ntegrative Pharmacology can be used to determine the multi-pharmacological effects of traditional medicines such as traditional Chinese medicine (TCM), Kampo, Sa-sang, Ayurveda, etc.). Through qualitative and quantitative pharmacokinetic-pharmacodynamic (PK-PD) correlations among multi-constituents and multi-targets, integrating chemical profiling, ADME/PK processes, molecular network calculation and resulting experimental validation, the use of Integrative Pharmacology has become widespread. The data has provided a novel paradigm to evaluate the druggability of bioactive ingredients of herbs or formulae, to decipher the pharmacological mechanisms of drug action and to screen potentially new indications for approved drugs and previously unidentified adverse events. On this basis, Integrative Pharmacology may offer an effective way to test the potential scientific basis for traditional medicines and to assess what roles of traditional medicine can and cannot play in pharmaceuticals.

A concise overview of some of the findings and topics related to the pharmacology and clinical applications of traditional herbal therapeutics. It addresses the current and potential roles for herbal medicine in the context of our evolving health-care systems. Introducing many pharmacological advances made, the work also describes the modern theories and scientific methodologies applied to today's studies on herbal medicines and new drug development.

Metabolic diseases such as type 2 diabetes mellitus (T2DM), obesity, non-alcoholic fatty liver disease (NAFLD), and cancer are among the most prevalent health problems worldwide. These diseases are characterized by altered metabolism and impaired energy homeostasis, leading to the development of chronic diseases. Medicines derived from plants and fungi including herbal extracts and isolated compounds, have been used for centuries to treat various ailments and have recently gained renewed attention as potential therapeutics for metabolic diseases. Pharmacological approaches are essential for developing such preparations to treat these diseases. Computational approaches can generate early-stage hypotheses about potential targets and mechanisms and can be one basis for assessing the pharmacological activity of an extract or a metabolite. Understanding the molecular mechanisms underlying metabolic diseases and the potential benefits of herbal medicines (incl. herbal medical products) can provide valuable insights into new therapeutic targets and treatment options.

The multidisciplinary applications of natural science in drug discovery are essential for identifying and developing new drugs and represent a promising area of research. Drug discovery is a complex and challenging process that involves multiple disciplines, including biology, chemistry, pharmacology, and medicine. One of the most interesting areas of drug discovery is using natural science, which involves the study of natural products and their potential therapeutic benefits, in which the research literature has previously been lacking appropriate attention. Multidisciplinary Applications of Natural Science for Drug Discovery and Integrative Medicine is a research book that bridges the gap between traditional and natural science approaches to identify new drug molecules in treating various diseases. The book focuses on allopathic and complementary medicine. It takes a cross-disciplinary examination of biology, chemistry, pharmacology, mathematics, physics, and medicine. This book is suitable for researchers, post-doctoral fellows, graduate students, and post-graduate students interested in exploring natural science's multidisciplinary applications in drug discovery and integrative medicine.

**Selected for Doody's Core Titles® 2024 in Complementary & Integrative Health** Get a solid, global foundation of the therapies and evidence-based clinical applications of CAI. Fundamentals of Complementary, Alternative, and Integrative Medicine, 6th Edition is filled with the most up-to-date information on scientific theory and research of holistic medicine from experts around the world. The 6th edition of this acclaimed text includes all new content on quantum biology and biofields in health and nursing, integrative mental health care, and homeopathic medicine. Its wide range of topics explores therapies most commonly seen in the U.S., such as energy medicine, mind-body therapies, and reflexology along with traditional medicine and practices from around the world. With detailed coverage of historic and contemporary applications, this text is a solid resource for all practitioners in the medical, health, and science fields! - Coverage of CAI therapies and systems includes those most commonly encountered or growing in popularity, so you can carefully evaluate each treatment. - An evidence-based approach focuses on treatments best supported by clinical trials and scientific evidence. - Observations from mechanisms of action to evidence of clinical efficacy answers questions of how, why, and when CAM therapies work. - A unique synthesis of information, including historical usage, cultural and social analysis, current basic science theory and research, and a wide range of clinical investigations and observations, makes this text a focused, authoritative resource. - Global coverage includes discussions of traditional healing arts from Europe, Asia, Africa, and the Americas. - Clinical guides for selecting therapies, and new advances for matching the appropriate therapy to the individual patient, enables you to offer and/or recommend individualized patient care. - Expert contributors include well-known writers such as Kevin Ergil, Patch Adams, Joseph Pizzorno, and Marc Micozzi. - A unique history of CAI traces CAM therapies from their beginnings to present day practices. - Suggested readings and references on the companion website list the best resources for further research and study.

This eBook is a collection of articles from a Frontiers Research Topic. Frontiers Research Topics are very popular trademarks of the Frontiers Journals Series: they are collections of at least ten articles, all centered on a particular subject. With their unique mix of varied contributions from Original Research to Review Articles, Frontiers Research Topics unify the most influential researchers, the latest key findings and historical advances in a hot research area! Find out more on how to host your own Frontiers Research Topic or contribute to one as an author by contacting the Frontiers Editorial Office: frontiersin.org/about/contact.

This eBook is a collection of articles from a Frontiers Research Topic. Frontiers Research Topics are very popular trademarks of the Frontiers Journals Series: they are collections of at least ten articles, all centered on a particular subject. With their unique mix of varied contributions from Original Research to Review Articles, Frontiers Research Topics unify the most influential researchers, the latest key findings and historical advances in a hot research area! Find out more on how to host your own Frontiers Research Topic or contribute to one as an author by contacting the Frontiers Editorial Office: frontiersin.org/about/contact.

Highlights the importance and benefit of mass spectrometry-based metabolomics for identifying biomarkers that accurately screen for potential biomarkers of diseases Mass spectrometry-based metabolomics offer new opportunities for biomarker discovery in complex diseases and may provide pathological understanding of diseases beyond traditional technologies. It is the systematic analysis of low-molecular-weight metabolites in biological samples and has been applied to discovering and identifying the perturbed pathways. Currently, mass spectrometry-based metabolomics has become an important tool in clinical research and the diagnosis of human disease. Mass Spectrometry-Based Metabolomics in Clinical and Herbal Medicines comprehensively presents the current state, challenges, and applications of high-throughput mass spectrometry-based metabolomics such as metabolites analysis, biomarker discovery, technical challenges, discovery of natural product, mechanism interpretation of action, discovery of active ingredients, clinical application and precision medicine, and enhancing their biomedical value in a real world of biomedicine, shedding light on the potential for spectrometry-based metabolomics. It highlights the value of mass spectrometry-based metabolomics and metabolism to address the complexity of herbal medicines in systems pharmacology, especially, to link phytochemical analysis with the assessment of pharmacological effect and therapeutic potential. Each chapter has been laid out with introduction, method, up-to-date literature, identification of biomarker, and applications Covers the current state, challenges, and applications of high-throughput mass spectrometry-based metabolomics in the discovery of biomarker, active ingredients, natural product, etc. Constitutes a unique and indispensable practical guide for any phytochemistry or related laboratory, and provides hands-on description of new techniques Provides a guide for new practitioners of pharmacologists, pharmacological scholars, drug developers, botanist, researchers of traditional medicines. Mass Spectrometry-Based Metabolomics in Clinical and Herbal Medicines provides a landmark of mass spectrometry-based metabolomics research and a beneficial guideline to graduate students and researchers in academia, industry, and technology transfer organizations in all biomedical science fields.

As the medicinal plant industry blooms into a billion dollar business, it reaches beyond collection, propagation, harvesting and sale of crude vegetal drugs into product formulation, packaging and dispensing of sophisticated phyto-pharmaceuticals and herbal preparations. The scientific study of these medicines and the systematic uplifting of the industry to preserve the ancient and serve the modern, is now a global challenge. The Medicinal Plant Industry puts together the various facets of this multi-disciplinary industry and its global interest. It discusses the dire need for developing countries to acquire technologies and techniques for programmed cultivation of medicinal plants. It addresses a wide variety of topics including the old philosophies, modern impact of traditional medicines, and methods of assessing the spontaneous flora for industrial utilization. It covers aspects of cultivation and climatic variations, biological assessment and formulation, process technologies, phytochemical research and information sources. The book reviews highly developed traditional medicine in China and India, and covers experiences in Africa and other continents.