A huge amount of fixed and paraffin-embedded tissue is stored in every hospital. This is very precious material that can be used for translational research and for diagnostics. The molecular methods employed for analysis of these tissues are similar to the usual molecular biology and proteomics methods, but reliable results can be obtained only if specific steps are followed with great care. This book provides detailed and precise guidelines for molecular analysis of archive tissues and will serve as an invaluable aid for researchers and pathologists involved in translational research and diagnostics. Clear notes and explanations are included to simplify use of the protocols for the less experienced. The authors are a group of acknowledged experts who have developed the described methods and validated them within the European project "Archive Tissues: Improving Molecular Medicine Research and Clinical Practice - IMPACTS", which has involved 21 leading institutions in 11 countries.

We are pleased to introduce the collection Pathology & Oncology Research – Editors' Picks from 2021. This collection showcases the most well-received stand-alone articles published in 2021, selected with care by our Editors-in-Chief and Associate Editors. The work presented here highlights the broad diversity of research published across the journal and aims to spotlight themes of topical interest. All research presented here displays compelling advancement of the fields of pathology and oncology, as well as work bridging the gap between basic research and clinical medicine. The selected articles cover four main categories: preclinical research, clinical research, oncology, and non-oncology. This collection aims to further support the journal’s strong community of scholars by recognizing highly deserving authors, as well as contributing editors and reviewers.

Clinical Guide to Fish Medicine Designed as a practical resource, Clinical Guide to Fish Medicine provides an evidence-based approach to the veterinary care of fish. This guide—written and edited by experts in the field—contains essential information on husbandry, diagnostics, and case management of bony and cartilaginous fish. This important resource: Provides clinically relevant information on topics such as anatomy, water quality, life-support systems, nutrition, behavioral training, clinical examination, clinical pathology, diagnostic imaging, necropsy techniques, anesthesia and analgesia, surgery, medical treatment, and transport Describes common presenting problems of fish, including possible differentials and practical approaches Reviews key information on non-infectious and infectious diseases of fish in a concise format that is easily accessible in a clinical setting Written for veterinarians, biologists, technicians, specialists, and students, Clinical Guide to Fish Medicine offers a comprehensive review of veterinary medicine of fish.

This book reviews the theoretical concepts and experimental details underpinning the broad range of modern technologies that are currently being used to advance our understanding of the biomolecular sciences.

The series Topics in Current Chemistry Collections presents critical reviews from the journal Topics in Current Chemistry organized in topical volumes. The scope of coverage is all areas of chemical science including the interfaces with related disciplines such as biology, medicine and materials science. The goal of each thematic volume is to give the non-specialist reader, whether in academia or industry, a comprehensive insight into an area where new research is emerging which is of interest to a larger scientific audience.Each review within the volume critically surveys one aspect of that topic and places it within the context of the volume as a whole. The most significant developments of the last 5 to 10 years are presented using selected examples to illustrate the principles discussed. The coverage is not intended to be an exhaustive summary of the field or include large quantities of data, but should rather be conceptual, concentrating on the methodological thinking that will allow the non-specialist reader to understand the information presented. Contributions also offer an outlook on potential future developments in the field.

This first volume chronicles the early stages of the outbreak and world-wide spread of SARS-Cov-2 (COVID-19) and delineates the role of several disciplines in therapeutic and control measures. Documenting the epidemiologic response from China, the clinical evaluation, pathology and intial therapeutics that were available during the first 6 months and onwards of the outbreak, this book records how the response to the pandemic was mounted and how various branches of science and research combined to rapidly expand our understanding of the disease.

Tumors in Domestic Animals, Fifth Edition is a fully revised new edition of the most comprehensive and authoritative reference on veterinary tumor pathology in common domestic animals, now in full color throughout with the most current advances in research and diagnostics. Now in full color with hundreds of exquisite new images showing diagnostic features, pathogenesis, and techniques Adds new sections on relevant clinical pathology and oncology Updated throughout to include the very latest advances in research and diagnostics Takes a logical, user-friendly system approach Written by leading experts on animal tumor pathology

Written by experts from Washington University School of Medicine, this text is a thorough review of the specific molecular genetic techniques that can provide diagnostically useful molecular genetic information on tissue samples—including cytogenetics, fluorescence in situ hybridization (FISH), PCR, electrophoresis and hybridization analysis, DNA sequence analysis, and microarrays. The first part of the book describes each technique, indicates its advantages, disadvantages, capabilities, and limitations, and systematically addresses sensitivity and specificity issues. Subsequent chapters, organized by organ system, detail the specific applications of these tests in surgical pathology. More than 150 full-color and black-and-white illustrations complement the text.

Expertly edited and endorsed by the International Society for Laboratory Hematology, this is the newest international textbook on all aspects of laboratory hematology. Covering both traditional and cutting-edge hematology laboratory technology this book emphasizes international recommendations for testing practices. Illustrative case studies on how technology can be used in patient diagnosis are included. Laboratory Hematology Practice is an invaluable resource for all those working in the field.