Jasper's Basic Mechanisms, Fourth Edition, is the newest most ambitious and now clinically relevant publishing project to build on the four-decade legacy of the Jasper's series. In keeping with the original goal of searching for "a better understanding of the epilepsies and rational methods of prevention and treatment.", the book represents an encyclopedic compendium neurobiological mechanisms of seizures, epileptogenesis, epilepsy genetics and comordid conditions. Of practical importance to the clinician, and new to this edition are disease mechanisms of genetic epilepsies and therapeutic approaches, ranging from novel antiepileptic drug targets to cell and gene therapies.

This volume is the first comprehensive text and clinical reference on idiopathic myoclonic epilepsies of infancy, childhood, adolescence, and adulthood. The world’s foremost experts describe the phenotypes and subtypes of myoclonic epilepsies and the underlying molecular defects and summarize cutting-edge advances in molecular genetics that shed new light on the etiologies of these syndromes. The book offers clinicians much-needed assistance in recognizing and diagnosing idiopathic myoclonic epilepsies and selecting appropriate treatment. Each chapter includes diagnostic and treatment algorithms to guide practitioners in clinical decision making.

This volume brings together current research on the idiopathic and symptomatic epilepsies from all relevant basic science and clinical disciplines and identities promising areas of future investigation. Coverage represents advancing areas of biology that are being applied to epilepsy research, including developmental neurobiology, molecular biology and genetics, cellular and systems neurosciences, neurochemical pharmacology, and brain imaging. The book is organized into sections on neural development, genes, and the epilepsies; the idiopathic epilepsies; symptomatic lesional epilepsies; and frontiers in brain imaging and therapeutics. An editors' introduction to each section provides an overview of the fields of biology covered.

s functional imaging becomes more crucial in discovering and understanding the neurological nuances that trigger seizures, one must be able to interpret the data that PET, SPECT and functional MRI scans collect. Functional Imaging in the Epilepsies, a top-notch text edited by international experts, thoroughly explains the use of these modalities to pinpoint where and why seizures occur

ritten by leading international authorities, this volume is the first reference to discuss neocortical epilepsies as a distinct subset of epilepsy syndromes. Coverage begins with in depth reviews of the functional anatomy and cognitive functions of the normal human neocortex. Subsequent chapters focus on the epileptic human neocortex and the classification and clinical characteristics of neocortical epilepsies. An extensive section examines the sophisticated neuroimaging studies and other techniques that are now used to localise and evaluate neocortical seizures. Other major sections discuss the use of standard and new drugs in treatment and describe current techniques for surgical treatment

his volume is an up-to-date, authoritative, and comprehensive examination of Parkinson's Disease and related disorders that primarily involve the basal ganglia. The discussions focus on the most recent advances in Parkinson's Disease research. Section topics include epidemiology and genetics, associated disorders, pathogenesis, and surgical treatment of Parkinson's Disease. This state-of-the-art review is based on presentations by leading international experts in the field at the XIIIth International Congress on Parkinson's Disease