Professionals recognize entropy-enthalpy compensation as an important factor in molecular recognition, lead design, water networks, and protein engineering. It can be experimentally studied by proper combinations of diverse spectroscopic approaches with isothermal titration calorimetry and is clearly related to molecular dynamics. So, how should we treat entropy-enthalpy compensation? Is it a stubborn hindrance that solely complicates the predictability of phenomena otherwise laid on the line by Mother Nature? How should we then deal with it? This book dwells on these posers. It combines two chapters written by globally recognized specialists. Chapter 1 deals with general issues and suggests a definite approach to how we may answer the posers. Chapter 2 shows how the approach outlined might be successfully applied in a rational design of enzymes. This might provide other interesting strategic perspectives in the general theoretical physical chemistry field.

Chromatography

Macromolecules in the body form noncovalent associations, such as DNA-protein or protein-protein complexes, that control and regulate numerous cellular functions. Understanding how changes in the concentration and conformation of these macromolecules can trigger physiological responses is essential for researchers developing drug therapies to treat

This comprehensive monograph consists of two parts: Volume I, entitled Enzyme Catalysis, Kinetics, and Substrate Binding; and Volume II, entitled Mechanism of Enzyme Action. Volume I focuses on several aspects of enzyme catalytic behavior, their steady-state and transient-state kinetics, and the thermodynamic properties of substrate binding. Packed with figures, tables, schemes, and photographs, this volume contains over 1,000 references, including references regarding enzymology's fascinating history. This comprehensive book is of particular interest to enzymology students, teachers, and researchers. Volume II presents selected "cutting edge" examples of techniques and approaches being pursued in biochemistry. This up-to-date resource includes 11 chapters, which illustrate important theoretical and practical aspects of enzyme mechanisms. It also features selected examples in which today's most important techniques, ideas, and theories are used to elaborate on the intricate nature of enzyme action mechanisms. This particular volume provides important information for both the novice and the seasoned investigator.

This new book provides comprehensive coverage of the subjects of deuterium oxide and deuteration in biosciences, with an emphasis on the biochemical, biomedical, and pharmacological aspects. Deuterium oxide and deuteration effects also offer various implications for health-related issues, including diseases, vaccines and drugs. Organized in six sections, the chapter topics include the role of regular and heavy water in biosciences, and their implications to biomolecules, biochemical processes, health-related research, and pharmacology. Due to the broad scope, the book may be used as a supplemental text for upper-level undergraduate and graduate courses in the related fields of biochemistry, biology, biomedical sciences, biophysics, and pharmacology. Researchers and pharmaceutical industry professionals will also find the content useful in order to gain knowledge and better understand the implications of deuterium oxide and deuteration research.

The molecular modeling perspective in drug design. (N. Calude Cohen). Molecular graphics and modeling: tools of the trade. (Roderick E. Hubbard). Molecular modeling of small molecules. (Tamara Gund). Computer assisted new lead design. (Akiko Itai, Miho Yamada Mizutani, Yoshihiko Nishibata, and Nubuo Tomioka). Experimental techniques and data banks. (John P. Priestle and C. Gregory Paris). Computer-assisted drug discovery. (Peter Gund, Gerald Maggiora, and James P. Snyder). Modeling drug-receptor interactions. (Konrad F. Koehler, Shashidhar N. Rao, and James P. Snyder). Glossary of terminology. (J. P. Tollenaere).

This book elucidates the peculiar phenomenon of entropy/enthalpy compensation that takes place in high performance liquid chromatography (HPLC) of polymers. Numerous publications, including some books, are devoted to molecular characterization of synthetic polymers, materials presently produced in large and steadily growing quantities, applying methods of HPLC. A knowledge of the molecular characteristics of polymers is indispensable, not only for their proper applications but also for their recycling and remediation. Polymer scientists generally focus on synthesis and potential applications of polymers while not giving due attention to an important central link, their comprehensive characterization in context of development of structure-property correlations. To fill this gap is one of the aims of the present book. The process of entropy/enthalpy compensation plays a decisive role in the advanced method of polymer characterization such as liquid chromatography at critical conditions, eluent gradient interaction chromatography, and temperature gradient interaction chromatography. All chemists working on any aspect of polymer science will find this book a valuable resource for the development of structure-property correlations.

Modern thermodynamics is a unique but still not a logically self-consistent field of knowledge. It has a proven universal applicability and significance but its actual potential is still latent. The development of the foundations of thermodynamics was in effect non-stop but absolutely no one has any idea about this. This book is the first of its kind that will motivate researchers to build up a logically consistent field of thermodynamics. It greatly appreciates the actual depth and potential of thermodynamics which might also be of interest to readers in history and philosophy of scientific research. The book presents the life stories of the protagonists in detail and allows readers to cast a look at the whole scene of the field by showcasing a significant number of their colleagues whose works have fittingly complemented their achievements. It also tries to trigger a detailed analysis of the reasons why the actual work in this extremely important field has in effect gone astray. It comprises five chapters and introduces three scientists in the first two chapters, which are specifically devoted to the Scandinavian achievements in macroscopic thermodynamics. These introductions are novel and call for a detailed reconsideration of the field. The third chapter acquaints the readers with their fourth colleague in Germany who was working on the proper link between the macroscopic thermodynamics, kinetics, and the atomistic representation of matter. The fourth chapter brings in their fifth colleague in the United States who could formally infer the famous formula S = k * ln(W), ingeniously guessed by Ludwig Boltzmann, and thus clarify the physical sense of the entropy notion. The last chapter summarizes the above-mentioned discourses.

In additionto covering thoroughly the core areas of physical organic chemistry -structure and mechanism - this book will escortthe practitioner of organic chemistry into a field that has been thoroughlyupdated.

Temperature affects everything. It influences all aspects of the physical environment and governs any process that involves a flow of energy, setting boundaries on what an organism can or cannot do. This novel textbook reveals the key principles behind the complex relationship between organisms and temperature, namely the science of thermal ecology. It starts by providing a rigorous framework for understanding the flow of energy in and out of the organism, before describing the influence of temperature on what organisms can do and how fast they can do it. With these fundamental principles covered, the bulk of the book explores thermal ecology itself, incorporating the important extra dimension of interactions with other organisms. An entire chapter is devoted to the crucially important subject of how organisms are responding to climate change. Indeed, the threat of rapid climatic change on a global scale is a stark reminder of the challenges that remain for evolutionary thermal biologists, and adds a sense of urgency to this book's mission.