Bacteria and fungi are able to aggregate together or on surfaces in densely packed microcolonies, facilitated by extracellular polymeric substances for cell protection and stability. These biofilms have proven to be extremely hard to eradicate and remove once established. In chronic infections, this condition can result in a high degree of morbidity and mortality as regular antibiotic treatments are ineffective against biofilms. In industrial facilities, the formation of biofilms can ruin production and result in enormous financial losses. In this book, the current state of antibiofilm research is presented by experts from around the world. Novel, cutting-edge techniques and new optimized strategies based on established methods are discussed in chapters focused on biofilm prevention, treatment and control for the application in clinical, industrial and veterinary settings. Antibiofilm strategies, such as chemical and enzymatic treatments, surface modification and coatings, quorum sensing inhibition and dispersal induction, phage therapy, cold plasma treatment, hyperbaric oxygen treatment, and metal-based nanomedicine are covered, among many others. This book contributes to the UN’s Sustainable Development Goal 3: Good Health and Well-Being and is a valuable resource for healthcare professionals, microbiologists, academics and for educators to inform curricula of universities and colleges.

The third edition of Textbook of Endodontology provides lucid scholarship and clear discussion of endodontic principles and treatment to dental students and dental practitioners searching for current information on endodontic theories and techniques. Completely revised and updated new edition Features six new chapters Provides pedagogical features to promote understanding Includes clinical case studies to put the information in the clinical context Illustrated in full color throughout with clinical images and detailed diagrams Offers interactive multiple-choice questions on a companion website

This eBook is a collection of articles from a Frontiers Research Topic. Frontiers Research Topics are very popular trademarks of the Frontiers Journals Series: they are collections of at least ten articles, all centered on a particular subject. With their unique mix of varied contributions from Original Research to Review Articles, Frontiers Research Topics unify the most influential researchers, the latest key findings and historical advances in a hot research area! Find out more on how to host your own Frontiers Research Topic or contribute to one as an author by contacting the Frontiers Editorial Office: frontiersin.org/about/contact.

Bioengineered Nanomaterials for Wound Healing and Infection Control is a key reference for those working in the fields of materials science, pharmacy, nanotechnology, biomedical engineering and microbiology. Bioengineered nanomaterials have unique physicochemical properties which promote accelerated wound healing and treatment of infections. The biosynthesis of these nanomaterials also offers a clean, safe and renewable alternative to traditional nanomaterials, helping reduce environmental impact alongside antibacterial resistance. - Provides an overview of the role of biofilms and multidrug resistance in wound infections - Covers a range of bioengineered nanomaterial types and nanotechnology-based approaches, including phyconanotechnology, phytonanotechnology and microbial nanotechnology - Helps readers discover novel materials for use in wound healing and infection control while reducing the probability of antibiotic resistance

The rapid increase in the emergence of antibiotic-resistant bacterial strains, combined with a dwindling rate of discovery of novel antibiotic molecules, has created an alarming issue worldwide. Although the occurrence of resistance in microbes is a natural process, the overuse of antibiotics is known to increase the rate of resistance evolution. Under antibiotic treatment, susceptible bacteria inevitably die, while resistant microorganisms proliferate under reduced competition. Therefore, the out-of-control use of antibiotics eliminates drug-susceptible species that would naturally limit the expansion of resistant species. In addition, the ability of many microbial species to grow as a biofilm has further complicated the treatment of infections with conventional antibiotics. A number of corrective measures are currently being explored to reverse or slow antibiotic resistance evolution, Among which one of the most promising solutions is the development of polymer-based antimicrobial compounds. In this Special Issue, different polymer systems able to prevent or treat biofilm formation, including cationic polymers, antibacterial peptide-mimetic polymers, polymers or composites able to load and release bioactive molecules, and antifouling polymers able to repel microbes by physical or chemical mechanisms are reported. Their applications in the design and fabrication of medical devices, in food packaging, and as drug carriers is investigated.

Applied Technologies for Clean Up of Environmental Contaminants covers the features of remediation and biocontrol technology, a multidisciplinary field combining environmental and industrial microbiology with biotechnology to improve environmental management. Studying the advanced microbial processes involved in geomicrobiology, aeromicrobiology, microbial loop and nutrient availability, as well as microbial energetics in the contaminated environment with an emphasis on innovative methodologies, the book provides readers with a better understanding of basic microbiology, allowing them to comprehend the mechanism and behavior of various biochemical processes that are used in bioremediation and biocontrol technologies.Including coverage of key subjects such as management of waste, energy generation, restoration processes, water treatment processes, co-metabolism, and nutrient recycling as well as emerging advances in environmental microbial biotechnology, green nanotechnology, metagenomic and proteomic strategies, DNA microarray, and biosensor-based technologies, this book provides potential implications for environmental management. - Includes microbially driven sequestration of environmental contaminants such as xenobiotics, heavy metals, petroleum-based pollutants, and other micropollutants - Overviews recent discoveries in geomicrobiology, aeromicrobiology, biocontrol, complex plant-microbe relationship, and microbial process energetics - Reviews promising ecologically benign technologies, such as waste valorization, biomining, the use of biosolids and microbial metabolites

Microbial biofilms: Role in Human Infectious Diseases focuses on new and emerging concepts in microbial biofilm research, such as the mechanisms of biofilm formation, biofilm-induced pathogenesis, biofilm detection/and diagnosis, gene exchange within biofilms, strategies to control microbial biofilms and the burden of biofilm associated infections. In addition, it highlights the various anti-biofilm strategies such as surface coating, signal quenching, novel compounds that can be translated to curb biofilm-associated infections and the escalation of antimicrobial resistance determinants. Microbial biofilms can be a serious problem in medical settings as they are associated with significant mortality and morbidity. Infection related to biofilms increases recovery time and the cost of disease management. Biofilms are resistant to known antibiotics and human defense mechanism. In addition, due to close proximity of microbes within biofilms, increase genetic transformation has been detected results in increases frequency of antibiotic gene spread. With the advancement in science and technology, novel strategies have been proposed to combat the impact of biofilms on human health. - Fulfills the knowledge gap in biofilm study - Focuses on new and emerging concepts in microbial biofilm research - Highlights the various anti-biofilm strategies - Provides concise, thorough and up-to-date information about the important role of microbial biofilms in human diseases