Through an unprecedented multidisciplinary and global approach, this book documents the dramatic several-thousand-year history of leprosy using bioarchaeological, clinical, and historical information from a wide variety of contexts, dispelling many long-standing myths about the disease. Drawing on her 30 years of research on the infection, Charlotte Roberts begins by outlining its bacterial causes, how it spreads, and how it affects the body. She then considers its diagnosis and treatment, both historically and in the present. She also looks at the methods and tools used by paleopathologists to identify signs of leprosy in skeletons. Examining evidence in human remains from many countries, particularly in Europe and including Britain, Hungary, and Sweden, Roberts demonstrates that those affected were usually buried in the same cemeteries as others in their communities, contrary to the popular belief that they were all ostracized or isolated from society into leprosy hospitals. Other myths addressed by Roberts include the assumptions that leprosy can’t be cured, that leprosy is no longer a problem today, and that what is called “leprosy” in the Bible is the same illness as the disease with that name now. Roberts concludes by projecting the future of leprosy, arguing that researchers need to study the disease through an ethically grounded evolutionary perspective. Importantly, she advises against use of the word “leper” to avoid perpetuating stigma today surrounding people with the infection and resulting disabilities. Leprosy will stand as the authoritative source on the subject for years to come. A volume in the series Bioarchaeological Interpretations of the Human Past: Local, Regional, and Global Perspectives, edited by Clark Spencer Larsen

This book explains both the basic science and the applications of biotechnology-derived pharmaceuticals, with special emphasis on their clinical uses. The foundations of pharmaceutical biotechnology lie mainly in the capability of plants, microorganism, and animals to produce low and high molecular weight compounds useful as therapeutics. Pharmaceutical biotechnology has flourished since the advent of recombinant DNA technology and metabolic engineering, supported by the well-developed bioprocess technology. A large number of monoclonal antibodies and therapeutic proteins have been approved, delivering meaningful contributions to patients’ lives, and the techniques of biotechnology are also a driving force in modern drug discovery. Due to this rapid growth in the importance of biopharmaceuticals and the techniques of biotechnologies to modern medicine and the life sciences, the field of pharmaceutical biotechnology has become an increasingly important component in the education of pharmacists and pharmaceutical scientists. This book will serve as a complete one-stop source on the subject for undergraduate and graduate pharmacists, pharmaceutical science students, and pharmaceutical scientists in industry and academia.

First multi-year cumulation covers six years: 1965-70.

Issues for 1977-1979 include also Special List journals being indexed in cooperation with other institutions. Citations from these journals appear in other MEDLARS bibliographies and in MEDLING, but not in Index medicus.

Advances in Microbial Physiology

The Architecture and Landscape of Health explores buildings and landscapes that were designed to treat or prevent disease in the era before pharmaceuticals and biomedicine emerged as first line treatments. Written from an architectural perspective, it examines the historical relationship between health and place through the emergence of dedicated therapeutic building types from the late eighteenth to the early twentieth century, a time when the environment was viewed as integral to the health of both the individual and the population. This book provides an overview of ideas surrounding health and place and their impact on architecture and designed landscapes. Different therapeutic buildings and places are examined, including public parks, asylums, sanatoria, leprosaria, quarantine stations, public baths and healthy homes. Each chapter outlines the medical context, common therapies, a history of buildings designed in response to these, and an examination of how such places were perceived to have functioned. Illustrated using geographically and temporally diverse examples, the book includes designs drawn from locations across the world including Europe, the Americas, Africa, Australia and Asia. The Architecture and Landscape of Health identifies and examines moments in the conversation between health and design, and is a timely look back on the resultant buildings and places, offering insights which could inform the design of therapeutic places of the future. An ideal read for researchers, academics and upper-level postgraduate students interested in architecture, and architectural history, particularly relating to healthcare design and medical history.

Mycobacteria are bacterial pathogens which cause diseases in humans and non-human animals. This monograph will primarily cover the most important and widely researched groups of mycobacteria: members of the Mycobacterium tuberculosis complex (MTC) and Mycobacterium leprae, across a wide range of host species. M. tuberculosis and M. bovis are particularly relevant with the increasing drug resistance and co-infection with HIV associated with M. tuberculosis and the possible cross-infection of badgers and cattle associated with M. bovis. This book will provide a reference for researchers working in different fields creating a work which draws together information on different pathogens, and by considering the diseases in a zoonotic context provides a One Health approach to these important groups of diseases.