Designed for quick, everyday reference, Handbook of Targeted Cancer Therapy and Immunotherapy: Gastrointestinal Cancer provides a practical overview of this rapidly advancing field. Comprehensive yet concise, this easy-access resource by Dr. Milind Javle of MD Anderson Cancer Center and Dr. Mitesh J. Board of Mayo Clinic helps you filter and apply the most recent discoveries as they pertain to specific tumor types, actionable molecular targets, and clinical performance of investigational targeted agents and combinations of agents.

Demystifying the science behind new cancer treatments A clear and accessible guide written in everyday language for nurses and other healthcare professionals A Beginner’s Guide to Targeted Cancer Treatments and Cancer Immunotherapy helps readers understand the science behind many of the newer drug treatments for cancer. Assuming only a basic familiarity with cell biology, this easy-to-digest guide describes how our increased understanding of cancer has been translated into the creation of new cancer treatments with a wide range of targets. Gifted communicator and educator Dr. Elaine Vickers helps you understand the mechanisms of a wide range of individual targeted therapies and immunotherapies — enabling you to communicate effectively with your colleagues and patients. Concise chapters explain how new cancer drugs and immunotherapies work, discuss their benefits, identify their limitations, and more. Now in its second edition, this popular handbook is fully revised to reflect the latest developments in targeted drug therapies and immunotherapies. Entirely new chapters on advancements in various immunotherapies are accompanied by more than 100 new and updated color illustrations. Provides an up-to-date overview of relevant treatment targets for all major cancer types, including hematological cancers Describes cancer biology and the relationship between cancer and the immune system Offers valuable insights into cell communication pathways as a common target Covers small molecule drugs, antibody-based treatments, and cellular therapies, including novel immunotherapies A Beginner’s Guide to Targeted Cancer Treatments and Cancer Immunotherapy is a must-have resource for trainees, practicing nurses, and other healthcare professionals involved in the care of cancer patients, as well as non-specialists who encounter cancer data or cancer terminology in their field.

Designed for quick, everyday reference, Handbook of Targeted Cancer Therapy and Immunotherapy: Breast Cancer provides a practical overview of this rapidly advancing field. Comprehensive yet concise, this easy-access resource by Drs. Senthil Damodaran and Debu Tripathy of MD Anderson Cancer Center helps you filter and apply the most recent discoveries as they pertain to specific tumor types, actionable molecular targets, and clinical performance of approved or investigational targeted agents and combinations of agents.

Handbook of Brain Tumor Chemotherapy, Molecular Therapeutics, and Immunotherapy, Second Edition, provides a comprehensive overview of the molecular methodologies in the neuro-oncology field. There have been profound changes in the landscape of approaches to brain tumor therapy since the first edition—mainly in the areas of molecular biology and molecular therapeutics, as well as in the maturation of immunotherapy approaches (e.g., vaccines). This updated edition has a new, primary focus on multidisciplinary molecular methods, and is broadened to include the latest cutting-edge molecular biology, therapeutics, immunobiology and immunotherapy approaches. As the first comprehensive book to address the molecular research into these concepts, users will find it to be an invaluable resource on the topics discussed. - Provides the most up-to-date information regarding conventional forms of cytotoxic chemotherapy, as well as the basic science and clinical application of molecular therapeutics for the treatment of brain tumors - Broadly appeals to anyone interested in neuro-oncology and the treatment of brain tumors - Features updated chapters on molecular biology, molecular therapeutics, maturation of immunotherapy approaches, and a focus on multidisciplinary molecular methods - Includes a new section on the basic science of immunology, as well as thorough updates on the use of vaccine technology and immunotherapy for the treatment of brain tumors

Highly Commended in the category of Oncology at the British Medical Association Awards 2019 The accessible guide to the principles behind new, more targeted drug treatments for cancer Written for anyone who encounters cancer patients, cancer data or cancer terminology, but have no more than a passing knowledge of cell biology. A Beginner's Guide to Targeted Cancer Treatments provides an understanding of how cancer works and the many new treatments available. Using over 100 original illustrations, this accessible handbook covers the biology and mechanisms behind a huge range of targeted drug treatments, including many new immunotherapies. Dr Vickers translates a complex and often overwhelming topic into something digestible and easily understood. She also explains what cancer is, how it behaves and how our understanding of cancer has changed in recent years. Each chapter takes the reader through how new cancer drugs work and their benefits and limitations. With the help of this book, readers will be able to better understand more complex, in-depth articles in journals and books and develop their knowledge. This vital resource: Offers the latest insights into cancer biology Provides a broad understanding of how targeted cancer treatments work Describes many of the new immunotherapy approaches to cancer treatment, such as checkpoint inhibitors and CAR-modified T cells Helps readers feel confident discussing treatment options with colleagues and patients Provides an overview of which treatments are relevant to each of the most common solid tumours and haematological cancers, and the rationale behind them Demystifies the jargon – terms such as the EMT, cancer stem cells, monoclonal antibodies, kinase inhibitors, angiogenesis inhibitors etc. Explains the resistance mechanisms to many new treatments, including issues such as the way cancer cells diversify and evolve and the complex environment in which they live

Gastrointestinal cancers are among the most prevalent malignancies worldwide, with high rate of global cancer incidence and cancer-related death. Gastrointestinal cancers include esophageal cancer, gastric cancer, colorectal cancer, pancreatic cancer, and liver cancer, which all, except the last one, are covered in this volume. The fourth volume of the “Interdisciplinary Cancer Research” series, entitled “Gastrointestinal Cancers: An Interdisciplinary Approach” publishes comprehensive volumes on mechanisms of gastrointestinal cancers and novel immunotherapy opportunities and presents the most updated and peer-reviewed chapters on gastrointestinal cancers therapy. This interdisciplinary series is of special value to researchers working on cell biology, immunology, biochemistry, genetics, and practitioners working on oncology and gastroenterology. This is the main concept of Cancer Immunology Project (CIP), which is a part of Universal Scientific Education and Research Network (USERN). This interdisciplinary book will be of special value for researchers, oncologists, and gastroenterologists who wish to extend their knowledge on gastrointestinal cancers.

There have been many advances in the diagnosis and treatment of cancer, but it is still a feared disease with a lot of work left to be done. The importance of gastrointestinal cancer as a frequently occurring disease goes without saying. It accounts for half of human cancer cases but differs from other forms of cancer. Complete prevention is possible through proper treatment of precancerous lesions. There is still no comprehensive book about prevention, early diagnosis, and proper treatment of precancerous lesions and new developed diagnostic modality, and treatment such as endoscopic treatment and minimal invasive surgery and chemotherapy and immunotherapy. Also, this book will contain conservative treatment methods for patients suffering from diverse complications. There will be plentiful clinical cases including endoscopic findings, radiologic images, pathology and treatment outcome in this book. For these reasons, this book will give very valuable information to many gastroenterologists, oncologists , surgeons and general physicians.

Precision medicine is the main emphasis in healthcare after recognizing the importance to integrate the clinical data with the molecular data of a specific disease. The term was first introduced in 2015 in which the Precision Medicine Initiative was initiated with the final aim to provide targeted therapy with high efficacy and less toxicity. Precision medicine plays an increasingly important in gastrointestinal cancers. Gastrointestinal cancers are divided into the upper (esophagus, stomach) and lower part (hepatobiliary and colon) of the gastrointestinal system. We would like to explore the latest era of integrative therapeutic target in gastrointestinal cancers taking into consideration of various aetiologies including genetic and exposome (dietary factors, microbial, hormonal, environmental insults) and their interactions with the host microenvironment.

Principles of Immunotherapy in Breast and Gastrointestinal Cancers: Activity, Mechanisms of Resistance and New Sensitization Strategies presents updated research findings on immunotherapy, with special focus on the mechanisms of resistance of those cancer types and how to overcome them. The book discusses topics such as tumor cell-intrinsic and extrinsic mechanisms of cancer resistance to immunotherapy; the role of currently available biomarkers; strategies to overcome therapeutic resistance; sensitizing agents for cancer resistance to cell mediated immunotherapy; and Immunotherapeutic approaches, mechanisms of resistance and sensitizing strategies in gastroesophageal and biliopancreatic tumors and colorectal cancer. It is a valuable resource for researchers, students and members of the biomedical and medical fields who want to learn more about resistance to immunotherapy and how to overcome it. - Presents relevant findings on immunotherapy for breast and GI cancer types in a synthetic and didactic way for easy consult - Describes resistance mechanisms of those cancer types and how to overcome them to improve immunotherapy outcomes - Encompasses several diagrams and figures to help readers get a clearer picture of the research findings and how they can be applied to the clinical setting