Biomedical research involving animals remains essential for the advancement of the medical, veterinary, agricultural, and biological sciences. Following in the footsteps of its predecessors, the Handbook of Laboratory Animal Science, Volume II, Third Edition: Animal Models explains in great detail the comparative considerations underlying the choic

This two-volume set presents a comprehensive description of laboratory animal genetics, diseases, health monitoring, nutrition, and the environmental impact on animal testing. It considers the ethics of animal experimentation through a complete review of European and North American legislation on the topic. It discusses alternatives to animal experiments, including the use of isolated organs, cell cultures, and computer simulations. The book also examines general methods, including experimental design and statistical evaluation, non-surgical and surgical techniques, anesthesia, and post-mortem examinations. Reviews of animal models for studying diseases of different organ systems, infectious diseases, cancer, and toxicology are featured as well.

While replacing and reducing the use of laboratory animals are integral parts of the 3Rs—replace, reduce, refine—which form the cornerstones of laboratory animal science, biomedical research involving animals remains absolutely essential for the advancement of the medical, veterinary, agricultural, and biological sciences. Building upon the bestselling previous edition, the Handbook of Laboratory Animal Science, Volume III, Third Edition: Animal Models complements volumes I and II of the third edition by completing the task of providing a comprehensive overview of animal models in all biomedical disciplines. The three Rs have been integrated throughout this handbook to promote efficient and humane experimental work with animals. Written by international experts, each chapter focuses on an important subdiscipline of laboratory animal science and can be used as a stand-alone text. This volume contains new chapters for six additional disease animal models: spinal cord injury, cardiovascular diseases, sudden infant death syndrome, developmental disorders, eye diseases, and human cancer. It also presents a new chapter on applying reduction and refinement to animal models. This handbook can be used for undergraduate and postgraduate laboratory animal science courses, and as a handbook for scientists who work with animals in their research, for university veterinarians, for regulators, and for other specialists in laboratory animal science.

Laboratory animal testing provides most of our current knowledge of human physiology, microbiology, immunology, pharmacology, and pathology. From studies of genetics in fruit flies to studies of cellular processes in genetically modified mice to recent dramatic developments in genetics, translational research, and personalized medicines, biomedical

The Welfare of Animals used in Research: Practice and Ethics gives a complete and balanced overview of the issues surrounding the use of animals in scientific research. The focus of the book is on the animal welfare implications and ethics of animals in research. It covers the topics with sufficient depth to show a real understanding of varied and complex subjects, but conveys the information in a beautifully reader-friendly manner. Key features: Provides those who are not working in the field with a reasonable understanding as to why and how animals are used in research. Gives an introduction to the ethical issues involved in using animals, and explains how these are addressed in practice. Details the advances in animal welfare and the use and development of the 3Rs principles, and how these have become fundamental to the everyday use and regulation of animals used in research. The focus is on principles making it suitable for an international audience. This book is a useful introduction to the issues involved in laboratory animal welfare for those who intend to work in research involving animals. It is also useful to prospective animal care staff and animal welfare scientists, and to those involved in ethical review. It will help inform debate amongst those who are not involved in experimentation but who are interested in the issues. Published as a part of the prestigious Wiley-Blackwell – UFAW Animal Welfare series. UFAW, founded 1926, is an internationally recognised, independent, scientific and educational animal welfare charity. For full details of all titles available in the series, please visit the UFAW Animal Welfare series website.

While replacing and reducing the use of laboratory animals are integral parts of the 3Rs-replace, reduce, refine-which form the cornerstones of laboratory animal science, biomedical research involving animals remains absolutely essential for the advancement of the medical, veterinary, agricultural, and biological sciences. Building upon the bestsel

The Laboratory Hamster and Gerbil details basic information and common procedures for individuals performing research with hamsters and gerbils. It includes duties of animal facility management, animal husbandry, regulatory compliance, and technical procedures and assists in the humane care and use of hamsters and gerbils in the laboratory. It prov

A respected resource for decades, the Guide for the Care and Use of Laboratory Animals has been updated by a committee of experts, taking into consideration input from the scientific and laboratory animal communities and the public at large. The Guide incorporates new scientific information on common laboratory animals, including aquatic species, and includes extensive references. It is organized around major components of animal use: Key concepts of animal care and use. The Guide sets the framework for the humane care and use of laboratory animals. Animal care and use program. The Guide discusses the concept of a broad Program of Animal Care and Use, including roles and responsibilities of the Institutional Official, Attending Veterinarian and the Institutional Animal Care and Use Committee. Animal environment, husbandry, and management. A chapter on this topic is now divided into sections on terrestrial and aquatic animals and provides recommendations for housing and environment, husbandry, behavioral and population management, and more. Veterinary care. The Guide discusses veterinary care and the responsibilities of the Attending Veterinarian. It includes recommendations on animal procurement and transportation, preventive medicine (including animal biosecurity), and clinical care and management. The Guide addresses distress and pain recognition and relief, and issues surrounding euthanasia. Physical plant. The Guide identifies design issues, providing construction guidelines for functional areas; considerations such as drainage, vibration and noise control, and environmental monitoring; and specialized facilities for animal housing and research needs. The Guide for the Care and Use of Laboratory Animals provides a framework for the judgments required in the management of animal facilities. This updated and expanded resource of proven value will be important to scientists and researchers, veterinarians, animal care personnel, facilities managers, institutional administrators, policy makers involved in research issues, and animal welfare advocates.