Dementia is a massive and increasing global problem, with the current prevalence anticipated to double every 20 years as people live longer. Neuroimaging in dementia is recommended by most clinical guidelines and its role has traditionally been to exclude a mass lesion, rather than to support a specific diagnosis. All radiologists will be aware of a steady rise in the number of requests for brain imaging in old people, but what can imaging reliably tell us and what kind of imaging should we use? In affluent societies we now have a range of structural and molecular brain imaging techniques at our disposal, with specific ligands and sophisticated image analysis techniques now available for clinical use. However, we have difficulty justifying which patients to scan, using which modality and when. We know that Alzheimer’s disease is the most common neuropathology contributing to a diagnosis of Alzheimer’s disease but we also know from large post-mortem studies that most brain pathology in those who have died with a diagnosis of dementia is mixed. Thus understanding different diseases that can cause dementia, how these co-exist or interact and appreciating that not all dementia is Alzheimer’s disease is important. Equally important is awareness of individual differences in response to a neuropathological burden and what factors provide resilience against dementia that might be maximized to reduce or postpone its impact. This issue draws together contributions from experts in their fields to provide clarity to the topic in a comprehensive collection of articles.

Information for neuroimaging specialists includes a "Diagnostic Checklist or “Clinical Recommendations along with tables presenting recommended MR sequences and protocols. The primary focus of the issue is 3.0T; one article specifically deals with 7T and higher fields are mentioned sporadically throughout. Topics include: Tumor High-Field MR; Stroke High-Field MR; High-Field MR of Inflammation; Vascular Disorders: MR Angiography of Brain Vessels, MR Angiography of Neck Vessels, and Perfusion Imaging; Plaque Imaging; Neurodegenerative Disease; Epilepsy Imaging; Head and Neck Oncology Applications; Pediatric High-Field Imaging; Spine High-Field Imaging; Ultra High-Field Imaging; Future Perspectives on High-Field MR

An especially important issue during these uncertain times, this collection of articles examines Neuroimaging from an economic perspective, with articles that discuss leadership, “turf battles , strategic planning in the face of declining reimbursement, and the impact of teleradiology and telemedicine in cutting costs and improving access. Medicolegal issues are addressed, as is evidence-based medicine and effective utilization. Performance measures and conflict of interest are reviewed, among many other topics.

This issue of Medical Clinics covers the important advances surrounding the early intervention of Alzheimer's Disease. Guest edited by world-renowned experts from around the world, the topics covered will include evaluation of new diagnostic criteria, CSF biomarkers, diagnostic imaging, neurocognitive approaches, breaking clinical trials and more.

This issue of MRI Clinics focuses on Advances in Diffusion-weighted Imaging and is edited by Dr. Kei Yamada. Articles will include: Technical Basics of Diffusion-weighted Imaging; Neurofluid as Assessed by Diffusion-weighted Imaging; Diffusion-weighted Imaging is the Key to Diagnoses; Diffusion-weighted Imaging of the Spinal Cord; Intracranial Abnormalities with Diffusion Restriction; Brain Anatomy by Diffusion-weighted Imaging; Measuring Perfusion: Intravoxel Incoherent Motion; Temperature Measurement by Diffusion-weighted Imaging; Diffusion-weighted Imaging at Ultra-high Field MRI; Diffusion-weighted Imaging for Radiomics; Diffusion Weighted Imaging for Infants; Diffusion-weighted Imaging of the Head and Neck (Including Temporal Bone); DTI, DKI and Q-space Imaging; and more!

This issue of Neuroimaging Clinics of North America focuses on Magnetoencephalography (MEG), and is edited by Drs. Roland Lee and Mingxiong Huang. Articles will include: MEG signal processing, forward modeling, MEG inverse source imaging, and Coherence analysis; Magnetoencephalography for pre-surgical functional mapping; Magnetoencephalography for mild TBI and PTSD; Magnetoencephalography for autism; Magnetoencephalography for schizophrenia; Magnetoencephalography for Alzheimer's disease; Pediatric Magnetoencephalography; The MEG Measurement Techniques; MEG and Language/Linguistics; MEG for Epilepsy; Integration of MEG results into the patient workup – Merging multiple modalities; and more!

In this issue of Neuroimaging Clinics, guest editors Drs. Pejman Jabehdar Maralani and Sean Symons bring their considerable expertise to the topic of Neurotrauma. Top experts in the field cover key topics such as conventional MRI in trauma management in adults and children; imaging approach to concussion; clinical updates on concussion; the current state of DWI/DTI for trauma prognostication; the current state of fMRI/rs-fMRI for trauma prognostication; and more. - Contains 13 relevant, practice-oriented topics including MRI perfusion in traumatic brain injury; traumatic brain injury and vision; traumatic brain injury and cerebrovascular reactivity; SWI / qSM in traumatic brain injury; imaging of non-accidental trauma in children; advances in MRI related to TBI management; and more. - Provides in-depth clinical reviews on neurotrauma, offering actionable insights for clinical practice. - Presents the latest information on this timely, focused topic under the leadership of experienced editors in the field. Authors synthesize and distill the latest research and practice guidelines to create clinically significant, topic-based reviews.

This issue discusses the newest approaches to PET/CT Imaging. The roles of PET/CT in pulmonary masses, GI malignancies, head and neck cancer, lymphoma, soft tissue sarcoma, pancreatic and biliary tree malignancies, malignant melanoma, breast carcinoma, common pediatric malignancies, bone malignancies, and the role PET/CT plays in radiation oncology treatment planning are reviewed.

This book describes the latest modalities such as tau PET imaging for diagnosis of Alzheimer’s disease and other dementias, and also provides information on handling and analyzing imaging data that is not found in other books. In addition, it introduces routine imaging studies in the management of dementia in Japan. The prevalence of dementia has increased over the past few decades, either because of greater awareness and more accurate diagnosis, or because increased longevity has created a larger population of the elderly, the age group most commonly affected. Although only clinical assessment can lead to a diagnosis of dementia, neuroimaging in dementia is recommended by most clinical guidelines, and its adjunct role has traditionally been to exclude a mass lesion rather than to support a specific diagnosis. Neuroimaging may be also helpful for developing new strategies to achieve diagnoses as early as possible for therapies aimed at slowing the progression of neurodegenerative diseases manifesting dementia. Under these conditions, all clinicians and researchers who are involved in neuroimaging for dementia should decide which patients to scan, when imaging patients is most useful, which modality to use, how to handle imaging data from many institutions, and which analytical tool to use. This edition comprises contributions from leading Japanese experts in their fields.

PET imaging has shown its value in diagnosing diseases affecting older people. Most significantly this has been with regard to the diagnosis of Alzheimer’s disease and other forms of dementia. Parkinson’s disease is another condition in which PET has proved valuable. This issue also included articles on the uses of PET for diagnosing cerebrovascular disease and for assessing neuroplasticity.