Subjective cognitive decline (SCD) with self-reported concerns and mild cognitive impairment (MCI) are well-established to be at increased risk of developing Alzheimer’s disease (AD) dementia and a clinical continuum of dementia progression as a spectrum of AD. AD may develop from SCD to MCI (early MCI and late MCI) and eventually to AD. Nevertheless, until recently little was known about their pathophysiology associated with cognitive-behavioral syndrome. Although for researchers, scientists and clinicians, the pathophysiology of AD spectrum is an intriguing issue, delineating it in a clear way is far from easy. Taken together, in-depth understanding of neuroimaging-based pathology behind cognitive impairments across AD spectrum may help to develop new strategy for the early diagnosis and treatment of AD. Neuroimaging has been thought to potentially reveal the pathological mechanisms of AD progression. Individuals across AD spectrum are often associated with anatomical and functional brain alterations and cognitive impairment, most of the pathophysiology will focus primarily on the brain. To investigate brain structures and functions associated with cognition, neuroimaging will be the most appropriate tool.

"Provides a unique perspective. I am particularly impressed with the sections on innovative design and methods to investigate cognitive aging and the integrative perspectives. None of the existing texts covers this material to the same level." —Donna J. La Voie, Saint Louis University "The emphasis on integrating the literature with theoretical and methodological innovations could have a far-reaching impact on the field." —Deb McGinnis, Oakland University The Handbook of Cognitive Aging: Interdisciplinary Perspectives clarifies the differences in patterns and processes of cognitive aging. Along with a comprehensive review of current research, editors Scott M. Hofer and Duane F. Alwin provide a solid foundation for building a multidisciplinary agenda that will stimulate further rigorous research into these complex factors. Key Features Gathers the widest possible range of perspectives by including cognitive aging experts in various disciplines while maintaining a degree of unity across chapters Examines the limitations of the extant literature, particularly in research design and measurement, and offers new suggestions to guide future research Highlights the broad scope of the field with topics ranging from demography to development to neuroscience, offering the most complete coverage available on cognitive aging

Part of the authoritative Oxford Textbooks in Psychiatry series, Oxford Textbook of Old Age Psychiatry, Third Edition has been thoroughly updated to reflect the developments in old age psychiatry since publication of the Second Edition in 2013, and remains an essential reference for anyone interested in the mental health care of older people.