Many applications follow the distributed computing paradigm, in which parts of the application are executed on different network-interconnected computers. The extension of these applications in terms of number of users or size has led to an unprecedented increase in the scale of the infrastructure that supports them. Large-Scale Distributed Computing and Applications: Models and Trends offers a coherent and realistic image of today's research results in large scale distributed systems, explains state-of-the-art technological solutions for the main issues regarding large scale distributed systems, and presents the benefits of using large scale distributed systems and the development process of scientific and commercial distributed applications.

This book constitutes the thoroughly refereed proceedings of the 22st International Conference on Computer Networks, CN 2015, held in Brunów, Poland, in June 2015. The 42 revised full papers presented were carefully reviewed and selected from 79 submissions. The papers in these proceedings cover the following topics: computer networks, distributed computer systems, communications and teleinformatics.

"This book reviews methodologies in computer network simulation and modeling, illustrates the benefits of simulation in computer networks design, modeling, and analysis, and identifies the main issues that face efficient and effective computer network simulation"--Provided by publisher.

Complex systems modeling and simulation approaches are being adopted in a growing number of sectors, including finance, economics, biology, astronomy, and many more. Technologies ranging from distributed computing to specialized hardware are explored and developed to address the computational requirements arising in complex systems simulations. The aim of this book is to present a representative overview of contemporary large-scale computing technologies in the context of complex systems simulations applications. The intention is to identify new research directions in this field and to provide a communications platform facilitating an exchange of concepts, ideas and needs between the scientists and technologist and complex system modelers. On the application side, the book focuses on modeling and simulation of natural and man-made complex systems. On the computing technology side, emphasis is placed on the distributed computing approaches, but supercomputing and other novel technologies are also considered.

Approx.236 pages

Comprehensive Medicinal Chemistry III, Eight Volume Set provides a contemporary and forward-looking critical analysis and summary of recent developments, emerging trends, and recently identified new areas where medicinal chemistry is having an impact. The discipline of medicinal chemistry continues to evolve as it adapts to new opportunities and strives to solve new challenges. These include drug targeting, biomolecular therapeutics, development of chemical biology tools, data collection and analysis, in silico models as predictors for biological properties, identification and validation of new targets, approaches to quantify target engagement, new methods for synthesis of drug candidates such as green chemistry, development of novel scaffolds for drug discovery, and the role of regulatory agencies in drug discovery. Reviews the strategies, technologies, principles, and applications of modern medicinal chemistry Provides a global and current perspective of today's drug discovery process and discusses the major therapeutic classes and targets Includes a unique collection of case studies and personal assays reviewing the discovery and development of key drugs

One of the most challenging issues in today’s large-scale computational modeling and design is to effectively manage the complex distributed environments, such as computational clouds, grids, ad hoc, and P2P networks operating under various types of users with evolving relationships fraught with uncertainties. In this context, the IT resources and services usually belong to different owners (institutions, enterprises, or individuals) and are managed by different administrators. Moreover, uncertainties are presented to the system at hand in various forms of information that are incomplete, imprecise, fragmentary, or overloading, which hinders in the full and precise resolve of the evaluation criteria, subsequencing and selection, and the assignment scores. Intelligent scalable systems enable the flexible routing and charging, advanced user interactions and the aggregation and sharing of geographically-distributed resources in modern large-scale systems. This book presents new ideas, theories, models, technologies, system architectures and implementation of applications in intelligent scalable computing systems. In 15 chapters, several important Artificial Intelligence-based techniques, such as fuzzy logic, neural networks, evolutionary, and memetic algorithms are studied and implemented. All of those technologies have formed the foundation for the intelligent scalable computing that we know of today. We believe that this book will serve as a reference for students, researchers, and industry practitioners working or interested in joining interdisciplinary research in the areas of intelligent decision systems using emergent distributed computing paradigms. It will also allow newcomers (students and researchers alike) to grasp key issues and potential solutions on the selected topics. This book presents new ideas, theories, models, technologies, system architectures and implementation of applications in intelligent scalable computing systems. In 15 chapters, several important Artificial Intelligence-based techniques, such as fuzzy logic, neural networks, evolutionary, and memetic algorithms are studied and implemented. All of those technologies have formed the foundation for the intelligent scalable computing that we know of today. We believe that this book will serve as a reference for students, researchers, and industry practitioners working or interested in joining interdisciplinary research in the areas of intelligent decision systems using emergent distributed computing paradigms. It will also allow newcomers (students and researchers alike) to grasp key issues and potential solutions on the selected topics.

Digital computers are now used routinely in on-line control systems. As applications become more complex and costs of developing software rise, the need for good software tools becomes vital. This volume presents 14 papers on the most recent developments within real-time programming - languages for real-time programming, software development tools and the application of real-time systems within industry.

This book constitutes the proceedings of the 9th International Conference on Internet and Distributed Computing Systems, IDCS 2016, held in Wuhan, China, in September 2016. The 30 full papers and 18 short papers presented in this volume were carefully reviewed and selected from 78 submissions. They were organized in topical sections named: body sensor networks and wearable devices; cloud computing and networking; distributed computing and big data; distributed scheduling and optimization; internet of things and its application; smart networked transportation and logistics; and big data and social networks.

This volume provides a state-of-the-art review of the development and future use of man-machine systems in all aspects of business and industry. The papers cover such topics as human-computer interaction, system design, and the impact of automation in general, and also by the use of case studies describe a wide range of applications in such areas as office automation, transportation, power plants, machinery and manufacturing processes and defence systems. Contains 73 papers.