Despite being confined to the gastrointestinal tract, the gut microbiome has a wide impact on human physiology, supplementing its host’s biochemistry in a complex symbiotic relationship. Research in the field has evolved rapidly in the last decade, and we are now developing a better understanding of how our gut microbiome can influence our immune systems, metabolism, neurological signaling, and perhaps most unexpectedly, our brains; a phenomenon described as the gut-brain-axis. This book, ‘Handbook of Microbiome and Gut-Brain-Axis in Alzheimer’s Disease’, sets out to explore the complex role of the microbiome with regard to Alzheimer’s disease (AD). The microbiome is a critical and often overlooked aspect of immunity, which in turn plays a role in cognition. The book presents current research into the gut microbiota and its far-reaching impacts on cognitive function and neurodegeneration. Interventions, including probiotic supplementation, fecal transfer, and supplementation with microbial metabolites, are discussed, as is the use of certain probiotics to study the effects of the gut microbiota on behavior and cognitive function, and as potential therapeutics for AD. Other topics covered include the influence of the gut and oral microbiota on immune inflammatory signals: cytokines, neuroendocrine hormones, bacterial components, neuroactive molecules, and microbial metabolites. The book is divided into four sections, each covering a research area pertinent to the gut-brain-axis and its relationship with cognitive function and AD. It will be of interest to all those whose work includes the study and understanding of these complex, multi-variable biological mechanisms, particularly in the context of cognitive function and AD. The cover shows a color edited MRI image of a sagittal section of a neurological control brain of Dr. Giulio Maria Pasinetti.

It is almost 120 years since Alzheimer’s disease (AD) was first reported, and the concept of managing some of the modifiable risk factors associated with the disease has been present from the outset. Intervening to manage risk factors as a way of tackling AD is not new, but optimizing brain health as a way of minimizing risk and maximizing the potential benefits of revolutionary new treatments for AD is becoming increasingly important. This book, the Handbook of Intervention and Alzheimer’s Disease, presents 47 papers exploring factors which may either inspire or inform future treatment and clinical trials. While novel interventions such as anti-amyloid immunotherapy present great opportunities, they may also increase the risk of brain bleeds and edema, which in turn may lead to adverse clinical outcomes. Such adverse outcomes are demonstrably more likely to occur in persons with poor brain health, so improved management of the risk factors which make up the AD preventome will also minimize the risks associated with such novel therapies. The papers in this volume can therefore be thought of as offering insight into those factors that can optimize brain health or providing key insights into interventions which may achieve such outcomes. Together with its companion volume on prevention, the book provides a comprehensive overview of strategies for tackling Alzheimer’s disease, and will be of interest to all those working in the field. Cover illustration: Improved hypoperfusion (resolving blue colors) on ASL MRI Z-score maps superimposed on structural MRI scans at baseline and one year in a PET amyloid-positive research participant with cognitive complaints undergoing one year of multi-domain personalized brain health interventions (vascular disease management, dietary optimization, sustained physical activity etc.). Permission to use this figure was granted both by the study P.I. Dr. David Merrill, MD, PhD, of the Pacific Neuroscience Institute and the research participant.

It is almost 120 years since Alzheimer’s disease (AD) was first reported, and the concept of modifiable risk factors associated with the disease has been present from the outset. Thus, the idea of preventing AD is not new, with reference to strategies noted as early as the 1990s. This subfield of AD research has matured in recent years, with the number of modifiable risk factors – the AD preventome – rising from the 7 initially identified to the current 12, with an estimated contribution to dementia cases worldwide of about 40%. This book, the Handbook of Prevention and Alzheimer’s Disease, introduces physicians, scientists, and other stakeholders to this subfield of AD research. It investigates the AD preventome, which will continue to expand as the understanding of new factors and related biomarkers is refined. Optimizing this preventome leads to an improvement in overall brain health, an outcome which reduces the risk of developing AD and improves quality of life. The book goes on to examine other domains of prevention, from vascular risk factors to social engagement and from sleep health to spirituality. If the journey to end AD can be likened to a long and arduous challenge, understanding every possible part of the overall toolkit of approaches for disease prevention and intervention is essential. Together with its companion volume on intervention, the book provides a comprehensive overview of strategies for tackling Alzheimer’s disease, and will be of interest to all those working in the field. Cover illustration: White matter tracts showing sex differences in connectivity in men versus women as a function of increasing body mass index. Reprinted with permission from Rahmani F, Wang Q, McKay NS, Keefe S, Hantler N, Hornbeck R, Wang Y, Hassenstab J, Schindler S, Xiong C, Morris JC, Benzinger TLS, Raji CA. Sex-Specific Patterns of Body Mass Index Relationship with White Matter Connectivity. J Alzheimers Dis. 2022;86(4):1831-1848. doi: 10.3233/JAD-215329. PMID: 35180116; PMCID: PMC9108572.

Tryptamine Microbiota-Deregulated Aminoacyl-tRNA Biosynthesis: A Conceptual Evolution of the Role of Microbiota Tryptamine in Human Diseases provides a detailed investigation into tryptamine, its underlying mechanisms, and metabolism across multiple diseases. The book explores key concepts of tryptamine, its biosynthetic pathways, and its influence in disease, specifically focusing on the Alzheimer's disease-associated gut bacterial sequence (ADAS). Various neurodegenerative conditions are covered alongside cancer, diabetes, infections, and chromosomal aberrations. Additionally, a chapter on gut tryptamine in domestic and agricultural animals is included. The book closes with case studies involving FDG-PET imaging in the context of tryptamine-treated mouse models and Alzheimer's disease patients.This book elucidates the implications of the gut microbiota-mediated tryptamine metabolism for human health, sharing insights into disease etiology, mechanisms, testing, prevention, and treatment. It is an ideal reference for researchers across the biomedical sciences. - Provides a detailed investigation into tryptamine and its role in human health - Explores the relationship between microbiome tryptamine metabolome and a range of diseases, including diabetes, cancer, Alzheimer's disease and Parkinson's disease - Considers the role of tryptamine in cell death and the impairment of genome activities - Paves the way for advances in disease prevention and treatment pathways

This handbook focuses on different aspects of anti-aging and both preventive and regenerative medicine. It includes analysis of the paradigm of ageing and concepts of anti-aging medicine. Standards and technologies are highlighted in over twenty chapters all authored by international experts in regenerative medicine. Topics covered include: • Ageing, aging, and anti-aging: A Decalogue for anti-aging medicine • Lessons from Sicilian centenarians for anti-aging medicine • Molecular biomarkers and genetic aspects of aging • Future of peptides in clinical practice • Mitochondrial approaches in anti-aging medicine and in SARS-CoV2 infection • Tissue-specific autoantibodies in preventive medicine • Chronic stress as a psycho-neuro-immunological dysfunction • Gut-associated immune system and its health implications • Regenerative medicine with platelet-rich-plasma • Alzheimer’s disease: Preventive and anti-aging neurology • Autistic spectrum disorder and mitochondrial medicine • Integrative hormonal approach in anti-aging medicine • Preventive cardiology and phlebology • Aesthetic and anti-aging medicine • Preventive ophthalmology • Preventive oncology • Nutrition in healthy aging • Physical activity and fitness paradigms for anti-aging and longevity Recommended reading for clinicians working in anti-aging medicine as well as ageing people. The authors hope it will set a new “standard of anti-aging medicine” and as a tool in planning for the inevitable challenges we all will face caring for ageing patients and creating preventive-health programs.

An essential treatment of nutraceuticals and natural products, their preparation techniques, and applications In Handbook of Nutraceuticals and Natural Products: From Concepts to Application, a team of distinguished researchers delivers a one-stop resource describing the preparation techniques and functional uses of nutraceuticals and natural products with a focus on the technologies involved. The book includes coverage of the biological, medicinal, and nutritional properties and applications of functional foods, as well as the advanced technologies used in the extraction and functionalization of nano components and the nanomaterial and nanochemical aspects of the products. The authors discuss developmental research as well as user-level benefits of nutraceuticals and natural products and thoroughly review the market analyses, quality assurance processes, and regulations relevant to nutraceuticals and natural products. They also cover: Thorough introductions to nutraceuticals, functional foods, liposomal technology, prebiotics, and lycopene and its active drug delivery Comprehensive explorations of nutraceutical compounds from marine microalgae and poly lysine as an antimicrobial agent Practical discussions of a nutraceuticals approach to treating cancer-cachexia and early life nutrition and epigenetics In-depth examinations of encapsulation and delivery of nutraceuticals and bioactive compounds by nanoliposomes and tocosomes as promising nanocarriers Perfect for chemists, biochemists, food scientists, and materials scientists, Nutraceuticals and Natural Products: From Concepts to Application will also earn a place in the libraries of medical scientists working in academia or industry, as well as nutritionists, dietitians, and biochemistry graduate students studying nutraceuticals.

The handbook examines the latest research and clinical advancements in assessing and treating ADHD (attention deficit hyperactivity disorder) across the lifespan. It synthesizes the most current research data and trends combined with best-practice interventions to form a comprehensive, state-of-the-art resource. The handbook identifies the most relevant, effective treatments for individuals with ADHD. Key areas of coverage include: Core symptoms of ADHD in minority children. Lifestyles for children with ADHD. Digital interventions for children and adolescents with ADHD. Telemedicine to manage ADHD across the lifespan. Healthcare use and costs for adults with ADHD. The Clinical Handbook of ADHD Assessment and Treatment Across the Lifespan is an essential reference for researchers, professors, and graduate students as well as clinicians and other professionals across such interrelated disciplines as clinical child, school, and developmental psychology, child and adolescent psychiatry, social work, rehabilitation medicine/therapy, pediatrics, and special education.

Handbook of the Biology of Aging, Ninth Edition, provides a comprehensive synthesis and review of the latest and most important advances and themes in modern biogerontology. The book focuses on the trend of 'big data' approaches in the biological sciences, presenting new strategies to analyze, interpret and understand the enormous amounts of information being generated through DNA sequencing, transcriptomic, proteomic, and metabolomics methodologies applied to aging related problems. Sections cover longevity pathways and interventions that modulate aging, innovative tools that facilitate systems-level approaches to aging research, the mTOR pathway and its importance in age-related phenotypes, and much more. - Assists researchers in keeping abreast of research and clinical findings outside their subdiscipline - Helps medical, behavioral and social gerontologists understand what basic scientists and clinicians are discovering - Includes new chapters on genetics, evolutionary biology, bone aging, and epigenetic control - Examines the diverse research being conducted in the study of the biology of aging

Help get your gut back on track with this simple, whole-body plan Your gut encompasses your digestive organs and all their resident microbes—and its health affects all the other systems in your body. Experience the physical and mental benefits of a healthy gut biome with this research-based guide. Find out how to care for your body, alleviate digestive distress, and soothe a wide variety of ailments, from heartburn and irritable bowel syndrome to depression and anxiety. Learn the five principles of good gut health, explore the science of probiotics, and refer to at-a-glance lists of foods to enjoy, limit, or avoid. Go deeper with practical advice for exercise, stress reduction, and mindfulness practices to help boost your overall mood, energy, and even your memory. A holistic 2-week plan—Kick-start your gut health routine with a customizable 2-week plan that incorporates healthy eating, exercise, meditation, and more. Tasty, gut-healthy recipes—Treat your gut right with 50 feel-good options like the Lemon-Ginger Smoothie, Wild Salmon and Fennel Scramble, Fermented Fried Rice with Vegetables, and more. Simple symptom tracking—Use a handy template to track your symptoms, identify possible triggers, and chart your progress as you make changes. Help restore balance in your gut with The Whole-Body Guide to Gut Health.