This e-book series presents readers with information about state-of-the-art developments in clinical and pre-clinical cardiovascular magnetic resonance imaging (MRI).The first volume of the series brings contributions from prominent scientists and the to

MRI techniques have been recently introduced for non-invasive qualification of regional myocardial mechanics, which is not achievable with other imaging modalities. Covering more than twenty-three years of developments in MRI techniques for accessing heart mechanics, this book provides a plethora of techniques and concepts that assist readers choose the best technique for their purpose. It reviews research studies and clinical trials that implemented MRI techniques for studying heart mechanics.

SECTION 1: BASICS 1. Basics of Cardiac Computed Tomography 2. Basics of Cardiac Magnetic Resonance Imaging 3. New Cardiac Cameras: Single-photon Emission Computed Tomography and Positron Emission Tomography SECTION 2: HYPERTENSION 4. Left Ventricular Hypertrophy Evaluation by Echocardiography in Hypertension 5. Left Atrial Volume Index Evaluation by Echocardiography in Hypertension 6. Advances in Diastology by Echocardiography in Hypertension 7. Advances in Left Atrial Strain Evaluation by Echocardiography in Hypertension 8. Sequential ABPM Navigation Imaging in Hypertension 9. Echocardiographic Evaluation in Hypertension: Diagnostic, Prognostic, and Therapeutic Implications 10. Beta-blocker Effect and Outcome Evaluation by Echocardiography in Hypertension 11. Statin Effect and Outcome Evaluation by Echocardiography 12. ARNIs Effect and Outcome Evaluation by Echocardiography in Hypertension 13. Left Ventricular Hypertrophy and Left Ventricular Mass Index Evaluation by 3D Echocardiography in Hypertension 14. Validation of Chlorthalidone Efficacy and Outcome by Echocardiographic Variables 15. Secondary Hypertension Evaluation: Multimodality Imaging SECTION 3: HEART FAILURE 16. Biomarkers Imaging in Heart Failure 17. Advances in Systolic Heart Failure Evaluation by Echocardiography 18. Cardiac Magnetic Resonance Imaging in Ischemic Heart Failure 19. Role of Cardiovascular Magnetic Resonance Imaging in Nonischemic Cardiomyopathy 20. Echocardiography-guided b-blocker Therapy in Heart Failure 21. Diuretics Effect and Outcome Evaluation in Heart Failure by Echocardiography 22. Device Intervention in Heart Failure 23. Radionuclide Imaging of Cardiac Autonomic Innervation: MIBG 24. Cardiac Radionuclide Imaging to Assess Patients with Heart Failure SECTION 4: ST-ELEVATION MYOCARDIAL INFARCTION AND CORONARY ARTERY DISEASE 25. Biomarkers Imaging in ST-elevation Myocardial Infarction 26. Electrocardiography Imaging in ST-elevation Myocardial Infarction 27. Advances in Echocardiographic Navigation of STEMI Complications 28. Coronary Artery Disease and Advances in Intravascular Ultrasound Imaging 29. Vulnerable Plaque Imaging in Acute Coronary Syndrome: When to Intervene? 30. ST-elevation Myocardial Infarction and Advances in Optical Coherence Tomography 31. Role of OCT in the Subset of CAD Postpercutaneous Coronary Intervention and Postcoronary Artery Bypass Graft 32. Acute Coronary Syndrome: Bifurcation Lesion, Imaging, and Intervention Advances 33. Quantitative Assessment of Myocardial Blood Flow and Fractional Flow Reserve and their Clinical Applications 34. ACS Coronary Intervention and Imaging: Recent Advances--Optical Coherence Tomography 35. Advances in CT Coronary Angiography in Evaluation of CAD 36. TNK Effect and Outcome Evaluation in STEMI by Echocardiography 37. Prognosis and Risk Outcome by Echocardiography in AMI Patients Post-thrombolysis 38. TNK Effect and Outcome Evaluation in STEMI by Coronary Angiography 39. Thrombolytic Therapy Effect/Outcome Evaluation by Intravascular Ultrasound 40. Role of Myocardial Perfusion Imaging in Patients of Chronic Stable Angina 41. STEMI Intervention: Femoral versus Radial by Conventional Coronary Angiography 42. ARBs, ACEIs Effect and Outcome Evaluation in STEMI by Echocardiography 43. Beta Blockers Effect and Outcome Evaluation in STEMI by Echocardiography 44. Post-PCI Effect and Evaluation in STEMI by Echocardiography 45. Coronary Artery Disease Evaluation by Coronary Doppler Imaging 46. Dobutamine Stress Echocardiography in Assessment of Myocardial Viability 47. Assessment of Myocardial Viability: Advantag

This book presents a review of recent developments in NMR applications in pharmaceutical research. Consideration is given to consolidated and emerging techniques and methods in NMR, many of which are not widely applied but are likely to provide new opportunities for drug design. The first part of the book is dedicated to the description of NMR as a tool for the analysis of chemicals and interaction with targets. Particular emphasis is put on applications with unexploited potential for drug discovery and development. The next seven chapters describe NMR approaches to investigate in vivo models of interest in drug discovery and development, with the attention focused on anatomy, function, metabolism and molecular-cellular aspects. Finally, consideration is given to the application of in vivo NMR to the identification and characterization of biomarkers with the aim of monitoring the outcome of therapeutic intervention in selected human diseases, including the study of drug metabolism and toxicity. Aimed at NMR spectroscopists and pharmaceutical scientists, this title will be invaluable at putting NMR within context in its role in drug discovery and development. This resource will be essential reading for those both new and already active in these areas.

This comprehensive book focuses on multimodality imaging technology, including overviews of the instruments and methods followed by practical case studies that highlight use in the detection and treatment of cardiovascular diseases. Chapters cover PET-CT, SPECT-CT, SPECT-MRI, PET-MRI, PET-optical imaging, SPECT-optical imaging, photoacoustic Imaging, and hybrid intravascular imaging. It also addresses the important issues of multimodality imaging probes and image quantification. Readers from radiology and cardiology as well as medical imaging and biomedical engineering will learn essentials of the field. They will be shown how the field has advanced quantitative analysis of molecularly targeted imaging through improvements in the reliability and reproducibility of imaging data. Moreover, they will be presented with quantification algorithms and case illustrations, including coverage of such topics such as multimodality image fusion and kinetic modeling. Yi-Hwa Liu, PhD is Senior Research Scientist in Cardiovascular Medicine at Yale University School of Medicine and Technical Director of Nuclear Cardiology at Yale New Haven Hospital. He is also an Associate Professor (Adjunct) of Biomedical Imaging and Radiological Sciences at National Yang-Ming University, Taipei, Taiwan, and Professor (Adjunct) of Biomedical Engineering at Chung Yuan Christian University, Taoyuan, Taiwan. He is an elected senior member of Institute of Electrical and Electronic Engineers (IEEE) and a full member of Sigma Xi of The Scientific Research Society of North America. Albert J. Sinusas, M.D., FACC, FAHA is Professor of Medicine (Section of Cardiovascular Medicine) and Radiology and Biomedical Imaging, at Yale University School of Medicine, and Director of the Yale Translational Research Imaging Center (Y-TRIC), and Director of Advanced Cardiovascular Imaging at Yale New Haven Hospital. He is a recipient of the Society of Nuclear Medicine’s Hermann Blumgart Award.

This book focuses on the practical issues of the implementation of state-of-the-art acquisition methodologies and protocols for both basic science and clinical practice. It is a practical guidebook for both beginners and advanced users for easy and practical implementation of acquisition protocols. It is relevant for a wide audience that ranges from students, residents, fellows, basic scientists, physicists, engineers, and medical practitioners. The novelty of this book relates to its intended practical use and focus on state-of-the-art cardiac MRI techniques that span both the clinical and basic science fields. In comparison and contrast to other pre-existing books, this book will distinguish from others for its practical usefulness and conciseness. Correspondingly, the book will be used as a handbook (quick reference) for new starters or people who would like to establish state-of-the-art cardiac MRI techniques in their institutions. Given the historical evolution of technique development in MRI, the clinical and basic science topics will be described separately. However, in instances where basic science development complemented (or is envisaged to complement) clinical development (e.g., Diffusion MRI and tractography), every effort will be made to allow a comprehensive review and associations of the clinical/basic science subfields.

This extensively illustrated volume has been specifically geared towards optimal use of MRI systems. The text provides essential theoretical background information: Imaging acquisition and potential pitfalls are also examined in detail. Most importantly, structured guidelines are provided on the interpretation of clinical data in the wide range of cardiac pathology that can be encountered.

The discovery and development of a biological active molecule with therapeutic properties is an ever increasing complex task, highly unpredictable at the early stages and marked, in the end, by high rates of failure. As a consequence, the overall process leading to the production of a successful drug is very costly. The improvement of the net outcome in drug discovery and development would require, amongst other important factors, a good understanding of the molecular events that characterize the disease or pathology in order to better identify likely targets of interest, to optimize the interaction of an active agent (small molecule or macromolecule of natural or synthetic origin) with those targets, and to facilitate the study of the pharmacokinetics, pharmacodynamics and toxicity of an active agent in suitable models and in human subjects. The objective of this Research Topic is to highlight new developments and applications of imaging techniques with the objective of performing pharmacological studies in vivo, in animal models and in humans. In the domain of drug discovery, the pharmacological and biomedical questions constitute the center of attention. In this sense, it is fundamental to keep in mind the strengths and limitations of each analytical or imaging technique. At the end, the judicious application of the technique with the aim of supporting the search for answers to manifold questions arising during a long and painstaking path provides a continuous role for imaging within the complex area of drug discovery and development.

Cardiovascular Magnetic Resonance provides you with up-to-date clinical applications of cardiovascular MRI for the broad spectrum of cardiovascular diseases, including ischemic, myopathic, valvular, and congenital heart diseases, as well as great vessel and peripheral vascular disease. Editors Warren J. Manning and Dudley J. Pennell and their team of international contributors cover everything from basic MR physics to sequence design, flow quantification and spectroscopy to structural anatomy and pathology. Learn the appropriate role for CMR in a variety of clinical settings with reference to other modalities, practical limitations, and costs. With the latest information on contrast agents, MR angiography, MR spectroscopy, imaging protocols, and more, this book is essential for both the beginner and expert CMR practitioner. Covers both the technical and clinical aspects of CMR to serve as a comprehensive reference. Demonstrates the full spectrum of the application of cardiac MR from ischemic heart disease to valvular, myopathic, pericardial, aortic, and congenital heart disease. Includes coverage of normal anatomy, orientation, and function to provide you with baseline values. Discusses advanced techniques, such as interventional MR, to include essential information relevant to the specialist. Features appendices with acronyms and CMR terminology used by equipment vendors that serve as an introduction to the field. Uses consistent terminology and abbreviations throughout the text for clarity and easy reference. Covers both the technical and clinical aspects of CMR to serve as a comprehensive reference. Demonstrates the full spectrum of the application of cardiac MR from ischemic heart disease to valvular, myopathic, pericardial, aortic, and congenital heart disease. Includes coverage of normal anatomy, orientation, and function to provide you with baseline values. Discusses advanced techniques, such as interventional MR, to include essential information relevant to the specialist. Features appendices with acronyms and CMR terminology used by equipment vendors that serve as an introduction to the field. Uses consistent terminology and abbreviations throughout the text for clarity and easy reference.