This sixth edition provides an overview of fetal and neonatal pathology through a system-based approach. This book contains new chapters on immunology, with a continued focus on molecular aspects of pathology in the perinatal setting. The general principles of perinatal pathology and their clinical situations are also discussed, along with specific pathological entities and their organ systems. Keeling’s Fetal and Neonatal Pathology, sixth edition aims to help the reader treat common problems through anatomical pathology findings and is relevant to practicing and trainee pathologists, obstetricians, maternal and fetal medicine specialists, neonatologists, and pediatricians.

This revised and up-dated edition has a practical approach to the examination of both foetuses and perinatal deaths. It provides essential clinical and pathophysiological information and discusses the pathogenesis of abnormalities as a basis for appropriate methods of investigation. Part 1 deals with termination of pregnancy for foetal anomalies. Part 2 is organized by system, describing and illustrating those pathological problems which are likely to be encountered in the foetus and neonate.

The present volume deals with specific aspects of neuropathology for forensic and clinical neuropathologists, with particular emphasis on their relevance to everyday practice. Each chapter includes an overview of the literature as well as specific references and features a wealth of figures, graphs, and tables.

Etiology-Based Dental and Craniofacial Diagnostics explores the role of embryology and fetal pathology in the assessment, diagnosis, and subsequent treatment planning of a wide range of disorders in the dentition and craniofacial region. Initial chapters cover various aspects of normal dental and craniofacial development, providing the necessary biological background for understanding abnormal patient cases. Chapters then focus on the etiology behind a wide range of cases observed in everyday practice—including deviations in tooth morphology and number, tooth eruption, root and crown resorption, and craniofacial malformations, disruptions and dysplasia. Unique new work from a leading authority in orthodontics, craniofacial embryology and fetal pathology Demonstrates how human prenatal development offers unique insights into postnatal diagnosis and treatment Clinical significance and implications are highlighted in summaries at the end of each chapter Ideal for postgraduate students in orthodontics, paediatric dentistry and oral medicine

Pathology of Multiple Pregnancy collates case material from over 500 autopsies (including embryos) and 1200 placentas from twins, triplets, and higher multiples with selected literature on human multiple reproduction. It emphasizes important new concepts of pathophysiology and interpretation of less than ideal outcomes of multiple conception based on over 30 years experience in the field. Aspects of perinatal pathology unique to twins and higher multiples are emphasized, with practical suggestions for the service pathologist, including items of potential medico-legal significance. Controversial topics, such as the value of studies of concordance for diseases or malformations, and the significance of inter-twin anastomoses, are addressed and suggestions made for further investigation. A close working relationship between pathologists and clinical colleagues is encouraged by discussion of clinico-pathological correlations. And, the most recent discussions on mechanisms of twinning and genetic versus environmental influences on the development of twins are presented.

Prenatal diagnosis is the most important and fast moving area in obstetrics. This important new title is intended to become the definitive international book on the subject. Features: * Strong editorial team - offering a combination of geneticist and obstetrician * Both editors are of renowned international standing * Expert contributors from the UK, USA, Europe and Australia * Final chapter will summarise the major developments in the field - cross-referenced to and from the relevant chapters * Current, in-depth coverage of prenatal diagnosis

New to the third edition: - revised chapter on the central nervous system - new chapter on AIDS - expanded section on bone marrow diseases - new entities identified since 1989 - new data to help date fetuses

Describes and illustrates the range of pathological abnormality encountered, whether in spontaneous abortion or following termination for recognized foetal anomaly. A short, didactic account of foetal pathology which should be of interest to all surgical pathology departments.

Stillbirth remains a sufficiently frequent outcome of pregnancy to pose great problems for clinicians, who have to treat extremely distressed patients. This concise but comprehensive book from an international team of contributors sets out clear guidelines for clinical procedures and patient management for the obstetrician, as well as the gynecolog

This book provides a comprehensive overview of the development of the human central nervous system (CNS) in the context of its many developmental disorders due to genetic, environmental and hypoxic/ischaemic causes. The book contains three general, introductory chapters in which an overview of the development of the human brain and spinal cord, a summary of mechanisms of development as obtained in experimental studies in various invertebrates and vertebrates, and an overview of the causes of congenital malformations are presented. The developmental disorders of the human brain and spinal cord are presented in a regional, more or less segmental way, starting with neurulation and neural tube defects, and ending with developmental disorders of the cerebral cortex. These chapters are abundantly illustrated in colour with carefully chosen clinical case studies with imaging data, and when available, postmortem verification of the developmental disorders involved. In the third edition, more emphasis has been given to the developmental ontology based on the prosomeric approach, and fetal development. Prenatal diagnosis by ultrasound, MRI and DTI, and classifications of developmental disorders have been updated. A number of new Clinical Cases have been included. Several new co-authors participate in various chapters. The book is intended for advanced medical students, and all those clinicians working with children and adults with developmental disorders of the CNS. Unique to the book is the integration of data from human embryology, experimental and molecular findings in mice in particular, imaging and developmental neuropathology.