This eBook is a collection of articles from a Frontiers Research Topic. Frontiers Research Topics are very popular trademarks of the Frontiers Journals Series: they are collections of at least ten articles, all centered on a particular subject. With their unique mix of varied contributions from Original Research to Review Articles, Frontiers Research Topics unify the most influential researchers, the latest key findings and historical advances in a hot research area! Find out more on how to host your own Frontiers Research Topic or contribute to one as an author by contacting the Frontiers Editorial Office: frontiersin.org/about/contact.

"This text is written explicitly for readers with an interest in the aging process and the effects that exercise has on the quality of life and various diseases and maladies of the aging population. It is expected that the readers using this book as a course textbook or as auxiliary reading for a course, will have taken at least an introductory course in human physiology. The text refers throughout to the three groups in the aging and health spectrum, average aging individuals, the frail elderly and Masters Athletes"--

In Aging, Physical Activity, and Health, Roy J. Shephard, one of the world's leading authorities on exercise science, reviews and synthesizes the scientific literature on the physiological changes of aging and how regular physical activity affects the aging process.Shephard's critical analysis features the latest theories on how aging and exercise affect such medical conditions as cardiorespiratory disease, musculoskeletal diseases, metabolic health, mental function, and general well-being. He provides conclusive physiological evidence that exercise is effective for reducing the risk of many diseases, maximizing independence, and improving the quality of life for the elderly. Shephard also discusses the economic and social consequences of an aging society.More than 1, 700 references make this book an excellent resource for those who want to investigate specific areas of aging and activity.

Human Aging: From Cellular Mechanisms to Therapeutic Strategies offers an exhaustive picture of all the biological aspects of human aging by describing the key mechanisms associated with human aging and covering events that could disrupt the normal course of aging. Each chapter includes a summary of the salient points covered, along with futures prospects. The book provides readers with the information they need to gain or deepen the skills needed to evaluate the mechanisms of aging and age-related diseases and to monitor the effectiveness of therapies aimed at slowing aging. The book encourages PhD and Postdoc students, researchers, health professionals and others interested in the biology of aging to explore the fascinating and challenging questions about why and how we age as well as what can and cannot be done about it. - Concentrates on different processes, e.g., oxidative stress, cellular senescence and Inflammaging - Offers the ability to access cross-sectional knowledge more easily - Written by expert researchers in biogerontology who are actively involved in various fields within aging research

Human spaceflight has required space agencies to study and develop exercise countermeasure (CM) strategies to manage the profound, multi-system adaptation of the human body to prolonged microgravity (μG). Future space exploration will present new challenges in terms of adaptation management that will require the attention of both exercise physiologists and operational experts. In the short to medium-term, all exploration missions will be realised using relatively small vehicles/habitats, with some exploration scenarios including surface operations in low (<1G) gravity conditions. The evolution of CM hardware has allowed modern-day astronauts to return to Earth with, on average, relatively moderate levels μG-induced adaptation of the musculoskeletal (MS) and cardiovascular (CV) systems. However, although the intense use of CM has attenuated many aspects of MS and CV adaptation, on an individual level, there remains wide variation in the magnitude of these changes. Innovations in CM programs have been largely engineering-driven, with new hardware providing capability for new modes of exercise and a wider range of exercise protocols, which, in turn, has facilitated the transfer of traditional, but effective, terrestrial concepts based around high frequency resistance (multiple-set, multiple repetition) and mediumintensity continuous aerobic training. As a result, International Space Station (ISS) CM specialists have focused their efforts in these domains, taking advantage of hardware innovations as and when they became available. However, terrestrial knowledge in human and exercise physiology has expanded rapidly during the lifetime of the ISS and, consequently, there is potential to optimize current approaches by re-examining terrestrial knowledge and identifying opportunities to implement this knowledge into operational practices. Current terrestrial knowledge in exercise physiology is the product of a large number of intervention studies in which the variables that contribute to the effects of physical activity (mode, frequency, duration, intensity, recovery) have been controlled and systematically manipulated. However, due to limited opportunities to perform intervention studies in both spaceflight analogues – head-down bed rest (HDBR) being considered the ‘gold standard’ – and spaceflight itself, it will not be possible to systematically investigate the contribution of these factors to the efficacy of in-flight CM. As such, it will be necessary to draw on terrestrial evidence to identify solutions/strategies that may be best suited to the constraints of exploration and prioritise specific solutions/strategies for evaluation in HDBR and in flight.

The effects of microgravity on the human organism have been studied for over 60 years. The experience of short- and long-term space flights revealed alterations in multiple physiological systems either in the course of the flight or afterward. Some of these changes represent serious risks for crew health and functional capacity. This fact served as the trigger for multiple countries with space program participants to develop spaceflight countermeasures and medical support systems. These activities are intended to counteract space flight effects such as axial and support unloading, muscle disuse, monotony, fluid redistribution, sensory deficit, etc. Some countermeasures have been adapted from Earth medicine and sports, while others have been created especially for space flights. Many of the observed space flight effects have similarities to conditions seen on Earth, such as: decrease of motor activity in aging people, immobilized patients, and professions associated with forced physical inactivity and isolation. Thus, many space countermeasures and medical support systems can be applied in Earth medicine and rehabilitation. For example, countermeasures like loading suits, lower body negative pressure suits, electromyostimulation of various regimens, water-salt supplements, vestibular training means, etc. have been used in Earth medicine and sports conditioning over the last 20 years.