviews the most common and emerging materials-based electrodes for sensor applications, including gold, carbon, platinum and metal oxides - Discusses both macro and miniaturized electrodes, including their cleaning, engineering, fabrication, examples of working biosensors, and advantages and disadvantages

PHOTONIC SENSING A cutting-edge look at safety and security applications of photonic sensors With its many superior qualities, photonic sensing technology is increasingly used in early-detection and early-warning systems for biological hazards, structural flaws, and security threats. Photonic Sensing provides for the first time a comprehensive review of this exciting and rapidly evolving field, focusing on the development of cutting-edge applications in diverse areas of safety and security, from biodetection to biometrics. The book brings together contributions from leading experts in the field, fostering effective solutions for the development of specialized materials, novel optical devices, and networking algorithms and platforms. A number of specific areas of safety and security monitoring are covered, including background information, operation principles, analytical techniques, and applications. Topics include: Document security and structural integrity monitoring, as well as the detection of food pathogens and bacteria Surface plasmon sensors, micro-based cytometry, optofluidic techniques, and optical coherence tomography Optic fiber sensors for explosive detection and photonic liquid crystal fiber sensors for security monitoring Photonics-assisted frequency measurement with promising electronic warfare applications An invaluable, multidisciplinary resource for researchers and professionals in photonic sensing, as well as safety and security monitoring, this book will help readers jump-start their own research and development in areas of physics, chemistry, biology, medicine, mechanics, electronics, and defense.

This Special Issue focuses on all aspects of the recent research and development related to fiber optic sensors. The recent advances in fiber-based sensing technologies have enabled both fundamental studies and a wide spectrum of applications. The goal of this Special Issue is to bring attention to the most recent results in the field of fiber optic sensors, including new mechanisms, materials, processes, and applications.

The text covers fiber optic sensors for biosensing and photo-detection, graphene and CNT-based sensors for glucose, cholesterol, and dopamine detection, and implantable sensors for detecting physiological, bio-electrical, biochemical, and metabolic changes in a comprehensive manner. It further presents a chapter on sensors for military and aerospace applications. It will be useful for senior undergraduate, graduate students, and academic researchers in the fields of electrical engineering, electronics, and communication engineering. The book Discusses implantable sensors for detecting physiological, bio-electrical, biochemical, and metabolic changes Covers applications of sensors in diverse fields including healthcare, industrial flow, consumer electronics, and military Includes experimental studies such as the detection of biomolecules using SPR sensors and electrochemical sensors for biomolecule detection Presents artificial neural networks (ANN) based industrial flow sensor modeling Highlights case studies on surface plasmon resonance sensors, MEMS-based fluidic sensors, and MEMS-based electrochemical gas sensors The text presents case studies on surface plasmon resonance sensors, MEMS-based fluidic sensors, and MEMS-based electrochemical gas sensors in a single volume. The text will be useful for senior undergraduate, graduate students, and academic researchers in the fields of electrical engineering, electronics, and communication engineering.

Despite achievements in the application of enzymes, antibodies and biological receptors to diagnostics and sensing, the last two decades have also witnessed the emergence of a number of alternative technologies based on synthetic chemistry. This volume shows how synthetic receptors can be designed with characteristics that make them attractive alternatives to biological molecules in the sensory and diagnostics fields, with contributions from leading experts in the area. Subjects covered include synthetic receptors for a range of biomolecules, the use of antimicrobial peptides for the detection of pathogenic microorganisms, the development of molecularly imprinted polymer (MIP) nanoparticles, the in silico design of MIPs and MIP-based sensors, and two chapters examining the development of sensors from an industrial point of view. The particular focus of all chapters is on practical aspects, either in the development process or the applications of the synthesized materials. This book will serve as an important reference work for business leaders and technology experts in the sensors and diagnostics sector.

Fundamentals of Sensor Technology: Principles and Novel Designs presents an important reference on the materials, platforms, characterization and fabrication methods used in the development of chemical sensor technologies. Sections provide the historical context of sensor technology development, review principles for the design of sensing devices and circuits, delve into the most common chemical and biological sensor types, cover unique properties and performance requirements, discuss fabrication techniques, including defining critical parameters, modeling and simulation strategies, and present important materials categories used in sensing applications, such as nanomaterials, quantum dots, magnetic materials, and more.This book is appropriate for the interdisciplinary community of researchers and practitioners interested in the development of sensor technologies, including materials scientists and engineers, analytical chemists and other related disciplines. - Provides a comprehensive view of the latest advances in the design of chemical sensor materials, devices, and platforms - Reviews the most relevant nanosensor fabrication techniques for each sensor type, including critical parameters, modeling, simulation strategies and characterization methods - Discusses enhancement strategies for materials and devices to help improve physical, chemical and biological properties and enable practical applications