Morbus Dupuytren is particularly widespread among northern Europeans. However, the therapeutic success-rate often leaves much to be desired. A 50% recurrence-rate after surgery indicates that the disease cannot be treated by surgery alone. This book therefore adopts two parallel approaches: emphasis is firstly placed on the systemic character of morbus Dupuytren in context with other connective tissue diseases by a description of the biochemical and molecular-biological changes in the diseased connective tissues; secondly, a diversified picture of the given anatomical facts serves to explain the employment of the various therapeutic approaches. Further, a description is given of the current surgical procedures.

This book is based on results of the 2010 International Symposium on Dupuytren's disease held in Miami, Florida, but it also includes new data and additional chapters. It is hoped that it will raise awareness of this underestimated condition and promote cooperative efforts to work towards a cure. Up to date information is provided on the epidemiology, biology, and pathology of the disease. The principles and specifics of treatment are explored in detail. The indications for and techniques of radiotherapy, minimally invasive treatments and open surgery are fully explained. The role of physical therapy is considered as well as the care of relapse and complications. The treatment of Ledderhose’s disease and Peyronie’s disease is also discussed. This book provides invaluable information for hand surgeons, podiatrists, orthopedists, radiation therapy specialists and general practitioners. It will help to foster an interdisciplinary approach to the understanding and management of this debilitating disorder.

Dupuytren's Disease: A Scientific Review offers consolidated, up-to-date coverage of both the basic normal (nonpathologic) science and cutting-edge science of this progressive disorder. Drs. Lawrence C. Hurst, Marie A. Badalamente, and David Edward Komatsu break down the complex topic of Dupuytren's contracture into its basic scientific components. Hand surgeons, plastic surgeons, and orthopaedic surgeons will find this unique, concise title to be especially helpful in their practices. - Includes chapters on prevalence of Dupuytren's disease, normal genetics and the genetic abnormalities associated with Dupuytren's disease, and collagen and collagen synthesis in healthy fascia and Dupuytren's disease. - Provides numerous illustrations throughout. - Contains an in-depth bibliography and a useful, complete glossary of related terms. - Consolidates today's available information on Dupuytren's science into a single, convenient resource.

In this volume a distinguished group of internationally renowned clinicians and basic researchers discuss the present state of knowledge of the etiologyand pathogenesis of Dupuytren's contracture, a disease responsible for a considerable portion of disabilities within the working population allover the world. Although the riddle of how the contracture of the palmar fascia develops is still unsolved, the data on the pathobiochemistry and clinic of Dupuytren's Disease achieved in recent years has led to a better understanding of the biochemical and morphological processes underlying the deformation and malfunction of the afflicted tissues. Research in Dupuytren's Disease now enters the era of molecular medicine, which opens up new experimental means of studying the pathological changes which occur during the formation of the contracture on a molecular level. In particular, data are presented as to the role of specific biological macromolecules influencing the phenotype expression of the palmar fascia cells which are involved in autoimmune reactions and present both at the cell surface as well as in the extracellular matrix to regulate cell-to-cell and cell-to-matrix interactions. In vitro cell culture models to investigate fibro-cytic modulations are available and havebeen applied to study the effects of specific biological molecules on isolated cells from healthy palmar fascia and Dupuytren's contracture. Complementary evaluations of morphological, epidemiological, and clinical data contribute essentially to the present understanding of the etiology and pathogenesis of Dupuytren's Disease. This comprehensive and informative summary of the state of the art is completed by numerous references affixed to the individual contributions.

In this book, leading international experts showcase the latest advances in research into Dupuytren disease and its clinical management. The coverage spans all relevant specialties, including cell biology, biomechanics, genomics, surgery, pharmacotherapy, and radiotherapy. The opening sections address epidemiology, cellular and extracellular events, and genetics. Treatment by means of collagenase injection, percutaneous needle fasciotomy, and other surgical and minimally invasive approaches is then extensively discussed. Comparative studies of different approaches are reviewed, and aspects of patient assessment, examined. The prevention and treatment of disease recurrences are also addressed. Further sections consider related conditions, other treatment options, and future pathways for research. This book should be read by all who treat or conduct research into Dupuytren disease. It is based on presentations delivered at the 2015 International Conference on Dupuytren Disease, held in Groningen, the Netherlands, which was designed to promote a coordinated global response to the disease involving patients, scientists, and clinicians.

This issue of Hand Clinics, guest edited by Dr. Steve Haase, as well as the series’ consulting editor Dr. Kevin Chung, will cover a number of key aspects of Dupuytren Disease. Topics discussed within the issue include, but are not limited to: Risk Factors, Disease Associations, and Dupuytren Diathesis, Pathologic Anatomy in Dupuytren Disease, Needle Aponeurotomy for Dupuytren Disease, Development of Collagenase Treatment for Dupuytren Disease, Collagenase Injection for Dupuytren Disease, Alternative and Adjunctive Treatments for Dupuytren Disease, Comparative Outcomes of Dupuytren Disease Treatment, Complications of Dupuytren Disease Treatment, The Role of Hand Therapy in Dupuytren Disease, Treatment of Recurrent Dupuytren Disease, and Advances in Minimally Invasive Treatment of Dupuytren Disease.

This book offers detailed guidance on the use of collagenase, or enzymatic fasciotomy, as a nonsurgical treatment for Dupuytren’s contracture and explains its role in relation to the other forms of treatment, including open fasciectomy, needle aponeurotomy, and lipofilling. Clear guidance is provided on technique, current indications, and off-label usage. With the help of tips and tricks from leading experts, the reader will learn how to personalize the procedure to meet the needs of individual patients. Advice is also provided on all aspects of rehabilitation, which is a key determinant of treatment outcome. Collagenase treatment of Dupuytren’s disease has the benefits of low invasiveness and rapid patient recovery and achieves reasonable recurrence-free periods. It is especially valuable in patients with rapid recurrence following surgery. In documenting and appraising every aspect of its use, this book will be of value for all who treat patients with Dupuytren’s disease, including hand surgeons, orthopedists, plastic surgeons, physiatrists, and physiotherapists.

This volume discusses the background and various clinical applications of radiation therapy in the treatment of non-malignant diseases. It documents the radiobiological and physical principles of treatment and the rationale underlying the use of radiotherapy for various disorders of the CNS, head and neck, eye, skin and soft tissues, bone and joints, and vascular system. In so doing, it draws attention to and elucidates the scope for application of radiotherapy beyond the treatment of malignancies. Both the risks and the benefits of such treatment are fully considered, the former ranging from minor clinical problems to life-threatening diseases.

Unrivalled in scope and depth, Campbell’s Operative Orthopaedics continues to be the most widely used resource in orthopaedic surgery, relied on for years by surgeons across the globe. It provides trusted guidance on when and how to perform every state-of-the-art procedure that's worth using, with updates to the new edition including hundreds of new techniques, illustrations, and digital diagnostic images to keep you abreast of the latest innovations. Each chapter follows a standard template, with highlighted procedural steps that lead with art and are followed by bulleted text. Covers multiple procedures for all body regions. In-depth coverage helps you accommodate the increasing need for high-quality orthopaedic care in our aging population. Achieve optimal outcomes with step-by-step guidance on today's full range of procedures, brought to you by Drs. Canale, Beaty, and Azar, and many other contributors from the world-renowned Campbell Clinic. Expanded online library boasts high-quality videos of key procedures. Includes approximately 100 new techniques, 300 new illustrations, and 500 new or updated photos and high-quality digital diagnostic images. Features evidence-based surgical coverage wherever possible to aid in making informed clinical choices for each patient. Highlights the latest knowledge on total joint arthroplasty in the ambulatory surgery center, including how to manage metal sensitivity. Provides up-to-date details on rib-based distraction implants (VEPTR) and remote-controlled growing rods (MAGEC) for scoliosis; diagnosis of femoroacetabular impingement (FAI) and its influence on development of osteoarthritis; and the treatment of FAI with the mini-open direct anterior approach. Extensive art program is consistent throughout the 4 volumes, providing a fresh, modern look. Expert Consult eBook version included with purchase. This enhanced eBook experience allows you to search all of the text, figures, images, videos, and references from the book on a variety of devices.

Winner of the 2011 BMA book awards: medicine categoryIn the five decades since its first publication, Hunter's Diseases of Occupations has remained the pre-eminent text on diseases caused by work, universally recognized as the most authoritative source of information in the field. It is an important guide for doctors in all disciplines who may