Providing practical, visually oriented guidance on the benefits of botulinum toxin in a wide variety of disorders, some new and unexpected, this new edition of Manual of Botulinum Toxin Therapy is fully updated in scope and detail. Chapters discuss the pathophysiology of each condition, summarizing the rationale for botulinum toxin, and describing the injection approach. Clear illustrations of the injection sites are included, using a 'clinician's eye' perspective, which allows physicians to readily identify anatomical landmarks and approach angles for injection. Dosing tables for available toxin formulations are included. The Manual covers cosmetic treatment of the upper and lower face, as well as aesthetic smile correction. Extensive guidance on how to use ultrasound and how cadaveric dissections can assist localization and targeting of injections is provided. Designed for teaching and bedside guidance, the Manual is useful to a diverse range of clinicians looking to use botulinum toxin in their practice.

Introductory Chapter: Botulinum Toxin Type A Therapy in Dystonia and Spasticity - What are Current Practical Applications?

In a rapidly progressing field, Botulinum Toxin Therapy provides both clinicians and basic researchers with the latest science on the structure and function of botulinum toxins and the use of these toxins to treat a wide variety of diseases. Part 1 of the book reviews the basic science of botulinum toxins including advances in our understanding of the molecular structure and mechanism of action of botulinum toxins. This section also discusses the manufacturing and formulation of botulinum toxins for clinical use and the development of novel therapeutic toxins for the future. Part 2 reviews the use of botulinum toxins in clinical practice. It discusses the clinical pharmacology of botulinum toxin drugs and their use in a wide variety of clinical conditions including headache, spasticity, pain, disorders of the genitourinary and gastrointestinal tract, strabismus, and medical aesthetics.

Very few therapeutic agents in clinical medicine have found indication for so many clinical conditions, and in such a short time as did botulinum neurotoxins (Botox and others). Chronic migraine, bladder dysfunction , dystonia, hemifacial spasm , blepharospasm , drooling, excessive sweating and spasticity are all approved by FDA and many other indications are in the near horizon . The aesthetic/cosmetic use of Botox and other BoNTs already has a huge market worldwide. Stroke, Multiple sclerosis, Parkinson’s disease, Cerebral palsy as well as brain and spinal injury are among clinical conditions in which some of patients’ major symptoms can respond to botulinum toxin therapy Several books have been written on the subject of Botox and other neurotoxins for treatment of medical disorders ( including two books by Jabbari both published by Springer 2015 & 2017). However, despite the huge interest and enthusiasm of the public to learn more about Botox and other toxins, there is currently no book in the market on this subject which is specifically designed to inform and educate the public on botulinum toxin therapy. Botulinum Toxin Treatment explains and discusses in simple language the structure and function of botulinum toxin and other neurotoxins as well as the rational for its utility in different disease conditions. Safety, factors affecting efficacy and duration of action, as well as cost and insurance issues are also addressed.

Provides practical guidance on the use of botulinum toxin in a wide variety of disorders, in many areas of medicine. Using clear line drawings, it describes the relevant injection sites for each condition and gives comparative dosage tables for the various formulations of toxin used in different muscle groups.

This book provides an authoritative overview of botulinum neurotoxin (BoNT) treatment menus for 16 pain categories with an evidence-based literature review on each pain disorder, illustrative figures showing anatomy and techniques Introductory chapters cover basic information about the mechanism, function and the analgesic effects of the BoNTs based on the data derived from animal studies. Clinical chapters define pain in conditions such as post-herpetic and post-traumatic neuralgias, plantar fasciitis, low back pain, post-surgical pain syndromes and migraine in detail, provide discussion of current modes of treatment and updated information on BoNT therapy. Each chapter also includes illustrative case histories. The new edition is updated with all the new findings since the explosion in research and literature since 2015. New chapters on the history and pain in dentistry round out the update. Botulinum Toxin Treatment of Pain Disorders provides an invaluable resource for clinicians and researchers involved in the treatment of pain disorders including neurologists, pain medicine specialists, anesthesiologists, internists, those conducting research in pharmacology and toxicology as well as students in these areas.

This book offers a comprehensive approach to the wide range of movement disorders, an important specialty in the field of neurology, guiding readers from the phenomenology to diagnosis and management. Reflecting the latest developments in the field, it offers a unique summary of this dynamic area by pursuing a uniform approach to movement disorders curricula. Divided into three parts, Movement Disorders Curricula provides an authoritative overview of this growing branch of neurology. The first part presents the basic elements of movement disorders, including descriptions of the anatomy and physiology of the basal ganglia. It also features sections on clinical trials for movement disorders, practical skills, and rating scales. The second and third part examine in detail hypokinetic and hyperkinetic movement disorders, respectively. Equipping readers with the practical and research skills needed in the movement disorders field, the book offers a valuable tool to help them prepare for board examinations on general neurology, as well as for fellowships in movement disorders.

All books on the market which have been written on the subject of botulinum toxin therapy focus on treatment of hyperactive movement disorders, autonomic dysfunction (bladder, sweat and salivary glands) and some pain indications (migraine). Reference to pre-or post -surgical indications are brief and often out-dated. No book has information on dentistry or veterinary medicine. This book provides up-to-date information on botulinum toxin therapy in surgical fields. It is also the only book in the market that provides information on botulinum toxin therapy in dentistry and veterinary medicine, furnishing the latest information. Botulinum Toxin Treatment in Surgery, Dentistry, and Veterinary Medicine appeals to many disciplines including surgery, dentistry and veterinary medicines well as appealing to neurologists and internists.

Since publication of the first edition, Spasticity: Diagnosis and Management has been the defining reference and go-to source for physicians, therapists, and other healthcare providers who care for patients with spasticity. For this new updated edition, Dr. Brashear and a diverse team of specialists have come together to integrate new research, clinical trials, measurement tools, therapies, and other recent advances that reflect this evolving field. The book is organized into four sections, each of which covers a broad scope of material. The first is a general overview of spasticity and its effects on movement in patients. Other chapters cover epidemiology and ancillary findings commonly associated with spasticity. Part II details assessment tools and measurements, treatment goals, and how to aim for realistic outcomes. Part III outlines various treatment modalities, including heavily updated chapters on the use of botulinum toxin in the upper and lower extremities, guidance techniques for injections, intrathecal baclofen, neuromodulation, surgery, physical therapy, and more. The last section, which contains several new chapters, discusses evaluation of outcomes and management of patients with stroke, traumatic brain injury, spinal cord injuries, multiple sclerosis, cerebral palsy, and cancer, followed by chapters on spasticity management in long-term care facilities and economic considerations. This book remains the most comprehensive guide to diagnosis and management of spasticity in adults and children, and the revised second edition will continue to serve as an invaluable resource for professionals in any discipline who strive to provide quality care to spasticity patients. Key Features: Revised edition of the premier clinical reference on spasticity Incorporates the latest advances in assessment and treatment Contains six entirely new chapters highlighting key topics including Tardieu scale and other measurement tools, ultrasound guidance for botulinum toxin management, spasticity in special populations, emerging therapies, and economic impact More than 200 figures and 70 tables accompany the updated text

This issue of Neurologic Clinics, guest edited by Dr. José Biller, is devoted to Therapy in Neurology. This issue is one of four selected each year by the series Consulting Editor, Dr. Randolph W. Evan. Articles in this issue include: Update on CGRP Antagonism in the Treatment of Migraine, Advances in the Treatment of Multiple Sclerosis, Advances in the Treatment of Neuromyelitis Optica Spectrum Disorder, Advances and ongoing controversies in PFO closure and cryptogenic stroke, Advances in neuromodulation/neurostimulation in Neurology, Advances in the treatment of muscular dystrophies and motor neuron disorders, Advances in the management of small fiber neuropathies, Update in the treatment of Idiopathic Intracranial Hypertension, What is new in neuro-oncology?, Advances in the surgical management of epilepsy, Treatment of Viral Encephalitis, An update on Botulinum toxin in neurology, Cannabinoids in neurological illnesses, and Pitfalls in Transitioning Neurological Care of the Developmentally Disabled from Pediatric to Adult Providers.