This timely volume addresses the intimate pathophysiologic relationship between hypertension and cardiovascular disease. Hypertension is one of the most important global public health challenges, and its relationship to stroke and other catastrophic cerebrovascular diseases is an area of growing understanding. In this outstanding book, the editors and authors clearly and concisely synthesize our developing knowledge and place epidemiologic and physiologic information into a practical clinical context. Comprehensive chapters present the evidence supporting strategies for stroke prevention and care, including blood pressure lowering therapies, anti-coagulation, and management of other cerebrovascular risk factors. In addition to prescriptive measures for first stroke prevention, the book illuminates current regimens for care immediately after acute stroke and for the prevention of recurrent stroke. A unique section is dedicated to the exploration of the interaction between elevated blood pressure and brain function and cognition. The concluding chapter provides a resource towards optimizing the organization of stroke care. Hypertension and Stroke is of great utility for specialists in neurology and cardiovascular medicine and a valuable practical resource for all physicians caring for older adults and hypertensive patients.

The treatment of hypertension is now evolving into a decision-making process of ever greater complexity. Not only has the range of drugs available increased but so too has our knowledge of the diversity of individual patients' responsiveness to therapy, and the need to tailor their treatment with reference to a wide variety of additional factors. In order to provide effective patient care, the clinician needs to be aware of all the options available, but also of the evidence supporting their use and the extent to which that evidence justifies the choices made. In this new volume, leading authorities in their fields draw on the available evidence to provide answers to a series of key clinical questions facing the clinician treating hypertension: Should we treat prehypertension? How does the choice of therapy change in the presence of comorbidities such as obesity, ischemic heart disease, left ventricular hypertrophy, diabetes or cerebrovascular disease? Evidence-based Management of Hypertension provides answers to these and many other questions, as the authors present an expert analysis of the available evidence and offer authoritative recommendations for treatment planning. In each chapter, tables highlight evidence from a variety of sources, and every chapter concludes with a series of key practice points that present a summary of evidence-based recommendations for best practice, graded according to the quality of that evidence. For any clinician concerned with the care of the hypertensive patient, this volume will be a valuable aid to treatment planning and long-term management.

Risk Factors for Cerebrovascular Disease and Stroke address the relationship of a wide variety of vascular risk factors in the spectrum of cerebrovascular diseases. An international group of professionals the forefront of research and education, provide their expertise about environmental and genetic determinants for cerebrovascular disease and stroke. The authors aim to provide information on developments of genetic, environmental and lifestyle-related risk factors of various subtypes of stroke, and MRI-markers of cerebrovascular disease. One in two men, and one in three women after the age of 40, will develop a stroke in their lifetime. The burden of cerebrovascular disease extends far beyond that of acute clinical events such as stroke, with "covert" vascular injury on brain MRI being highly prevalent in older community-dwelling persons. Therefore, improving our understanding of the risk factors for stroke and cerebrovascular disease is of paramount importance for improving prevention strategies. Secular trends in stroke epidemiology, risk factors, and intermediate markers (including carotid ultrasound, brain MRI and circulating biomarkers) are presented. Cutting edge information on genetic, environmental and lifestyle-related risk factors of various subtypes of stroke and MRI-markers of cerebrovascular diseases are displayed. This important book is an essential reference to physicians interested in more effective primary prevention of stroke.

This book mainly discusses the current status of stroke transnational research and allows the reader to understand the interplay of common comorbidities in the stroke population such as diabetes and hypertension, and provides insight into stroke targets to promote cell survival, angiogenesis, neurogenesis, and most importantly, functional recovery after stroke. Throughout the world, stroke is still a leading cause of mortality and morbidity; each year approximately 15 million people worldwide suffer from stroke. Stroke is now the leading cause of death and disability in China. Large communities of stroke survivors are eagerly awaiting scientific advances in transnational stroke research that would offer neuroprotective therapeutics for acute stroke management, or rehabilitation and regenerative strategies utilizing novel stem cell-based approaches. While research is ongoing, the Editors have compiled this volume to help the further understanding of the pathophysiology of stroke and to review and identify future potential biomarkers. The book is written for students, researchers and physicians in neurosciences, neurology and neuroradiology.

This book is a unique source of practical information for frontline providers of care for stroke patients. It focuses on patient management—from stroke prevention through acute stroke management, through chronic care—and offers how-to guidance on implementing diagnostic and treatment protocols. Each chapter includes a bulleted list of key learning points; an evidence-based rationale for why the diagnostic and treatment recommendations work; a step-by-step approach to clinical application; practical recommendations from the authors; a critical pathway; and a bibliography. An entire chapter focuses on building a stroke team. Appendices include reproducible samples of order sets and a list of important medications.

This volume provides a comprehensive guide to the manifestations and pathogenesis involved with stroke, including advancements in research and a newfound understanding of the biochemical background of this cerebrovascular disorder. This intensive handbook is meant to give clinicians a source reference that will enable them to gain a thorough knowledge and understanding of the clinical features and management of the many neurological manifestations of stroke disorder. In addition, practitioners, clinicians, and researchers will gain a better understanding of highly studied topics, including amongst others, the medical complications associated with stroke, chapters on anterior circulation and hemorrhagic stroke syndromes, stroke related psychiatric disorders, and other rare causes of stroke disorder.

Stroke is a major global health problem because of its large contribution to mortality, morbidity, and disability. The most common form of stroke is ischemic stroke which accounts for approximately 80% of all strokes. During the past decade, our knowledge of the molecular and cellular processes that contribute to stroke pathophysiology has increased substantially and offers many targets for future therapeutic strategies. This book provides an overview of the current knowledge of stroke pathophysiology and the mechanisms that interfere with recovery and regeneration. Moreover, this book reviews the latest advances in the development of future therapeutic strategies.

Authored by the world's foremost stroke experts, this classic text brings you fully up to date with current research findings and management approaches for cerebrovascular disease. Stroke: Pathophysiology, Diagnosis, and Management, 7th Edition, covers every aspect of this fast-moving field, and is an ideal resource for stroke specialists, general neurologists, and other medical professionals with an interest in stroke. You'll find expert clinical guidance, comprehensive pathophysiology coverage, data from recent trials, advances in diagnostic tests, full-color CT images, pathology slides, and much more, for a complete picture of today's stroke medicine. - Helps you recognize the clinical manifestations of stroke, use the latest laboratory and imaging studies to arrive at a diagnosis, and generate an effective medical and surgical treatment plan. - Keeps you abreast of the overwhelming volume of studies and guidelines in this dynamic field, providing clear summaries and practical evaluations of all relevant data. - Contains updates throughout, including the latest clinical trials (thrombectomy, DAWN, DEFUSE), genetics research, prevention research, new therapies, and the new guidelines from the ASA. - Includes new slides for lectures, covering basic science, case studies, and interventional treatment overviews. - Features a Key Points summary at the beginning of each chapter so you can quickly find important information. - Provides abundant full-color CT images and pathology slides that help you make efficient and accurate diagnoses.