This volume highlights problems from a range of biological and medical applications that can be interpreted as questions about system behavior or control. Topics include drug resistance in cancer and malaria, biological fluid dynamics, auto-regulation in the kidney, anti-coagulation therapy, evolutionary diversification and photo-transduction. Mathematical techniques used to describe and investigate these biological and medical problems include ordinary, partial and stochastic differentiation equations, hybrid discrete-continuous approaches, as well as 2 and 3D numerical simulation.

Introduces biological concepts and biotechnologies producing the data, graph and network theory, cluster analysis and machine learning, using real-world biological and medical examples.

Computational biology, mathematical biology, biology and biomedicine are currently undergoing spectacular progresses due to a synergy between technological advances and inputs from physics, chemistry, mathematics, statistics and computer science. The goal of this book is to evidence this synergy by describing selected developments in the following fields: bioinformatics, biomedicine and neuroscience. This work is unique in two respects - first, by the variety and scales of systems studied and second, by its presentation: Each chapter provides the biological or medical context, follows up with mathematical or algorithmic developments triggered by a specific problem and concludes with one or two success stories, namely new insights gained thanks to these methodological developments. It also highlights some unsolved and outstanding theoretical questions, with a potentially high impact on these disciplines. Two communities will be particularly interested in this book. The first one is the vast community of applied mathematicians and computer scientists, whose interests should be captured by the added value generated by the application of advanced concepts and algorithms to challenging biological or medical problems. The second is the equally vast community of biologists. Whether scientists or engineers, they will find in this book a clear and self-contained account of concepts and techniques from mathematics and computer science, together with success stories on their favorite systems. The variety of systems described represents a panoply of complementary conceptual tools. On a practical level, the resources listed at the end of each chapter (databases, software) offer invaluable support for getting started on a specific topic in the fields of biomedicine, bioinformatics and neuroscience.

Thanks to recent advancements, optimization is now recognized as a crucial component in research and decision-making across a number of fields. Through optimization, scientists have made tremendous advances in cancer treatment planning, disease control, and drug development, as well as in sequencing DNA, and identifying protein structures. Op

Dr. Smirnova's updated text is devoted to the theoretical studies of radiation effects on mammals. It summarizes 35 years of results the author obtained from analyzing dose rate equivalents for the Galactic Cosmic Rays (GCR) and for Solar Particles Events (SPE). This edition also includes two new chapters on skin epidermal epithelium and risk assessment for myeloid leukemia, as well as extended revisions addressing the radiation effects on the blood-forming system. Mathematical models are used to explain the effects of both acute and chronic irradiation on the dynamics of vital body systems, like the hematopoietic system, the development of autoimmune diseases, and the mortality dynamics in homogeneous and nonhomogeneous mammalian populations. The proposed methodology of these studies, the models themselves, and the obtained results are of a great theoretical significance and can find wide practical use.

A man disappears. The woman who loves him is left scarred and haunted. In her fierce, one-of-a-kind debut, Rebecca Lindenberg tells the story—in verse—of her passionate relationship with Craig Arnold, a much-respected poet who disappeared in 2009 while hiking a volcano in Japan. Lindenberg’s billowing, I-contain-multitudes style lays bare the poet’s sadnesses, joys, and longings in poems that are lyric and narrative, at once plainspoken and musically elaborate. Regarding her role in Arnold’s story, Lindenberg writes with clear-eyed humility and endearing dignity: “The girl with the ink-stained teeth / knows she’s famous / in a tiny, tragic way. / She’s not / daft, after all.” And then later, playfully, of her travels in Italy with the poet, her lover: “The carabinieri / wanted to know if there were bears / in our part of America. Yes, we said, / many bears. Man-eating bears? Yes, of course, / many man-eating bears.” Every poem in this collection bursts with humor, pathos, verve—and an utterly unique, soulful voice. This widely anticipated debut, already selected as a finalist for several prominent book awards, marks the first collection in the newly minted McSweeney’s Poetry Series. MPS is an imprint which seeks to publish a broad range of excellent new poetry collections in exquisitely designed hardcovers—poetry that’s useful and meaningful to anyone in any walk of life.

Explains how nursing informatics relates to knowledge acquisition, knowledge processing, knowledge generation, and knowledge dissemination and feedback, all of which build the science of nursing.

The lack of scientists equally trained and prepared to understand both mathematics and biology/medicine hampers the development and application of computer simulation methods in biology and neurogastrobiology. Currently, there are no texts for navigating the extensive and intricate field of mathematical and computational modeling in neurogastrobiology. This book bridges the gap between mathematicians, computer scientists and biologists, and thus assists in the study and analysis of complex biological phenomena that cannot be done through traditional in vivo and in vitro experimental approaches. The book recognizes the complexity of biological phenomena under investigation and treats the subject matter with a degree of mathematical rigor. Special attention is given to computer simulations for interpolation and extrapolation of electromechanical and chemoelectrical phenomena, nonlinear self-sustained electromechanical wave activity, pharmacological effects including co-localization and co-transmission by multiple neurotransmitters, receptor polymodality, and drug interactions. Mathematical Modeling and Simulation in Enteric Neurobiology is an interdisciplinary book and is an essential source of information for biologists and doctors who are interested in knowing about the role and advantages of numerical experimentation in their subjects, as well as for mathematicians who are interested in exploring new areas of applications.