This book describes how epigenetic context, in a large sense, affects gene expression and the development of an organism, using the asymptotic limit theorems of information theory to construct statistical models useful in data analysis. The approach allows deep understanding of how embedding context affects development. We find that epigenetic information sources act as tunable catalysts, directing ontogeny into characteristic pathways, a perspective having important implications for epigenetic epidemiology. In sum, environmental stressors can induce a broad spectrum of developmental dysfunctions, and the book explores a number of pandemic chronic diseases, using U.S. data at different scales and levels of organization. In particular, we find the legacy of slavery has been grossly compounded by accelerating industrial decline and urban decay. Individual chapters are dedicated to obesity and its sequelae, coronary heart disease, cancer, mental disorders, autoimmune dysfunction, Alzheimer’s disease, and other conditions. Developmental disorders are driven by environmental factors channeled by historical trajectory and are unlikely to respond to medical interventions at the population level in the face of persistent individual and community stress. Drugs powerful enough to affect deleterious epigenetic programming will likely have side effects leading to shortened lifespan. Addressing chronic conditions and developmental disorders requires significant large-scale changes in public policy and resource allocation.

Events of the past two decades have challenged many of the fundamental beliefs, institutions, and values of modern western culture--the culture of "progress." Are science and technology really progressive and beneficial? Have they led to the enhancement of welfare, greater hapiness, and moral immprovement? I s the continued growth of material productivity possible? Desirable? Are the institutions of progress viable? Progress and Its Discontents assembles the views on progress of some of America's leading humanists, scientists, and social scientists. Citing disappointed expectations of progress in spheres from science to morals and politics, and the many problems created or left untouched by progress, the editors conclude that the term no longer refers to "an inevitable sequence of improvements" but rather to "an aspiration and compelling obligation." Contributors: Nannerl O. Keohane Georg G. Iggers Alfred G. Meyer Crawford Young Francisco J. Ayala John T. Edsall Gerald Fenberg Bernard D. Davis Gerald Holton Marc J. Roberts H. Stuart Hughes Moses Abramovitz Harvey Brooks Nathan Rosenberg Hollis B. Chenery Gianfranco Poggi Aaron Wildavsky G. Bingham Powell, Jr. Samuel H. Barnes Steven Marcus Murray Krieger Robert C. Elliott Martin E. Marty Daniel Bell Frederick A. Olafson This title is part of UC Press's Voices Revived program, which commemorates University of California Press’s mission to seek out and cultivate the brightest minds and give them voice, reach, and impact. Drawing on a backlist dating to 1893, Voices Revived makes high-quality, peer-reviewed scholarship accessible once again using print-on-demand technology. This title was originally published in 1982.

This book applies cutting-edge methods from cognitive and evolutionary theories to develop models of conflict between hierarchically-structured cognitive entities under circumstances of imprecision, uncertainty and stress. Characterized as friction and the fog-of-war by the Prussian military theorist Carl von Clausewitz, such conditions impair institutional cognition in real-time conflict and pose a real and continuing threat to organizations, such as the US military. In a linked collection of formal essays and a mathematical appendix, the book explores different aspects of cognitive and evolutionary process as conducted under the direction of doctrine that acts as a kind of genome for retention of what is learned through Lamarckian evolutionary selection pressures: armies and corporate entities learn from conflict, and incorporate that learning into their ongoing procedures. The book proposes models and policy solutions for strategic competence. A central feature of the book is a formal description of the famous OODA loop of the US military theorist John Boyd in terms of the Data Rate Theorem that links control and information theories. That description is expanded to cover more fully the impact of stochastic fog-of-war effects on tactical and operational scales of conflict. Subsequent chapters examine in more detail the role of doctrine, and the particular effect of embedding culture on cognitive and Lamarckian evolutionary processes associated with conflict on tactical, operational, and strategic scales and levels of organization. A scientifically sophisticated exercise in applied mathematics, history, evolutionary theory, and ecosystem theory, this book will be appropriate for researchers and students interested in defense, security, and international relations, as well as non-academic career professionals in government and industry.

This book explores mental disorders from a uniquely evolutionary perspective. Although there have been many attempts to mathematically model neural processes and, to some extent, their dysfunction, there is very little literature that models mental function within a sociocultural, socioeconomic, and environmental context. Addressing this gap in the extant literature, this book explores essential aspects of mental disorders, recognizing the ubiquitous role played by the exaptation of crosstalk between cognitive modules at many different scales and levels of organization, the missing heritability of complex diseases, and cultural epigenetics. Further, it introduces readers to valuable control theory tools that permit the exploration of the environmental induction of neurodevelopmental disorders, as well as the study of the synergism between culture, psychopathology and sleep disorders, offering a distinctively unique resource.

The creation of economic institutions that can function well under substantial uncertainties -- Black Swans -- is analogous to the dilemmas confronting our hunter-gatherer forefathers in the face of large-scale ecological unpredictability. The ultimate solution was not the development of a super hunter-gatherer technology that could ride out repeated catastrophe, but rather the invention, in neolithic times, of culturally-adapted 'farmed' ecosystems constructed to maximize food yield and minimize risks of famine. Recent advances in evolutionary and ecosystem theory applied to economic structure and process may permit construction of both new economic theory and new tools for data analysis that can help in the design of more robust economic institutions. This may result in less frequent and less disruptive transitions, and enable the design of culturally-specific systems less affected by those that do occur. This unique and innovative book applies cutting-edge methods from cognitive science and evolutionary theory to the problem of the necessary stabilization of economic processes. At the core of this book is the establishment of a statistics-like toolbox for the study of empirical data that is consistent with generalized evolutionary approaches. This toolbox enables the construction of both new economic theories and methods of data analysis that can help in the design of more robust economic institutions. This in turn will result in less frequent and less disruptive Black Swans, and enable as well the design of culturally-specific systems less affected by those that do occur.

From the ‘punctuated equilibrium' of Eldrege and Gould, through Lewontin's ‘triple helix' and the various visions and revisions of the Extended Evolutionary Synthesis (EES) of Laland and others, both data and theory have demanded an opening-up of the 1950's Evolutionary Synthesis that so firmly wedded evolutionary theory to the mathematics of gene frequency analysis. It can, however, be argued that a single deep and comprehensive mathematical theory may simply not be possible for the almost infinite varieties of evolutionary process active at and across the full range of scales of biological, social, institutional, and cultural phenomena. Indeed, the case history of 'meme theory' should have raised a red flag that narrow gene-centered models of evolutionary process may indeed have serious limitations. What is attempted here is less grand, but still broader than a gene-centered analysis. Following the instruction of Maturana and Varela that all living systems are cognitive, in a certain sense, and that living as a process is a process of cognition, the asymptotic limit theorems of information and control theories that bound all cognition provide a basis for constructing an only modestly deep but wider-ranging series of probability models that might be converted into useful statistical tools for the analysis of observational and experimental data related to evolutionary process. The line of argument in this series of interrelated essays proves to be surprisingly direct.

The author argues that to understand mental illness fully requires more than a study of biological models of mental processes and pathologies. He stresses that the causes of human mental disorders are to be found in human interactions.

The scientific and therapeutic implications of a new way of understanding a common disease. Depression has often been studied, but this multifaceted disease remains far from understood. Here, leading researchers present a major new view of the disorder that synthesizes multiple lines of scientific evidence from neurobiology, mindfulness, and genetics. A comprehensive mind-body approach to understanding, evaluating, and treating this disease.

Examines how the philosophy of biology has evolved to our current understanding.

While growing older is inevitable, many of the troubles we associate with aging--including dementia, disability, and an increased dependence on others--are not. The choices we make now can help us to maintain our vitality, a sharp mind, and our independence as we age. Filled with simple, everyday actions we can take to avoid disease, promote vitality, and prevent dementia and late onset Alzheimer's, The Aging Brain is an easy-to-use guide to maintaining brain and body health throughout our lives. Based on solid, up-to-date scientific research, the interventions explained in this book not only prevent progression toward dementia even in those who have already shown mild cognitive impairment, they also reduce disability and depression and keep people living independently longer than those who do not practice these methods. For anyone hoping to slow the aging process, as well as anyone who acts as a caregiver to someone at risk of or already beginning to suffer from dementia and other age-related diseases, this book offers a hopeful, healthy way forward.