The book represents a paradigm shift from the traditional static model of investigation of oxidative biology to the dynamic model of vascular oxidative stress. The investigation of vascular biology and cardiovascular medicine is made possible by the use of tissue engineering, nanotechnology and stem cell research. This is the first textbook to target a wide readership from academia to industry and government agencies in the field of cardiovascular diseases.

The endothelium is an excellent example of where biology meets physics and engineering. It must convert mechanical forces into chemical signals to maintain homeostasis. It also controls the immune response, drug delivery through the vasculature, and cancer metastasis. Basic understanding of these processes is starting to emerge and the knowledge ga

Modern mechanobiology converges both engineering and medicine to address personalized medicine. This book is built on the previously well-received edition, Hemodynamics and Mechanobiology of Endothelium. The central theme is "omic" approaches to mechanosignal transduction underlying tissue development, injury, and repair. A cadre of investigators has contributed to the chapters, enriching the interface between mechanobiology and precision medicine for personalized diagnosis and intervention. The book begins with the fundamental basis of vascular disease in response to hemodynamic shear stress and then details cardiovascular development and regeneration, valvular and cardiac morphogenesis, mechanosensitive microRNA and histone unfolding, computational fluid dynamics, and light-sheet imaging. This edition represents a paradigm shift from traditional biomechanics and signal transduction to transgenic models, including novel zebrafish and chick embryos, and targets a wider readership from academia to industry and government agencies in the field of mechanobiology.

Mechanobiology—the study of the effects of mechanics on biological events—has evolved to answer numerous research questions. Mechanobiology Handbook 2nd Edition is a reference book for engineers, scientists, and clinicians who are interested in mechanobiology and a textbook for senior undergraduate to graduate level students of this growing field. Readers will gain a comprehensive review of recent research findings as well as elementary chapters on solid mechanics, fluid mechanics, and molecular analysis techniques. The new edition presents, in addition to the chapters of the first edition, homework problem sets that are available online and reviews of research in uncovered areas. Moreover, the new edition includes chapters on statistical analysis, design of experiments and optical imaging. The editors of this book are researchers and educators in mechanobiology. They realized a need for a single volume to assist course instructors as a guide for didactic teaching of mechanobiology to a diverse student body. A mechanobiology course is frequently made up of both undergraduate and graduate students pursuing degrees in engineering, biology, or integrated engineering and biology. Their goal was to present both the elementary and cutting-edge aspects of mechanobiology in a manner that is accessible to students from many different academic levels and from various disciplinary backgrounds. Moreover, it is their hope that the readers of Mechanobiology Handbook 2nd Edition will find study questions at the end of each chapter useful for long-term learning and further discussion. Comprehensive collection of reviews of recent research Introductory materials in mechanics, biology, and statistics Discussion of pioneering and emerging mechanobiology concepts Presentation of cutting-edge mechanobiology research findings across various fields and organ systems End of chapter study questions, available online Considering the complexity of the mechanics and the biology of the human body, most of the world of mechanobiology remains to be studied. Since the field is still developing, the Mechanobiology Handbook raises many different viewpoints and approaches with the intention of stimulating further research endeavours.

Since publication of the First Edition in 1982, Hemostasis and Thrombosis has established itself as the pre-eminent book in the field of coagulation disorders. No other book is as inclusive in scope, with coverage of the field from the standpoint of both basic scientists and clinicians. This comprehensive resource details the essentials of bleeding and thrombotic disorders and the management of patients with these and related problems, and delivers the most up-to-date information on normal biochemistry and function of platelets or endothelial cells, as well as in-depth discussions of the pharmacology of anticoagulant, fibrinolytic, and hemostatic drugs. NEW to the Sixth Edition... • A new team of editors, each a leader in his field, assures you of fresh, authoritative perspectives. • Full color throughout • A companion website that offers full text online and an image bank. • A new introductory section of chapters on basic sciences as related to the field • Entirely new section on Hemostatic and Thrombotic Disorders Associated with Systemic Conditions includes material on pediatric patients, women's health issues, cancer, sickle cell disease, and other groups. • Overview chapters preceding each section address broad topics of general importance. This is the tablet version which does not include access to the supplemental content mentioned in the text.

Mechanobiology: From Molecular Sensing to Disease will provide a review of the current state of understanding of mechanobiology and its role in health and disease. It covers: Current understanding of the main molecular pathways by which cells sense and respond to mechanical stimuli, A review of diseases that with known or purported mechanobiological underpinnings; The role of mechanobiology in tissue engineering and regenerative medicine; Experimental methods to capture mechanobiological phenomena; Computational models in mechanobiology. - Presents our current understanding of the main molecular pathways by which cells sense and respond to mechanical stimuli - Provides a review of diseases with known or purported mechanobiological underpinnings - Includes the role of mechanobiology in tissue engineering and regenerative medicine - Covers experimental methods to capture mechanobiological phenomena

The Science, Etiology and Mechanobiology of Diabetes and Its Complications presents the most comprehensive synthesis of contemporary global research on diabetes, covering a novel and unique mechanobiological perspective – addressing prevention, management and treatment of tissue, organ and body system damage associated with diabetes and its complications. The book provides a unique approach to communicating diabetes-associated symptoms and opens avenues for development of novel therapeutic and preventive methods. It offers descriptive pathophysiology of diabetes and its complications with great emphasis on mechanobiology. Content coverage also includes management of tissue, organ and body system damage caused by chronic hyperglycemia. Biologists, life scientists, physicians, pharmacists, biomedical engineers, medical physicists, biomathematicians and computer scientists who are interested in the state-of-science and current challenges in the mechanobiology of diabetes should find this book very useful. Likewise, medical researchers in fields such as endocrinology, cardiovascular medicine, oncology, obesity, the immune system, inflammation and wound care and others who wish to be updated about the latest achievements in this exciting arena of research will find that information here. - Covers the state-of-knowledge in diabetes research from a mechanobiological perspective, including cell death and (neural, connective, adipose, vascular, renal etc.) tissue damage cascades and healing processes - Describes state-of-the-art technology in prevention, diagnosis, prognosis and treatment of tissue, organ and body system damage caused by chronic hyperglycemia and diabetes - Explores emerging research directions and future technology trends in the field of diabetes prevention and care, including common complications of diabetes (foot ulcers and amputation, peripheral neuropathy, retinal damage, renal damage, vascular and cardiac damage, connective tissue damage etc.) at the early stage of research and development in academia and industry

This invaluable book provides the first description of the diverse and fascinating functions of heme in life processes for a broad audience. It begins with an introduction of the intricate chemical properties of heme and the history of early observations of human diseases associated with heme. It then proceeds to describe the versatile roles of heme in controlling diverse molecular and cellular processes germane to human life and disease processes. In the second edition, a new chapter is devoted to describe findings about heme uptake, transport, and trafficking of heme synthesis intermediates in mammals. Additionally, a chapter about the newly discovered roles of elevated heme biosynthesis and uptake in lung tumorigenesis is included.Heme Biology is unified and logical in presentation. It is well suited for students and professionals in life sciences who wish to know about the fascinating biology of heme and its usefulness in health and diseases. It may also be used as a reference book for advanced readers and researchers who are interested in heme biology. The explanations in the book are detailed enough to capture the interest of the curious reader, and complete enough to provide the necessary information for researchers to have an in-depth molecular understanding of heme biology and further their studies in this fascinating realm.