This book sheds light on a little-known aspect of the Imperial family of Japan: For three generations, members of the family have devoted themselves to biological research. Emperor Showa (Hirohito) was an expert on hydrozoans and slime molds. His son, Emperor Akihito, is an ichthyologist specializing in gobioid fishes, and his research is highly respected in the field. Prince Akishino, Emperor Akihito’s son, is known for his research on giant catfish and the domestication of fowl, while Prince Hitachi, Emperor Akihito’s brother, has conducted research on cancer in animals. The book shows how they became interested in biology, how seriously they were committed to their research, what their main scientific contributions are, and how their achievements are valued by experts at home and abroad. To commemorate the 60-year reign of Emperor Showa and his longtime devotion to biology, the International Prize for Biology was founded in 1985. The prize seeks to recognize and encourage researches in basic biology. A list of winners and a summary of their research are presented in the last part of the book. The author, an eminent biologist who has given lectures to the Imperial Family, explains their research and tells the fascinating story of biology and the Imperial Family of Japan. The book is a valuable resource, not only for biology students and researchers, but also for historians and anyone interested in science and the Royal and Imperial families.

Synthetic Biology — A Primer (Revised Edition) presents an updated overview of the field of synthetic biology and the foundational concepts on which it is built. This revised edition includes new literature references, working and updated URL links, plus some new figures and text where progress in the field has been made.The book introduces readers to fundamental concepts in molecular biology and engineering and then explores the two major themes for synthetic biology, namely 'bottom-up' and 'top-down' engineering approaches. 'Top-down' engineering uses a conceptual framework of systematic design and engineering principles focused around the Design-Build-Test cycle and mathematical modelling. The 'bottom-up' approach involves the design and building of synthetic protocells using basic chemical and biochemical building blocks from scratch exploring the fundamental basis of living systems.Examples of cutting-edge applications designed using synthetic biology principles are presented, including: The book also describes the Internationally Genetically Engineered Machine (iGEM) competition, which brings together students and young researchers from around the world to carry out summer projects in synthetic biology. Finally, the primer includes a chapter on the ethical, legal and societal issues surrounding synthetic biology, illustrating the integration of social sciences into synthetic biology research.Final year undergraduates, postgraduates and established researchers interested in learning about the interdisciplinary field of synthetic biology will benefit from this up-to-date primer on synthetic biology.

One of the key features of biological systems is complexity, where the behavior of high level structures is more than the sum of the direct interactions between single components. Synthetic Biologists aim to use rational design to build new systems that do not already exist in nature and that exhibit useful biological functions with different levels of complexity. One such case is metabolic engineering, where, with the advent of genetic and protein engineering, by supplying cells with chemically synthesized non-natural amino acids and sugars as new building blocks, it is now becoming feasible to introduce novel physical and chemical functions and properties into biological entities. The rules of how complex behaviors arise, however, are not yet well understood. For instance, instead of considering cells as inert chassis in which synthetic devices could be easily operated to impart new functions, the presence of these systems may impact cell physiology with reported effects on transcription, translation, metabolic fitness and optimal resource allocation. The result of these changes in the chassis may be failure of the synthetic device, unexpected or reduced device behavior, or perhaps a more permissive environment in which the synthetic device is allowed to function. While new efforts have already been made to increase standardization and characterization of biological components in order to have well known parts as building blocks for the construction of more complex devices, also new strategies are emerging to better understand the biological dynamics underlying the phenomena we observe. For example, it has been shown that the features of single biological components [i.e. promoter strength, ribosome binding affinity, etc] change depending on the context where the sequences are allocated. Thus, new technical approaches have been adopted to preserve single components activity, as genomic insulation or the utilization of prediction algorithms able to take biological context into account. There have been noteworthy advances for synthetic biology in clinical technologies, biofuel production, and pharmaceuticals production; also, metabolic engineering combined with microbial selection/adaptation and fermentation processes allowed to make remarkable progress towards bio-products formation such as bioethanol, succinate, malate and, more interestingly, heterologous products or even non-natural metabolites. However, despite the many progresses, it is still clear that ad hoc trial and error predominates over purely bottom-up, rational design approaches in the synthetic biology community. In this scenario, modelling approaches are often used as a descriptive tool rather than for the prediction of complex behaviors. The initial confidence on a pure reductionist approach to the biological world has left space to a new and deeper investigation of the complexity of biological processes to gain new insights and broaden the categories of synthetic biology. In this Research Topic we host contributions that explore and address two areas of Synthetic Biology at the intersection between rational design and natural complexity: (1) the impact of synthetic devices on the host cell, or "chassis" and (2) the impact of context on the synthetic devices. Particular attention will be given to the application of these principles to the rewiring of cell metabolism in a bottom-up fashion to produce non-natural metabolites or chemicals that should eventually serve as a substitute for petrol-derived chemicals, and, on a long-term view, to provide economical, ecological and ethical solutions to today’s energetic and societal challenges.

As a transnational history of science, Japan's Empire of Birds: Aristocrats, Anglo-Americans, and Transwar Ornithology focuses on the political aspects of highly mobile Japanese explorer-scientists, or cosmopolitan gentlemen of science, circulating between Japanese and British/American spaces in the transwar period from the 1920s to 1950s. Annika A. Culver examines a network of zoologists united by their practice of ornithology and aristocratic status. She goes on to explore issues of masculinity and race related to this amidst the backdrop of imperial Japan's interwar period of peaceful internationalism, the rise of fascism, the Japanese takeover of Manchuria, and war in China and the Pacific. Culver concludes by investigating how these scientists repurposed their aims during Japan's Allied Occupation and the Cold War. Inspired by geographer Doreen Massey, themes covered in the volume include social space and place in these specific locations and how identities transform to garner social capital and scientific credibility in transnational associations and travel for non-white scientists.

A 2023 Choice Reviews Outstanding Academic Title Reading Darwin in Imperial Russia: Literature and Ideas expands upon the cataloging efforts of earlier scholarship on Darwin’s reception in Russia to analyze the rich cultural context and vital historical background of writings inspired by the arrival of Darwin’s ideas in Russia. Starting with the first Russian translation of The Origin of Species in 1864, educated Russians eagerly read Darwin’s works and reacted in a variety of ways. From enthusiasm to skepticism to hostility, these reactions manifested in a variety of published works, starting with the translations themselves, as well as critical reviews, opinion journalism, literary fiction, and polemical prose. The reception of Darwin spanned reverent, didactic, ironic, and sarcastic modes of interpretation. This book examines some of the best-known authors of the second half of the nineteenth century (Dostoevsky, Chernyshevsky, Chekhov) and others less well-known or nearly forgotten (Danilevsky, Timiriazev, Markevich, Strakhov) to explore the multi-faceted impact of Darwin’s ideas on Russian educated society. While elements of Darwin’s Russian reception were comparable to other countries, each author reveals distinctly Russian concerns tied to the meaning and consequences of the challenge posed by Darwinism. The scholars in this volume demonstrate not only what the authors wrote, but why they took their unique perspectives.

In the 1950s biologists became alarmed by the plight of Africa’s wildlife. Since then they have sought to arrest its decline, but increasing competition between wild fauna and expanding human populations shows that protection alone has been inadequate. The conservationists’ position and strategies have been progressively eroded: large-scale game cropping schemes have failed to produce expected revenues, the consequences of the tourist industry have been unexpectedly detrimental, and educational programs have rarely convinced rural Africans to conserve resources. Dr. Marks argues that the management and conservation of wild animals in Third World countries must include cultural as well as biological dimensions and that changes in human social systems will be necessary to sustain wildlife and the environmental processes. He describes indigenous attempts to manage wildlife and suggests new research initiatives that would lead to wildlife policies more in keeping with human development needs and with the realities of the rural countryside.

"This timely book reveals how the increase in traffic of transpacific plants, insects, and peoples raised fears of a "biological yellow peril" beginning in the late nineteenth century, when mass quantities of nursery stock and other agricultural products were shipped from large, corporate nurseries in Japan to meet the growing demand for exotics in the United States. Jeannie Shinozuka marshals extensive research to explain how the categories of "native" and "invasive" defined groups as bio-invasions that must be regulated-or somehow annihilated-during a period of American empire-building. Shinozuka shows how the modern fixation on foreign species provided a linguistic and conceptual arsenal for anti-immigration movements that gained ground in the early twentieth century. Xenophobia fed concerns about biodiversity, and in turn facilitated the implementation of plant quarantine measures while also valuing, and devaluing, certain species over others. The emergence and rise of economic entomology and plant pathology alongside public health and anti-immigration movements was not merely coincidental. Ultimately, what this book unearths is that the inhumane and unjust incarceration of Japanese Americans during World War II cannot, and should not, be disentangled from this longer history"--

The purpose of this two-volume work is to provide an update on the use of this powerful technology. As such, the books provide an insight in to the techniques for the non-specialist. Scientists embarking upon st udies in chronic lung disease will find a review of the current status of research. At the same time, the books are useful to clinicians, bo th specialist and academic, and to scientists already involved in the basic aspects of the pathogenesis of lung disease. Both volumes deal w ith basic mechanisms of cell biology, receptors and cellactivation and provide an insight as to how the technology influences our concepts o f pathogenesis and viceversa.