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BOOK EXCERPT:
Genetic Analysis of Complex Diseases An up-to-date and complete treatment of the strategies, designs and analysis methods for studying complex genetic disease in human beings In the newly revised Third Edition of Genetic Analysis of Complex Diseases, a team of distinguished geneticists delivers a comprehensive introduction to the most relevant strategies, designs and methods of analysis for the study of complex genetic disease in humans. The book focuses on concepts and designs, thereby offering readers a broad understanding of common problems and solutions in the field based on successful applications in the design and execution of genetic studies. This edited volume contains contributions from some of the leading voices in the area and presents new chapters on high-throughput genomic sequencing, copy-number variant analysis and epigenetic studies. Providing clear and easily referenced overviews of the considerations involved in genetic analysis of complex human genetic disease, including sampling, design, data collection, linkage and association studies and social, legal and ethical issues. Genetic Analysis of Complex Diseases also provides: A thorough introduction to study design for the identification of genes in complex traits Comprehensive explorations of basic concepts in genetics, disease phenotype definition and the determination of the genetic components of disease Practical discussions of modern bioinformatics tools for analysis of genetic data Reflecting on responsible conduct of research in genetic studies, as well as linkage analysis and data management New expanded chapter on complex genetic interactions This latest edition of Genetic Analysis of Complex Diseases is a must-read resource for molecular biologists, human geneticists, genetic epidemiologists and pharmaceutical researchers. It is also invaluable for graduate students taking courses in statistical genetics or genetic epidemiology.
Product Details :
Genre |
: Science |
Author |
: William K. Scott |
Publisher |
: John Wiley & Sons |
Release |
: 2021-12-06 |
File |
: 340 Pages |
ISBN-13 |
: 9781118123911 |
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BOOK EXCERPT:
Second Edition features the latest tools for uncovering thegenetic basis of human disease The Second Edition of this landmark publication bringstogether a team of leading experts in the field to thoroughlyupdate the publication. Readers will discover the tremendousadvances made in human genetics in the seven years that haveelapsed since the First Edition. Once again, the editorshave assembled a comprehensive introduction to the strategies,designs, and methods of analysis for the discovery of genes incommon and genetically complex traits. The growing social, legal,and ethical issues surrounding the field are thoroughly examined aswell. Rather than focusing on technical details or particularmethodologies, the editors take a broader approach that emphasizesconcepts and experimental design. Readers familiar with theFirst Edition will find new and cutting-edge materialincorporated into the text: Updated presentations of bioinformatics, multiple comparisons,sample size requirements, parametric linkage analysis, case-controland family-based approaches, and genomic screening New methods for analysis of gene-gene and gene-environmentinteractions A completely rewritten and updated chapter on determininggenetic components of disease New chapters covering molecular genomic approaches such asmicroarray and SAGE analyses using single nucleotide polymorphism(SNP) and cDNA expression data, as well as quantitative trait loci(QTL) mapping The editors, two of the world's leading genetic epidemiologists,have ensured that each chapter adheres to a consistent and highstandard. Each one includes all-new discussion questions andpractical examples. Chapter summaries highlight key points, and alist of references for each chapter opens the door to furtherinvestigation of specific topics. Molecular biologists, human geneticists, geneticepidemiologists, and clinical and pharmaceutical researchers willfind the Second Edition a helpful guide to understanding thegenetic basis of human disease, with its new tools for detectingrisk factors and discovering treatment strategies.
Product Details :
Genre |
: Science |
Author |
: Jonathan L. Haines |
Publisher |
: John Wiley & Sons |
Release |
: 2007-02-26 |
File |
: 507 Pages |
ISBN-13 |
: 9780471781134 |
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Product Details :
Genre |
: Affective disorders |
Author |
: |
Publisher |
: |
Release |
: 1989 |
File |
: 174 Pages |
ISBN-13 |
: UOM:39015018987001 |
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BOOK EXCERPT:
This trailblazing resource on biomedical informatics provides medical researchers with innovative techniques for integrating and federating data from clinical and molecular studies. This volume helps researchers manage data, expedite their efforts, and make the most of targeted basic research.
Product Details :
Genre |
: Computers |
Author |
: Hai Hu |
Publisher |
: Artech House |
Release |
: 2008 |
File |
: 279 Pages |
ISBN-13 |
: 9781596930391 |
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BOOK EXCERPT:
Product Details :
Genre |
: |
Author |
: Xiaoyun Zhong |
Publisher |
: |
Release |
: 2003 |
File |
: 370 Pages |
ISBN-13 |
: UCAL:X66449 |
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BOOK EXCERPT:
Bioinformatics is an integrative field of computer science, genetics, genomics, proteomics, and statistics, which has undoubtedly revolutionized the study of biology and medicine in past decades. It mainly assists in modeling, predicting and interpreting large multidimensional biological data by utilizing advanced computational methods. Despite its enormous potential, bioinformatics is not widely integrated into the academic curriculum as most life science students and researchers are still not equipped with the necessary knowledge to take advantage of this powerful tool. Hence, the primary purpose of our book is to supplement this unmet need by providing an easily accessible platform for students and researchers starting their career in life sciences. This book aims to avoid sophisticated computational algorithms and programming. Instead, it focuses on simple DIY analysis and interpretation of biological data with personal computers. Our belief is that once the beginners acquire these basic skillsets, they will be able to handle most of the bioinformatics tools for their research work and to better understand their experimental outcomes. Our second title of this volume set In Silico Life Sciences: Medicine provides hands-on experience in analyzing high throughput molecular data for the diagnosis, prognosis, and treatment of monogenic or polygenic human diseases. The key concepts in this volume include risk factor assessment, genetic tests and result interpretation, personalized medicine, and drug discovery. This volume is expected to train readers in both single and multi-dimensional biological analysis using open data sets, and provides a unique learning experience through clinical scenarios and case studies.
Product Details :
Genre |
: Science |
Author |
: Noor Ahmad Shaik |
Publisher |
: Springer Nature |
Release |
: 2019-10-18 |
File |
: 316 Pages |
ISBN-13 |
: 9783030183752 |
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Product Details :
Genre |
: Environmentally induced diseases |
Author |
: |
Publisher |
: |
Release |
: 1999 |
File |
: 838 Pages |
ISBN-13 |
: PSU:000044359461 |
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BOOK EXCERPT:
This is the first compendium of protocols specifically geared towards genetic variation studies. It includes detailed step-by-step experimental protocols that cover the complete spectrum of genetic variation in humans and model organisms, along with advice on study design and analyzing data.
Product Details :
Genre |
: Human genetics |
Author |
: Michael P. Weiner |
Publisher |
: CSHL Press |
Release |
: 2007 |
File |
: 472 Pages |
ISBN-13 |
: 9780879697808 |
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BOOK EXCERPT:
Product Details :
Genre |
: Biometry |
Author |
: |
Publisher |
: |
Release |
: 1998 |
File |
: 496 Pages |
ISBN-13 |
: UCAL:B5031675 |
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Product Details :
Genre |
: Schizophrenia |
Author |
: |
Publisher |
: |
Release |
: 1994 |
File |
: 436 Pages |
ISBN-13 |
: NWU:35558003358559 |