Hereditary or genetic diseases featuring involuntary movements constitute a major aspect of the practice of neurology, functional neurosurgery, genetics, and many areas of basic and applied neuroscience research. Describing the current knowledge on these disorders, Genetics of Movement Disorders brings together information essential for clinicians, geneticists, and neuroscientists in one source. Utilizing a convenient and accessible format, the book is designed to allow easy identification of relevant information, with the overall organization of topics following established phenotypic classifications of movement disorders such as Parkinsonian syndromes, chorea, ataxia, and major categories of diseases grouped by gene locus. This book broadly appeals to neurologists, neuroscientists, geneticists, as well as cell and molecular biologists and hematologists. - Consistently formatted to present a clinical description of the disorder, followed by an in-depth analysis of the mutation and function of the mutated gene including cellular and animal models - Emphasizes the use of DNA tests for each respective disorder - Provides up-to-date, easily accessible information for clinicians, geneticists, and neuroscientists

This book covers recent developments and possible pitfalls in the diagnosis of genetic movement disorders and related conditions. It is divided into three sections: technical and scientific aspects; clinical aspects with guidance towards work-up; and ethical and legal aspects of genetic testing in a clinical and research setting. The first section includes chapters on genetic analysis and counselling with critical discussion of potential problems when interpreting the results. Clinical chapters summarize genetic forms of movement disorders including parkinsonism, tics and dystonia with algorithms for hands-on daily practice. Related conditions such as RLS, ataxias and dementias are also covered. Finally, chapters on ethical and legal aspects of genetic testing are included. Movement Disorder Genetics is aimed at clinicians and scientists working in the field of movement disorders and related conditions.

The use of animal models is a key aspect of scientific research in numerous fields of medicine. This book vigorously examines the important contributions and application of animal models to the understanding of human movement disorders and will serve as an essential resource for basic neuroscientists engaged in movement disorders research. Academic clinicians, translational researchers and basic scientists are brought together to connect experimental findings made in different animal models to the clinical features, pathophysiology and treatment of human movement disorders. A vital feature of this book is an accompanying DVD with video clips of human movement disorders and their corresponding animal models. The book is divided into sections on Parkinson disease, Huntington disease, dystonia, tremor, paroxysmal movement disorders, ataxia, myoclonus, restless legs syndrome, drug-induced movement disorders, multiple system atrophy, progressive supranuclear palsy/corticobasal degeneration and spasticity. This book serves as an essential resource for both clinicians interested in the science being generated with animal models and basic scientists studying the pathogenesis of particular movement disorders.* Provides a single comprehensive resource on animal models of movement disorders that academic clinicians, translational researchers, and basic neuroscientists can refer to* Includes contributions by expert movement disorder clinicians and top-level researchers in the field* Features a DVD containing over 170 video clips of human movement disorders and the corresponding animal models

This book offers a comprehensive approach to the wide range of movement disorders, an important specialty in the field of neurology, guiding readers from the phenomenology to diagnosis and management. Reflecting the latest developments in the field, it offers a unique summary of this dynamic area by pursuing a uniform approach to movement disorders curricula. Divided into three parts, Movement Disorders Curricula provides an authoritative overview of this growing branch of neurology. The first part presents the basic elements of movement disorders, including descriptions of the anatomy and physiology of the basal ganglia. It also features sections on clinical trials for movement disorders, practical skills, and rating scales. The second and third part examine in detail hypokinetic and hyperkinetic movement disorders, respectively. Equipping readers with the practical and research skills needed in the movement disorders field, the book offers a valuable tool to help them prepare for board examinations on general neurology, as well as for fellowships in movement disorders.

Movement Disorders in Childhood, Third Edition provides the most up-to-date information on the diseases and disorders that affect motor control, an important area of specialization within child neurology. In this new edition, each chapter has been fully revised to include all of the latest scientific and therapeutic advances. Updates include new insights in motor development, control, goal-directed and habitual behaviors, classifications of movements and their complex and integrated circuitry. The authors also discuss developments in pathophysiologic mechanisms, immunology and metabolic disorders. New chapters include coverage of genetics of movement disorders and movement disorders in psychiatric conditions.Appendices include an updated and revised drug index and genetic search strategy. An updated Companion website hosts selected educational videos to help diagnose movement disorders. - Provides the only current reference specifically focused on childhood movement disorders - Investigates the underlying etiologies and mechanisms of these disorders - Revised and updated with new materials and a more disease-oriented approach - Contains new chapters on the genetics of movement disorders and movement disorders in psychiatric conditions - Includes new videos of instructive and unusual childhood movement disorders

Marsden's Book of Movement Disorders covers the full breadth of movement disorders, from the underlying anatomy and understanding of basal ganglia function to the diagnosis and management of specific movement disorders, including the more common conditions such as Parkinson's Disease through to very rare conditions such as Niemann-Pick disease.

​This book presents a comprehensive, practical approach to the evaluation of movement disorders using phenomenological basic principles, new discoveries in phenomenological research, and core values of outpatient neurology. Movement Disorders Phenomenology begins with an overview of phenomenology and common approaches to movement disorder patients. Subsequent chapters then accurately and concisely relay information on major hypokinetic disorders such as atypical Parkinsonism, idiopathic Parkinson’s disease, cortical myoclonus, and complex motor tics. Expertly written text is further supplemented by patient vignettes at the beginning of select chapter that focus the reader's attention and highlight the urgency of the problem. These high quality videos aid in the astute clinical diagnosis of many movement disorders that are still largely dependent on visual pattern recognition in the clinic. The book closes with a timely discussion on the role of genetics in movement disorders. Written for the practicing physician, Movement Disorders Phenomenology is an indispensable reference for neurology residents, general neurologists, movement disorders fellows and clinicians, and to any clinician who encounters and evaluates patients in the outpatient arena.

Movement disorders in neurology concern involuntary movements of parts of the body. Many movement disorders are caused by nerve diseases such as Parkinson’s disease. Other causes include injuries, autoimmune diseases, infections and certain medicines. Many movement disorders are inherited so run in families (MedlinePlus). This book is a comprehensive guide to movement disorders for practising neurologists and trainees. Divided into 55 chapters, it discusses the basic science, clinical concepts, diagnosis and treatment of numerous conditions. Parkinson’s disease is covered in-depth and complete chapters are dedicated to movement disorders in children, MR imaging, and emergencies in movement disorders. Presented in an easy to read format, this manual includes 800 clinical photographs, illustrations and tables, as well as extensive references for each chapter. Key points Comprehensive guide to movement disorders for practising neurologists and trainees Parkinson’s disease covered in-depth Includes 800 images, illustrations and tables Extensive references for each chapter

“This updated edition, with its latest treatments and a primer on deep brain stimulation, is helpful for clinicians dealing with movement disorders. It will be an excellent addition to the library of those who see movement disorders." ---Doody's Review Service, 5 stars Revised Third Edition of the practical yet authoritative guide to diagnosis and treatment of movement disorders. Written in an expanded outline format, this book is packed with flow charts, algorithms, and tables to provide quick access to point-of-care information. Easy-to-read and thoroughly up-to-date, this new edition includes the latest diagnostic and treatment protocols, recent FDA-approved drugs, and non-pharmacological therapies. With coverage of all major disease categories, this essential handbook belongs in the pocket of any clinician who suspects a movement disorder in a patient. The book is organized by medical, behavioral, surgical, and non-pharmacological treatment approaches to movement disorders. Opening chapters walk the practitioner through clinical presentation, diagnosis, and work-up of common and uncommon disorders, sleep-related movement disorders, eye and vestibular function, including pediatric issues. Behavioral and psychiatric complications for Parkinson disease, Huntington disease, and Tourette syndrome follow, with a fully reconfigured chapter on functional movement disorders, incorporating changes in classification and treatment approach. Expanded chapters on surgical devices and indications address deep brain stimulation surgery; lesioning, shunts, and pumps; post-operative care; and neuropsychological, social, and ethical issues. The final section on non-pharmacological approaches covers physical and occupational therapy, speech and swallowing therapy, nutrition, and palliative care. Key Features: Thoroughly revised and updated third edition of popular practical resource for busy clinicians Incorporates most recent evidence for the pharmacological, behavioral, surgical, and non-pharmacological treatment of the full spectrum of movement disorders Expanded bullet-point outline format for quick access to essential information Loaded with illustrative flow charts, algorithms, and tables outlining drug dosing, side effects, and other therapeutic treatments

Consumer health information about diagnosis, treatment, and management of Parkinson disease and other hypokinetic and hyperkinetic movement disorders, along with advice for family members and caregivers.