Discusses how to fight Ebola, SARS Corona, and other known or emerging human viruses by building on the successes in antiviral therapy of the past decades Written by leading medicinal chemists from academia and industry, this book discusses the entire field of antiviral drug discovery and development from a medicinal chemistry perspective, focusing on antiviral drugs, targets, and viral disease mechanisms. It provides an outlook on emerging pathogens such as Ebola, Zika, West Nile, Lassa, and includes a chapter on SARS Coronoavirus-2 causing the present pandemic. New Drug Development for Known and Emerging Viruses describes the discovery and development process for antiviral agents for different classes of viruses and targets based on the experiences from the nine human viruses for which approved drugs are on the market (HIV, HCV, Influenza, RSV, HBV, HPV, HCMV, HSV, and VZV). It covers the properties and potential of 20 classes of currently approved antivirals, including combination drugs, and looks at novel antiviral strategies against emerging viruses. Covers the entire field of antiviral drug discovery and development Addresses the need for antiviral drugs to combat major health threats such as Ebola, Zika, West Nile, and SARS Coronavirus-2 Summarizes the successes of the past 15 years in developing ground-breaking medicines against 9 major human viruses, both from the medicinal chemistry and the pharmacological angle Discusses practical and strategic challenges in the drug discovery and development process, including screening technologies, latency, and toxicity issues New Developments in Antiviral Drugs is an important book for medicinal chemists, pharmaceutical chemists, virologists, and epidemiologists, and will be of great interest to those in the pharmaceutical industry and public health agencies.

Emerging and Reemerging Viral Pathogens: Fundamental and Basic Virology Aspects of Human, Animal and Plant Pathogens, Volume One presents new research information on viruses and their impact on the scientific community. It provides a reference book on certain viruses in humans, animals and vegetal, along with a comprehensive discussion on interspecies interactions. The book then looks at the drug, vaccine and bioinformatical strategies that can be used against these viruses, giving the reader a clear understanding of transmission. The book's end goal is to create awareness that the appearance of newly transmissible pathogens is a global risk that requires shared/adoptable policies for prevention and control. - Covers most emerging viral disease in humans, animals and plants - Provides the most advanced tools and techniques in molecular virology and the modeling of viruses - Creates awareness that the appearance of new transmissible pathogens is a global risk - Highlights the need to adopt shared policies for the prevention and control of infectious diseases

Advances in Virus Research, Volume 120, the latest release in this esteemed series, presents the latest research and developments in viruses. - Provides the authority and expertise of leading contributors from an international board of authors - Presents the latest release in Advances in Virus Research series

Arboviruses have become global threats. Common to Dengue, Zika, yellow fever, chikungunya, and Mayaro viruses is their ability to be transmitted by mosquitoes. Several strategies based on transgenics or microbiology are currently being field-tested. While this approach seems hopeful, the research community needs to focus on potential backlash from these technologies to prevent failure. The aim of the Special Issue is to cover different transmission routes that are untargeted by the newly developed strategies to foresee limitations. Here, Fontenille & Powell gave their insights on how a mosquito species becomes a global vector, Yen & Failloux presented the limitations of Wolbachia-based population replacement, Pereira-dos-Santos et al. reviewed the evidence that Aedes albopictus is an important vector, and Diagne et al. gathered information about the latest emerging arbovirus: Mayaro. Manuel et al. demonstrated that in certain conditions mosquitoes efficiently transmit Zika viruses and Rozo-Lopez et al. showed that midges vertically transmit stomatitis virus, highlighting the epidemiological significance of vertical transmission. Vector competence for secondary vectors was improved by Kosoltanapiwat et al. during entomological surveillance and by Fernandes et al. when evaluating different vector species competence for Zika viruses. Morales-Vargas et al. and Calvez et al. improved our understanding of DENV2 and DENV4 epidemiology.

The emergence of HIV disease and AIDS, the reemergence of tuberculosis, and the increased opportunity for disease spread through international travel demonstrate the critical importance of global vigilance for infectious diseases. This volume highlights risk factors for the emergence of microbial threats to health, warns against complacency in public health, and promotes early prevention as a cost-effective and crucial strategy for maintaining public health in the United States and worldwide. The volume identifies infectious disease threats posed by bacteria and viruses, as well as protozoans, helminths, and fungi. Rich in information, it includes a historical perspective on infectious disease, with focuses on Lyme disease, peptic ulcer, malaria, dengue, and recent increases in tuberculosis. The panel discusses how "new" diseases arise and how "old" ones resurge and considers the roles of human demographics and behavior, technology and industry, economic development and land use, international travel and commerce, microbial adaptation and change, and breakdown of public health measures in changing patterns of infectious disease. Also included are discussions and recommendations on disease surveillance; vaccine, drug, and pesticide development; vector control; public education and behavioral change; research and training; and strengthening of the U.S. public health system. This volume will be of immediate interest to scientists specializing in all areas of infectious diseases and microbiology, healthy policy specialists, public health officials, physicians, and medical faculty and students, as well as anyone interested in how their health can be threatened by infectious diseases.

The first volume of the book-Emerging Human Viral diseases presents pathogenesis, diagnostics, and therapeutic strategies against viral respiratory and hemorrhagic fever diseases. The initial chapter discusses the underlying factors contributing to the emergence of these viral diseases. The subsequent chapters introduce structure, composition, and organization of viral genomes, and provide insight into function of important viral proteins. It also discusses the host factors that influence the outcome of viral infection and host immune response to the infections caused by these viruses. The book also discusses clinical manifestation and strategies for the prevention of virus diseases and highlights the recent technical advances in the diagnosis of virus diseases, prevention, and control strategies for viral infections. This timely book offers valuable resource for the scientists working in the field of emerging viral infections and those involved in preventing, controlling, and managing viral diseases.