With the publications of the International subarachnoid aneurysm trial (ISAT), endovascular treatment has become one of the most important treatments of intracranial aneurysms, and was used more and more in clinic settings. However, intracranial complex aneurysms (such as giant aneurysms, wide-necked aneurysms, fusiform aneurysms and dissecting aneurysms) still impose a huge challenge for clinicians. Flow diverter (FD) is a novel device for the treatment of aneurysms based on the understanding of hemodynamic mechanism of aneurysm occlusion. It could divert the blood flow from the aneurysm neck, and promote aneurysm occlusion without inserting coils into the aneurysms. In addition, the FDs had the advantage of simplifying the procedure and relieving the mass effect.

This Research Topic aims to collect all the Case Reports submitted to the Endovascular and Interventional Neurology section. All the Case Reports submitted to this collection will be personally assessed by a senior Associate Editor before the beginning of the peer-review process. Please make sure your article adheres to the following guidelines before submitting it.Case Reports highlight unique cases of patients that present with an unexpected diagnosis, treatment outcome, or clinical course.

The World Stroke Organization reports that “stroke has already reached epidemic proportions. Globally1 in 4 adults over the age of 25 will have a stroke in their lifetime. 12.2 million people worldwide will have their first stroke this year, and 6.5 million will die as a result.” Ischemic strokes are the most common type of stroke, with about 87% of all strokes being ischemic strokes. This new volume addresses this epidemic by presenting detailed studies on ischemic injury, with emphasis on the molecular-level mechanisms and the role of signaling pathways in the body, their structure, and their mechanism of action. The book focuses on molecular pharmacology plans and explains the new areas of research on the discovery of therapeutic molecules that can be used for combating this life-threatening disease. The authors discuss stroke occurrence at different stages of life as well as sex-based differences in its treatment. They cover aspects of the clinical treatment and diagnosis of patients with cardiovascular events, including in-depth information on the prevention, evaluation, therapy selection, result projection, and long-term course of the disease in affected patients. They also detail the involvement of platelets, neurotransmitters, renin-angiotensin-aldosterone system, and vitamin D in ischemic injury.

Fundamentals of Paramedic Practice An indispensable guide for aspiring paramedics and emergency medical professionals Paramedic practice is swiftly evolving, driven by changes in the paramedic curriculum. To meet the growing demands of the community, student paramedics and clinicians working in out-of-hospital care must stay abreast of this rapid evolution. Fundamentals of Paramedic Practice, Third Edition contributes to driving the profession forward and provides a comprehensive, accessible text authored by experienced paramedics and academics. This third edition has undergone comprehensive updates, introducing new chapters that provide students and recently registered practitioners with a vital overview of the theory and practice of contemporary paramedicine. This is an essential resource for the next generation of paramedics and out-of-hospital practitioners. Readers of the third edition of Fundamentals of Paramedic Practice will find: A multidisciplinary approach incorporating varied and dynamic research New chapters on subjects including end of life care, domestic violence, and paramedic wellbeing Learning activities to aid understanding and retention Fundamentals of Paramedic Practice, Third Edition is ideal for undergraduate paramedic and emergency care students, as well as registered paramedics, clinicians, and educators.