Mechanisms and Genetics of Neurodevelopmental Cognitive Disorders connects neurodevelopment with genetics and behavior to better understand the underlying factors leading to cognitive neurodevelopmental disorders. This book focuses on mechanisms of disease and follows the development of specific brain regions, functions, and gene expression to causes and processes in autism, attention deficit disorder, and learning disabilities. Topics include brain mapping, brain plasticity, epigenetics, neuroimmunology, and many other factors that influence the development of these diseases. This book will promote understanding of recent investigations and developments related to brain development from fetal life onward with specific relevance to neurodevelopmental cognitive disorders and conditions. This is an essential reference for anyone who is looking to learn more about different aspects of neurodevelopment and emerging concepts in psychiatric disorders. Discusses links between brain development, gene expression, and brain function Covers neural stem cells, proliferation, migration, differentiation, and neurogenesis Includes brain mapping, brain plasticity, epigenetics, neuroimmunology, and more Provides insight into causation and brain function in autism, attention deficit disorder, and learning disabilities Examines impact of society and environmental factors on mental health

Neuroprotection is a novel perspective for the treatment of disorders that lead to neurodegeneration and disabilities as a result of deterioration of neurons due to apoptosis, oxidative stress, excitotoxicity, and other mechanisms. These mechanisms have implications not only for neurodegenerative disorders, but also for schizophrenia, mood and cognitive disorders. The purpose of this book is to provide an up-to-date overview of basic and clinical studies concerning the neuroprotective approach, mechanisms, and several compounds with neuroprotective properties that may contribute to more efficacious treatment of major mental health disorders. The book is divided into two sections. The first section serves as an introduction and overview of conceptual issues of the neuroprotective approach, and some neurobiological advances. Chapters in this section review definitions, perspectives, and issues that provide a conceptual base for the rest of the book. In addition, this part includes chapters in which the authors present and discuss the findings from basic studies of neurodegenerative mechanisms that are associated with the pathogenesis of major mental health disorders. The second section focuses on findings obtained from clinical trials with neuroprotective compounds, and neuromodulatory techniques. The take-home message is that principles of the neuroprotective approach may be applied to treatment of schizophrenia, mood and cognitive disorders. Contributors to this book are among the most active investigators and clinicians in the field who provide new perspectives not only clarifying ongoing controversies but also propose diverse aspects and new insights to neuroprotection. This book is intended for a broad readership, which includes a broad spectrum of readers including neuroscientists, psychiatrists, neurologists, pharmacologists, clinical psychologists, general practitioners, geriatricians, graduate students, and policy makers in the fields of mental health.

Neurodevelopmental disorders arise from disturbances to various processes of brain development, which can manifest in diverse ways. They encompass many rare genetic syndromes as well as common, heritable conditions such as intellectual disability, autism, ADHD, schizophrenia and many types of epilepsy. The Genetics of Neurodevelopmental Disorders examines recent revolutionary advances in our understanding of the genetics of these disorders, exploring both basic discoveries and the translation of new findings into the clinical setting. The book begins by examining the genetic architecture and etiology of neurodevelopmental disorders. It describes the striking recent progress in identifying pathogenic mutations, which are grouped here based on the neurodevelopmental processes impacted. Subsequent chapters consider the use of cellular and animal models to elucidate the cascading consequences of such mutations, from molecular and cellular levels to emergent effects on neural circuits, brain systems and subsequent psychological development. The text concludes by examining the important clinical implications of the recent advances in the field, from recognition of the genetic causes in individual patients to development of new treatments and interventions. A timely synthesis, The Genetics of Neurodevelopmental Disorders is a unique and essential resource for neuroscientists, geneticists, neurologists and psychiatrists and an accessible and up-to-date overview for medical and science students.

Content Description #"A Bradford Book."#Includes bibliographical references and index.

Cardiovascular disease (CVD) and neurodevelopmental disorders (NDD) are both common diseases seriously affecting human health. CVD refers to a broad range of disorders including diseases affecting the vasculature, the myocardium, the heart’s electrical circuit, and congenital heart disease. NDDs are conditions affecting brain development and function, mainly characterized by impairments of cognition, communication, and motor skills. Although the heart and brain develop in spatially distinct regions, they share similar genetic factors and molecular pathways which are crucial for a precise developmental trajectory. Actually, congenital CVD survivors are at a higher risk of NDD, and whole-exome sequencing revealed a significant overlap between high-risk congenital CVD and NDD genetic variants. For CVD and NDD, the clinical presentations are heterogeneous, and the etiologies are complex. Elucidating the potential pathogenic mechanisms is good for unveiling the pathophysiology and finding the novel therapeutic target.

Cystic fibrosis (CF) is a chronic, life-threatening genetic disorder that impacts not only the respiratory and digestive systems but also an individual's psychological well-being. The continuous battle with illness, medical treatments, and the uncertainty of the future can leave profound emotional and mental imprints on patients and their families. In recent years, the importance of psychological support for those affected by CF has come to light, and among the various therapeutic approaches, Cognitive Behavioral Therapy (CBT) stands out as an effective method for managing the psychological toll of chronic illness. This book, Psychological Support by Cognitive Behavioral Therapy for Cystic Fibrosis, is designed to serve as a comprehensive guide for understanding the psychological challenges faced by CF patients and their families. It aims to highlight how CBT can provide effective tools to help them navigate these difficulties, from managing the trauma of diagnosis to coping with the ongoing physical and emotional pain associated with the disorder. The journey of living with a genetic illness like cystic fibrosis is often filled with uncertainty, fear, and emotional strain. For patients, the impact of the disease goes beyond the physical symptoms—it affects their identity, independence, relationships, and self-worth. Families, too, must cope with the overwhelming stress of caregiving, fear of the future, and the emotional exhaustion that comes with chronic illness. In this book, I combine essential knowledge about the biology, genetics, and medical challenges of CF with an introduction to CBT techniques that can be personalized to address these psychological struggles. I delve into the science behind cystic fibrosis and the complexities of genetic mutations that drive the condition. I also explore the impact of hereditary diseases and offer insights into how behavioral genetics and epigenetics play a role in CF and similar conditions. More than just a theoretical discussion, this book offers actionable tools and strategies based on CBT principles to help CF patients and their families manage anxiety, depression, chronic pain, and the everyday emotional hurdles they encounter. From practical tips on pain management to learning how to live a fulfilling life despite the challenges, this book is meant to be a practical guide for both mental health professionals and those directly affected by CF. I hope that this book can offer not only information but also hope and empowerment for individuals and families facing cystic fibrosis. By integrating psychological support into the treatment of CF, it is possible to improve the quality of life for everyone touched by this difficult journey.

What is attention? How does it go wrong? Do attention deficits arise from genes or from the environment? Can we cure it with drugs or training? Are there disorders of attention other than deficit disorders? The past decade has seen a burgeoning of research on the subject of attention. This research has been facilitated by advances on several fronts: New methods are now available for viewing brain activity in real time, there is expanding information on the complexities of the biochemistry of neural activity, individual genes can be isolated and their functions identified, analysis of the component processes included under the broad umbrella of "attention" has become increasingly sophisticated, and ingenious methods have been devised for measuring typical and atypical development of these processes, from infancy into childhood, and then into adulthood. In this book, Kim Cornish and John Wilding are concerned with attention and its development, both typical and atypical, particularly in disorders with a known genetic etiology or assumed genetic linkage. Tremendous advances across seemingly diverse disciplines - molecular genetics, pediatric neurology, child psychiatry, developmental cognitive neuroscience, and education - have culminated in a wealth of new methods for elucidating disorders at multiple levels, possibly paving the way for new treatment options. Cornish and Wilding use three specific-yet-interlinking levels of analysis: genetic blueprint (genotype), the developing brain, and the behavioral-cognitive outcomes (phenotype), as the basis for charting the attention profiles of six well-documented neurodevelopmental disorders: ADHD, autism, fragile X syndrome, Down syndrome, Williams syndrome, and 22q11 deletion syndrome. Their overarching aim in this book is to provide the most authoritative and extensive account to date of disorder-specific attention profiles and their development from infancy through adolescence.

As nutrition research is shifting its focus from epidemiology and physiology to effects of nutrients at the molecular level, a uniquely tailored diet that corresponds to the demands of our genetic signature is emerging as an indispensable need. Using high-throughput genomic tools, nutrigenomics unravels the influence of micro- and macronutrients as

This book is unique in presenting evidence on development across the lifespan across multiple levels of description (genetic, brain, cognitive, environmental). The authors use a well-defined disorder - Williams syndrome, to explore the impact of genes, brain development, behaviour, as well as the individual's environment on development.