An authoritative survey of the scientific background for therapeutic cancer vaccines, the challenges to their development, and their current uses in treating cancer. The authors examine the basic issues that effect all vaccines (such as immune adjuvants and prime-boost strategies), describe the methods for antigen discovery, and review the preclinical development phases for each major vaccine strategy. They also spell out the clinical results for cancer vaccines now beginning to be used in the treatment of many common cancers.

An integrated overview of cancer drug discovery and development from the bench to the clinic, showing with broad strokes and representative examples the drug development process as a network of linked components leading from the discovered target to the ultimate therapeutic product. Following a systems biology approach, the authors explain genomic databases and how to discover oncological targets from them, how then to advance from the gene and transcript to the level of protein biochemistry, how next to move from the chemical realm to that of the living cell and, ultimately, pursue animal modeling and clinical development. Emerging cancer therapeutics including Ritux an, Erbitux, Gleevec Herceptin, Avastin, ABX-EGF, Velcade, Kepivance, Iressa, Tarceva, and Zevalin are addressed. Highlights include cancer genomics, pharmacogenomics, transcriptomics, gene expression analysis, proteomic and enzymatic cancer profiling technologies, and cellular and animal approaches to cancer target validation.

Leading investigators synthesize the entire laboratory and clinical process of developing anticancer drugs to create a single indispensable reference that covers all the steps from the identification of cancer-specific targets to phase III clinical trials. These expert authors provide their best guidance on a wide variety of issues, including clinical trial design, preclinical screening, and the development and validation of bioanalytic methods. The chapters on identifying agents to test in phase III trials and on trial design for the approval of new anticancer agents offer a unique roadmap for moving an agent to NDA submission.

The Vaccine Handbook has a simple purpose- to draw together authoritative information about vaccines into a simple and concise resource that can be used in the office, clinic, and hospital. Not an encyclopedia or scientific textbook, The Vaccine Handbook gives practical advice and provides enough background for the practitioner to understand the recommendations and explain them to his or her patients. For each vaccine, the authors discuss the disease and its epidemiology, the vaccine’s efficacy and safety, and the practical questions most frequently asked about the vaccine’s use. The authors also discuss problems such as allergies, breastfeeding, dosing intervals and missed vaccines, and immunocompromised individuals. This handbook is also available electronically for handheld computers. See Media listing for details.

Vaccines are among modern medicine's greatest triumphs, but popular misunderstandings about vaccines and the communicable diseases they prevent threaten to undo more than a century's worth of progress in public health. Pediatricians, infectious disease specialists, OB/GYN physicians, internists, and family practitioners thus must make patient education about vaccines a routine part of preventative care. THE VACCINE HANDBOOK is a one-stop resource for clinicians whose practices involve administering vaccines. At-a-glance immunization schedules, scripts for addressing patient concerns, and frequently asked questions at the end of each section prepare practitioners to meet challenges such as vaccine hesitancy, correct dosing, and the timing of "catch-up" immunizations with confidence. Covering every clinical scenario from routine childhood immunizations to specialty vaccines for international travel, THE VACCINE HANDBOOK is an essential reference for any preventive care provider. FEATURES · Charts and tables summarizing immunization schedules, proper dosing and storage, and contraindications for commonly used vaccines for quick and easy reference · Vaccination guidelines tailored to special circumstances such as pregnancy, international travel, patients' immunization history, and workplace hazards · Patient education tools including links to reliable online resources and strategies for framing discussions about the benefit of vaccination

This new companion book to AMP's highly successful Everyone's Guide to Cancer Therapy, now in its fourth edition, is a comprehensive hands-on guide for patients and their families who face cancer's many challenges. Knowledge and information provide the greatest tools--and greatest comforts--for anyone fighting cancer or helping a family member or friend who is. Now AMP bolsters that strength-giving arsenal with Everyone's Guide to Cancer Supportive Care. Through more than 50 chapters, cancer care specialists Ernest and Isadora Rosenbaum--along with nearly 80 other medical experts--answer every conceivable question concerning a cancer patient's physical, psychological, and spiritual needs. This extremely effective format first appeared as Supportive Cancer Care (Sourcebooks 2001), but we've completely revised and updated the entire book to reflect the latest care advances and techniques. The wide range of covered topics includes: * Understanding cancer and its treatments * Chemotherapy and bone marrow transplant side effects * Stress and cancer * The will to live * Cancer and spirituality * Sexuality * Nutritional considerations * Rehabilitation and fitness With this book, cancer patients and those who care for them can make informed decisions, face the disease with renewed courage, and care for both their well-being and their bodies. The Rosenbaums provide an incredible source of information and hope in the face of this frightening illness.

Nanomedicine is defined as the application of nanobiotechnology in clinical medicine, which is currently being used to research the pathomechanism of disease, refine molecular diagnostics, and aid in the discovery, development, and delivery of drugs. In The Handbook of Nanomedicine, Third Edition, Prof. Kewal K. Jain updates, reorganizes, and replaces information in the comprehensive second edition in order to capture the most recent advances in this dynamic field. Important components of nanomedicine such as drug delivery via nanobiotechnology and nanopharmaceuticals as well as nanooncology, where the greatest number of advances are occurring, are covered extensively. As this text is aimed at nonmedical scientists, pharmaceutical personnel, as well as physicians, descriptions of the technology involved and other medical terminology are kept as clear and simple as possible. In depth and cutting-edge, The Handbook of Nanomedicine, Third Edition informs its readers of the ever-growing field of nanomedicine, destined to play a significant role in the future of healthcare.

Every chapter of this comprehensive guide has been updated and revised to include the latest medical breakthroughs and advice about cancer treatment. Line drawings.

“Written by two oncologists . . . this authoritative but readable reference stands out . . . as a uniquely comprehensive, thorough source of up-to-date information” (Library Journal). For more than thirty years, Everyone’s Guide to Cancer Therapy has been the definitive resource for anyone confronting a cancer diagnosis. The revised and updated fifth edition draws on the latest research, information, and advice from more than 100 top oncology specialists. Equally informative and accessible, this comprehensive book helps cancer patients and their caregivers navigate through diagnosis, treatment, and supportive care. Topics include: * Information on recently approved targeted therapies for various cancer types * The newest strategies in cancer diagnosis and prevention * Cancer biology: translating scientific discoveries into meaningful advances for patients * Supportive care and complementary approaches

The Cancer Handbook provides a comprehensive overview of scientific and clinical information in cancer research and medicine (oncology). This area is one of the most intensively studied in biology and medicine, resulting in a huge amount of new information being published every year. This book summarizes and explains key facts and recent developments. It is aimed at a wide variety of readers who need easy access to knowledge concerning all major aspects of cancer biology, without too much clinical detail or specialist research material. The Cancer Handbook stands out from existing oncology textbooks and reference works in that it bridges the gap between the molecular biology of cancer and clinical diagnosis and treatment. As more and more laboratory research is applied to clinical management, e.g. the use of monoclonal antibodies as drugs, it is important that clinicians understand the aetiology of the disease and the molecular basis of the new therapeutic approaches. It is also important for laboratory scientists to appreciate the potential applications of their research and the practical issues involved in translating it to clinical practice. For this second edition, all the sections have been fully revised and updated, with new chapters addressing important topics that have gained prominence in recent years. New editors and authors have brought additional expertise to the project. For example, in the section on the Molecular and Cellular Basis of Cancer, there are new chapters on stem cells, epigenetics, and microRNAs, as well as chapters on the links between cancer and development and inflammation. In the Treatment section, the emphasis is now on multidisciplinary team management of different cancers, plus there are new chapters on clinical trial design, RNA interference and rational drug design. The page design and the quality of the diagrams has been improved, with all illustrations now in full colour. The glossary has been made more informative and easy to use.