The history of life is a nearly four billion year old story of transformative change. This change ranges from dramatic macroscopic innovations such as the evolution of wings or eyes, to a myriad of molecular changes that form the basis of macroscopic innovations. We are familiar with many examples of innovations (qualitatively new phenotypes that provide a critical benefit) but have no systematic understanding of the principles that allow organisms to innovate. This book proposes several such principles as the basis of a theory of innovation, integrating recent knowledge about complex molecular phenotypes with more traditional Darwinian thinking. Central to the book are genotype networks: vast sets of connected genotypes that exist in metabolism and regulatory circuitry, as well as in protein and RNA molecules. The theory can successfully unify innovations that occur at different levels of organization. It captures known features of biological innovation, including the fact that many innovations occur multiple times independently, and that they combine existing parts of a system to new purposes. It also argues that environmental change is important to create biological systems that are both complex and robust, and shows how such robustness can facilitate innovation. Beyond that, the theory can reconcile neutralism and selectionism, as well as explain the role of phenotypic plasticity, gene duplication, recombination, and cryptic variation in innovation. Finally, its principles can be applied to technological innovation, and thus open to human engineering endeavours the powerful principles that have allowed life's spectacular success.

Evolutionary innovations—the bony skeleton of vertebrates, avian flight, or the insect pollination system of angiosperms, for example—have in recent years become the focus of much fertile new research in evolutionary biology. Innovations may hold the keys to understanding why whole new groups of organisms evolve or, conversely, why groups of organisms become extinct. This volume brings together contributors from the fields of morphology, genetics, embryology, physiology, and paleontology to present research on evolutionary innovations and to suggest directions for further work. The topics covered include the plurality of evolutionary innovations, patterns and processes at different hierarchical levels, evolutionary genetics of adaptations, heterochrony and other mechanisms of radical evolutionary change in early development, developmental mechanisms at the origin of morphological novelty, the evolution of morphological variation patterns, functional design and its punctuated products, plausibility and testability in assessing the consequences of evolutionary innovations, paradigms and pitfalls of studying physiological evolution, polyphyletic constructional breakthroughs in fossil and extant species, ecology of evolutionary innovations in the fossil record.

A major synthesis of homology, written by a top researcher in the field Homology—a similar trait shared by different species and derived from common ancestry, such as a seal's fin and a bird’s wing—is one of the most fundamental yet challenging concepts in evolutionary biology. This groundbreaking book provides the first mechanistically based theory of what homology is and how it arises in evolution. Günter Wagner, one of the preeminent researchers in the field, argues that homology, or character identity, can be explained through the historical continuity of character identity networks—that is, the gene regulatory networks that enable differential gene expression. He shows how character identity is independent of the form and function of the character itself because the same network can activate different effector genes and thus control the development of different shapes, sizes, and qualities of the character. Demonstrating how this theoretical model can provide a foundation for understanding the evolutionary origin of novel characters, Wagner applies it to the origin and evolution of specific systems, such as cell types; skin, hair, and feathers; limbs and digits; and flowers. The first major synthesis of homology to be published in decades, Homology, Genes, and Evolutionary Innovation reveals how a mechanistically based theory can serve as a unifying concept for any branch of science concerned with the structure and development of organisms, and how it can help explain major transitions in evolution and broad patterns of biological diversity.

This is a study of the commercial development of biotechnology which compares the initiatives, activities and organization of two firms--Genetech in the United States and Kabi in Sweden--as they brought knowledge to the market in the form of insulin and the human growth hormone. Writing from a broad evolutionary perspective, Maureen McKelvey's important study of one of the most modern science-based technologies will be of interest to all concerned with understanding the processes of innovation.

The term globalization has gained widespread popularity; yet most treatments are either descriptive and/or focused on changes in economic interconnectivity. In this volume the concept is seen in broader terms as leading international experts from a range of disciplines develop a long-term analysis to address the problems of globalization. The editors and contributors develop a framework for understanding the origins and trajectory of contemporary world trends, constructing testable and verifiable models of globalization. They demonstrate how the evolutionary approach allows us to view globalization as an enterprise of the human species as a whole focusing on the analytical problem of global change and the rules governing those changes. The emphasis is not on broad-based accounts of the course of world affairs but, selectively, on processes that reshape the social of the human species, the making of world opinion and the innovations that animate these developments. Chapters are clustered into four foci. One emphasizes the interpretation of globalization as an explicitly evolutionary process. A second looks at historical sequences of such phenomena as population growth or imperial rise and decline as processes that can be modeled and not purely described. The third cluster examines ongoing changes in economic processes, especially information technology. A final cluster takes on some of the challenges associated with forecasting and simulating the complexities of globalization processes. This innovative and important volume will be of interest to students and scholars across the social sciences concerned with the phenomenon of globalization.

The book aims to introduce the reader to the emerging field of Evolutionary Systems Biology, which approaches classical systems biology questions within an evolutionary framework. An evolutionary approach might allow understanding the significance of observed diversity, uncover “evolutionary design principles” and extend predictions made in model organisms to others. In addition, evolutionary systems biology can generate new insights into the adaptive landscape by combining molecular systems biology models and evolutionary simulations. This insight can enable the development of more detailed mechanistic evolutionary hypotheses.

The Darwinian theory of evolution is itself evolving and this book presents the details of the core of modern Darwinism and its latest developmental directions. The authors present current scientific work addressing theoretical problems and challenges in four sections, beginning with the concepts of evolution theory, its processes of variation, heredity, selection, adaptation and function, and its patterns of character, species, descent and life. The second part of this book scrutinizes Darwinism in the philosophy of science and its usefulness in understanding ecosystems, whilst the third section deals with its application in disciplines beyond the biological sciences, including evolutionary psychology and evolutionary economics, Darwinian morality and phylolinguistics. The final section addresses anti-Darwinism, the creationist view and issues around teaching evolution in secondary schools. The reader learns how current experimental biology is opening important perspectives on the sources of variation, and thus of the very power of natural selection. This work examines numerous examples of the extension of the principle of natural selection and provides the opportunity to critically reflect on a rich theory, on the methodological rigour that presides in its extensions and exportations, and on the necessity to measure its advantages and also its limits. Scholars interested in modern Darwinism and scientific research, its concepts, research programs and controversies will find this book an excellent read, and those considering how Darwinism might evolve, how it can apply to the human sciences and other disciplines beyond its origins will find it particularly valuable. Originally produced in French (Les Mondes Darwiniens), the scope and usefulness of the book have led to the production of this English text, to reach a wider audience. This book is a milestone in the impressive penetration by Francophone scholars into the world of Darwinian science, its historiography and philosophy over the last two decades. Alex Rosenberg, R. Taylor Cole Professor of Philosophy, Duke University Until now this useful and comprehensive handbook has only been available to francophones. Thanks to this invaluable new translation, this collection of insightful and original essays can reach the global audience it deserves. Tim Lewens, University of Cambridge

Introducing a handbook for gene regulatory network research using evolutionary computation, with applications for computer scientists, computational and system biologists This book is a step-by-step guideline for research in gene regulatory networks (GRN) using evolutionary computation (EC). The book is organized into four parts that deliver materials in a way equally attractive for a reader with training in computation or biology. Each of these sections, authored by well-known researchers and experienced practitioners, provides the relevant materials for the interested readers. The first part of this book contains an introductory background to the field. The second part presents the EC approaches for analysis and reconstruction of GRN from gene expression data. The third part of this book covers the contemporary advancements in the automatic construction of gene regulatory and reaction networks and gives direction and guidelines for future research. Finally, the last part of this book focuses on applications of GRNs with EC in other fields, such as design, engineering and robotics. • Provides a reference for current and future research in gene regulatory networks (GRN) using evolutionary computation (EC) • Covers sub-domains of GRN research using EC, such as expression profile analysis, reverse engineering, GRN evolution, applications • Contains useful contents for courses in gene regulatory networks, systems biology, computational biology, and synthetic biology • Delivers state-of-the-art research in genetic algorithms, genetic programming, and swarm intelligence Evolutionary Computation in Gene Regulatory Network Research is a reference for researchers and professionals in computer science, systems biology, and bioinformatics, as well as upper undergraduate, graduate, and postgraduate students. Hitoshi Iba is a Professor in the Department of Information and Communication Engineering, Graduate School of Information Science and Technology, at the University of Tokyo, Toyko, Japan. He is an Associate Editor of the IEEE Transactions on Evolutionary Computation and the journal of Genetic Programming and Evolvable Machines. Nasimul Noman is a lecturer in the School of Electrical Engineering and Computer Science at the University of Newcastle, NSW, Australia. From 2002 to 2012 he was a faculty member at the University of Dhaka, Bangladesh. Noman is an Editor of the BioMed Research International journal. His research interests include computational biology, synthetic biology, and bioinformatics.

While dating from post-Classical economists such as Thorstein Veblen and Joseph Schumpeter, the inception of the modern field of evolutionary economics is usually dated to the early 1980s. Broadly speaking, evolutionary economics sees the economy as undergoing continual, evolutionary change. Evolutionary change indicates that these changes were not planned, but rather were the result of innovations and selection processes. These often involved winners and losers, but most importantly, they resulted in actors learning what was and was not working. Evolutionary economics, in contrast to mainstream economics, emphasises the relevance of variables such as technology, institutions, decision rules, routines, or consumer preferences for explaining the complex evolutionary changes in the economy. In so doing, evolutionary economics significantly broadens the scope of economic analysis, and sheds new light on key concepts and issues of the discipline. This handbook draws on a stellar cast list of international contributors, ranging from the founders of the field to the newest voices. The volume explores the current state of the art in the field of evolutionary economics at the levels of the micro (e.g. firms and households), meso (e.g. industries and institutions), and macro (e.g. economic policy, structure, and growth). Overall, the Routledge Handbook of Evolutionary Economics provides an excellent overview of current trends and issues in this rapidly developing field.

This volume presents the results of Bulgarian and international tourism research, and brings together selected papers from the international conference “Tourism and Innovations” held in Varna, Bulgaria, in 2018. It contains theoretical and empirical approaches towards various aspects of tourism concerning both innovations in tourism development and in foreign languages education. As a whole, the book presents innovative solutions and processes in tourism, including management and staff training, provoked by today’s opportunities and challenges for future tourism development. The first part is dedicated to issues in tourism innovation, ranging from those provoked from the changing global environment and tourism demand, through to social innovations concerning tourism products and human resources management. The second section of the book deals with traditions and innovations in foreign language education oriented to managers, operational staff and decision-makers in tourism.