An outstanding group of scientists have collaborated in the collection of case studies that comprise this major text-reference book. It examines in detail how genes operate in diverse living systems, including viruses, cells and more complex organisms; investigates how genotypes can be altered; and looks at the mapping and sequencing of human and other genomes. Students and professionals in biochemistry, molecular biology and genetics will enjoy this book.

In the present era various international organizations, such as FAO, UNO, IAEA, FNCA, etc., have unanimously agreed that millions of people in both developing and developed countries are not only facing a shortage of food, but also non-availability of nutrients. The main reason put forward by these agencies is that there is less genetic diversity prevalent in the major crops, which has been further diminished since the inception of conventional plant breeding. Since the first decade of the last century the mutation breeding approach has been pivotal in enhancing the genetic diversity of crops, thereby enriching the genetic pool. ‘Mutagenesis: exploring genetic diversity of crops’ describes the latest achievements in mutation breeding, with a particular focus on the development of novel mutant varieties and F1 hybrids of crops highly superior to the parental ones. The book details experimental as well as literary studies of induced mutagenesis and its role in developing the new potent varieties. The book will be useful for agricultural policy making authorities in countries of agricultural importance, scientific researchers, breeders, teachers and students keen to use mutation breeding and to explore its hidden potential to secure food and nutrient availability for the growing world population.

Delve into the intricate genetic ties between periodontitis and respiratory disease in this illuminating book. Synthesizing current research, it elucidates shared genetic risk factors and pathways, enriching our understanding of their complex interconnection. Providing insights for practitioners, it enables personalized treatment strategies, leveraging genetic insights for improved patient outcomes. Recognizing the evolving research landscape and challenges in unraveling gene-environment interactions, it underscores the necessity for targeted interventions and individualized therapies. With its comprehensive overview, this book empowers researchers and healthcare professionals, paving the way for advanced approaches to prevention, diagnosis, and treatment in this vital field.

Metabolic and endocrine disorders are the main burden of noncommunicable chronic diseases, and they serve as important risk factors for cardiovascular diseases or multiple cancers. To date, a large number of correlates have been identified, but few of them were modifiable and causal. In general, causal relationships can be conceptualized not only in a probabilistic sense involving statistical terms and procedures, but also in the complexity of biological phenomena. The limited understanding of many underlying mechanisms hinders a deterministic conceptualization of disease causation. The identification of modifiable risk factors that have a causal effect on the incidence of these diseases and their complications is critical to the primary or secondary prevention of metabolic and endocrine diseases.

"Achondroplasia Unveiled: A Comprehensive Exploration of Genetics, Health, and Community" is an extensive treatise delving into the intricate dimensions of Achondroplasia. This comprehensive work serves as an illuminating guide, offering an in-depth understanding of the genetic underpinnings, medical intricacies, and holistic aspects surrounding this condition. Within its pages, readers embark on a journey through the historical context and definition of Achondroplasia, tracing its genetic origins and modes of inheritance. The treatise meticulously unravels the mysteries of the FGFR3 gene mutations, shedding light on their impact on skeletal development and growth regulation. Each chapter navigates through epidemiological insights, unraveling prevalence statistics and global perspectives on Achondroplasia.

Cystic Fibrosis has seen dramatic advances in treatment since the last edition, including targeted cystic fibrosis transmembrane conductance regulator (CFTR) protein modulators for most CFTR gene abnormalities. This new fifth edition is an update and expansion of the rapid clinical and scientific advances in improving prognosis, and the impact of COVID-19, all of which has transformed conventional models of care. It covers basic science, such as how detailed understanding of the biology of the CFTR gene and protein has led to novel and beneficial therapies, as well as all aspects of clinical management in high-, middle- and low-income settings and the voices of individuals with CF from across the world. It will be a useful reference for clinicians, including all levels of trainees, across the whole multidisciplinary team, scientists and students. Key Features • Follows an appealing organization of chapters, by developing fundamental knowledge of the reader before moving on to more complex or developing topics. • Presents a comprehensive, authoritative and up-to-date text, integrating fundamental science and clinical aspects of cystic fibrosis providing an attractive read for clinicians, trainee doctors and scientists. • Draws on global expertise and reflects best evidence-based practice from experts conducting cutting-edge clinical and basic science research from around the world.