Without neon, Las Vegas might still be a sleepy desert town in Nevada and Times Square merely another busy intersection in New York City. Transformed by the installation of these brightly colored signs, these destinations are now world-famous, representing the vibrant heart of popular culture. But for some, neon lighting represents the worst of commercialism. Energized by the conflicting love and hatred people have for neon, Flickering Light explores its technological and intellectual history, from the discovery of the noble gas in late nineteenth-century London to its fading popularity today. Christoph Ribbat follows writers, artists, and musicians—from cultural critic Theodor Adorno, British rock band the Verve, and artist Tracey Emin to Vladimir Nabokov, Langston Hughes, and American country singers—through the neon cities in Europe, America, and Asia, demonstrating how they turned these blinking lights and letters into metaphors of the modern era. He examines how gifted craftsmen carefully sculpted neon advertisements, introducing elegance to modern metropolises during neon’s heyday between the wars followed by its subsequent popularity in Las Vegas during the 1950s and '60s. Ribbat ends with a melancholy discussion of neon’s decline, describing how these glowing signs and installations came to be seen as dated and characteristic of run-down neighborhoods. From elaborate neon lighting displays to neglected diner signs with unlit letters, Flickering Light tells the engrossing story of how a glowing tube of gas took over the world—and faded almost as quickly as it arrived.

The introduction of artificial lighting extends the time of wakefulness after dark and enables work at night, thus disturbing the human circadian rhythm. The understanding of the physiological mechanisms of visual and non-visual systems may be important for the development and use of proper light infrastructure and light interventions for different workplace settings, especially for shift work conditions. Visual and Non-Visual Effects of Light: Working Environment and Well-Being presents the impact of lighting in the working environment on human health, well-being and visual performance. The physiological explanation of the visual and non-visual effects of light on humans which discusses the biological bases of image and non-image forming vision at the cellular level may be of particular interest to any professional in the field of medicine, physiology, and biology. It is one of the intentions of this book to put forward some recommendations and examples of lighting design which take into account both the visual and non-visual effects of light on humans. These may be of particular interest to any professional in the field of lighting, occupational safety and health, and interior design. "What effects on health can a light ‘overdose’ or light deficiency have? What is bad light? The authors of the monograph provide answers to these questions. Just as for a physicist, the dual nature of light comprises an electromagnetic wave and a photon, the duality of light for a physician comprises visual and non-visual effects." --------------------------------------------------------Prof Jacek Przybylski, Medical University of Warsaw "This is a unique publication in the field of lighting technology. The authors have skillfully combined both the technical and biomedical aspects involved, which is unprecedented in the literature available. As a result, an important study has been created for many professional groups, with a significant impact on the assessment of risks associated with LED sources." --------------------------------------------Prof Andrzej Zając, Military University of Technology, Warsaw

This book is a survey of knowledge about binocular vision, with an emphasis on its role in the perception of a three-dimensional world. The primary interest is biological vision. In each chapter, physiological, behavioral, and computational approaches are reviewed in some detail, discussed, and interrelated. The authors describe experiments required to answer specific questions and relates them to new terminologies and current theoretical schemes.

Cilia: From Mechanisms to Disease, Part A, Volume 175 in the Methods in Cell Biology series, offers a range of techniques and protocols that can be used to study aspects of this interesting cellular organelle both in vitro and in vivo. Sections in this new release include Protocols to induce and study ciliogenesis, Flow Cytometry-Based Approach for the study of primary Cilia, Microscopic observation of human airway ciliary movement using wheat germ agglutinin, Time-lapse imaging of primary cilia behavior with physiological expression of fluorescent ciliary proteins, Evaluation of ciliary-GPCR dynamics using a validated organotypic brain slice culture method, and much more. Other sections cover Studying the morphology, composition and function of the photoreceptor primary cilium in zebrafish, Visualizing Multiciliated Cells in the Zebrafish, Isolation of Ciliary Ectosomes and Analysis of Peptide-mediated Chemotaxis in Chlamydomonas, Using Paramecium as a Model for Ciliopathies, Using organoids to study cilia, Using in vivo cerebellar electroporation to study neuronal cell proliferation and differentiation in a Joubert syndrome mouse model, and more. - Offers a detailed overview of the protocols used to study cilia structure and various aspects of ciliary function - Provides an approach to the study of some diseases related to ciliary dysfunction, also known as ciliopathies - Written in an accessible style by renowned experts in the field

The blinding diseases of inherited retinal degenerations have no treatments, and age-related macular degeneration has no cures, despite the fact that it is an epidemic among the elderly, with 1 in 3-4 affected by the age of 70. The RD Symposium will focus on the exciting new developments aimed at understanding these diseases and providing therapies for them. Since most major scientists in the field of retinal degenerations attend the biennial RD Symposia, they are known by most as the “best” and “most important” meetings in the field. The volume will present representative state-of-the-art research in almost all areas of retinal degenerations, ranging from cytopathologic, physiologic, diagnostic and clinical aspects; animal models; mechanisms of cell death; candidate genes, cloning, mapping and other aspects of molecular genetics; and developing potential therapeutic measures such as gene therapy and neuroprotective agents for potential pharmaceutical therapy. While advances in these areas of retinal degenerations will be described, there will be many new topics that either were in their infancy or did not exist at the time of the last RD Symposium, RD2014. These include the role of inflammation and immunity, as well as other basic mechanisms, in age-related macular degeneration, several new aspects of gene therapy, and revolutionary new imaging and functional testing that will have a huge impact on the diagnosis and following the course of retinal degenerations, as well as to provide new quantitative endpoints for clinical trials. The retina is an approachable part of the central nervous system (CNS), and there is a major interest in neuroprotective and gene therapy for CNS diseases and neurodegenerations, in general. It should be noted that with successful and exciting initial clinical trials in neuroprotective and gene therapy, including the restoration of sight in blind children, the retinal degeneration therapies are leading the way towards new therapeutic measures for neurodegenerations of the CNS. Many of the successes recently reported in these areas of retinal degeneration sprang from collaborations established at previous RD Symposia, and many of those will be reported at the RD2018 meeting and included in the proposed volume. We anticipate the excitement of those working in the field and those afflicted with retinal degenerations will be reflected in the volume.

Mastering the Nikon D500 by Darrell Young provides a wealth of experience-based information and insights for owners of the new D500 camera. Darrell is determined to help the user navigate past the confusion that often comes with complex and powerful professional camera equipment. This book explores the features and capabilities of the camera in a way that far surpasses the user’s manual. It guides readers through the camera features with step-by-step setting adjustments; color illustrations; and detailed how, when, and why explanations for each option. Every button, dial, switch, and menu configuration setting is explored in a user-friendly manner, with suggestions for setup according to various shooting styles. Darrell’s friendly and informative writing style allows readers to easily follow directions while feeling as if a friend dropped in to share his knowledge. The information in this book goes beyond the camera itself and also covers basic photography technique.

The magnetosphere is an intrinsic component of the Earth environment, and travel beyond this sphere will expose man to near absence of a magnetic field. The present study is a continuation of a previous investigation of the physiological and psychological effects of prolonged exposure of man to low intensity magnetic fields. In support of previous findings, a significant gradual decrease of the scotopic flicker fusion threshold was observed from which the subjects recovered after exposure. Problems of life in a magnetic field-free environment are discussed. (Author).

Adequate blood supply to the eye is an important prerequisite for normal visual function. Over the past 40 years our knowledge of ocular blood flow regulation has improved significantly. This reader-friendly textbook provides a comprehensive overview of the current knowledge of ocular blood flow. Lavishly illustrated, it evaluates the wide array of methods that have been used to measure ocular blood flow. Furthermore, it not only offers the reader an evidence-based summary of the physiological and pharmacological properties of ocular blood flow regulation, but also demonstrates the ocular blood flow abnormalities in different vascular diseases. This book will enhance the understanding of all who are interested in learning more about ocular blood flow in health and disease.