This book provides a comprehensive overview of modern computer-based techniques for analyzing the structure, properties and dynamics of biomolecules and biomolecular processes. It is organized in four main parts; the first one deals with methodology of molecular simulations; the second one with applications of molecular simulations; the third one introduces bioinformatics methods and the use of experimental information in molecular simulations; the last part reports on selected applications of molecular quantum mechanics. This second edition has been thoroughly revised and updated to include the latest progresses made in the respective field of research.

At times we take it for granted, it's just an extension of our arm, but how much do you know about the development of your fly rod? Don Phillips gives the reader a perspective of how fly-rod technology has evolved since the earliest Chinese and Egyptian fishermen fed their families more than 2000 years before the birth of Christ. In this book, Don shares: the history, including the very first rods; fly-rod design over the years; the use of cane, metal, fiberglass, and boron and graphite; the properties of these materials; manufacturing processes for these materials; component design; patent activities over the years; casting; taper and cross-sectional geometry; and much, much more. You'll find this very detailed book hard to put down.

This Research Topic is Volume II of a series. The previous volume can be found here: Coal and Rock Dynamic Disasters: Advances of Physical and Numerical Simulation in Monitoring, Early Warning, and Prevention With the soaring growth of global population and socioeconomy, energy consumption and demand has been rapidly rising, and coal would still remain a fundamental energy source for a long time into the future. Seeking deep coal resources becomes an inevitable trend due to the depletion of shallow coal resources. Deep mining of coal resources promotes socioeconomic development, whereas bringing a variety of security challenges. In deep underground, there is a significant risk increase in coal and rock dynamic disasters (CRDDs), owing to the changes in physical and mechanical properties of coal and rock. In this regard, it is of great importance and necessity to prevent and control CRDDs effectively and efficiently.

We humans are tribal, grouping ourselves by a multitude of criteria: physical, intellectual, political, emotional, etc. The Internet and its auxiliary technologies have enabled a novel dimension in tribal behavior during our recent past. This growing connectivity begs the question: will individuals and their communities come together to solve some very urgent global problems? At MMVR, we explore ways to harness information technology to solve healthcare problems - and in the industrialized nations we are making progress. In the developing world however, things are more challenging. Massive urban poverty fuels violence and misery. Will global networking bring a convergence of individual and tribal problem-solving? Recently, a barrel-shaped water carrier that rolls along the ground was presented, improving daily life for many people. Also the One Laptop per Child project is a good example of how the industrialized nations can help the developing countries. They produce durable and simple laptops which are inexpensive to produce. At MMVR, we focus on cutting-edge medical technology, which is generally pretty expensive. While the benefits of innovation trickle downward, from the privileged few to the broader masses, we should expand this trickle into a flood. Can breakthrough applications in stimulation, visualization, robotics, and informatics engender tools as ingeniously as the water carrier or laptop? With some extra creativity, we can design better healthcare for the developing world too.