Public health and in health policy courses at the undergraduate and graduate level.

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The third volume in the Handbooks in Health Economic Evaluation series, this book provides the reader with a comprehensive set of instructions and examples of how to perform an economic evaluation of a health intervention. It focuses solely on cost-effectiveness analysis in health care. The book is developed out of the Advanced Methods of Cost-Effectiveness Analysis course taught at the University of Oxford and the four main sections mirror the four principal components of the course: Outcomes, Costs, Modelling using decision tress and Markov models, and Presenting cost-effectiveness results.&L ABOUT THE SERIES Series editors Alastair Gray and Andrew Briggs Economic evaluation of health intervention is a growing specialist field, and this series of practical handbooks tackles, in depth, topics superficially addressed in more general economics books. Each volume includes illustrative material, case histories and worked examples to encourage the reader to apply the methods discussed, with supporting material provided online. The series is for health economists in academia, the pharmaceutical industry and the health sector, those on advanced health economics courses, and health researchers in associated fields.

The second edition of this innovative work again provides a unique perspective on the clinical discovery process by providing input from experts within the NIH on the principles and practice of clinical research. Molecular medicine, genomics, and proteomics have opened vast opportunities for translation of basic science observations to the bedside through clinical research. As an introductory reference it gives clinical investigators in all fields an awareness of the tools required to ensure research protocols are well designed and comply with the rigorous regulatory requirements necessary to maximize the safety of research subjects. Complete with sections on the history of clinical research and ethics, copious figures and charts, and sample documents it serves as an excellent companion text for any course on clinical research and as a must-have reference for seasoned researchers.*Incorporates new chapters on Managing Conflicts of Interest in Human Subjects Research, Clinical Research from the Patient's Perspective, The Clinical Researcher and the Media, Data Management in Clinical Research, Evaluation of a Protocol Budget, Clinical Research from the Industry Perspective, and Genetics in Clinical Research *Addresses the vast opportunities for translation of basic science observations to the bedside through clinical research*Delves into data management and addresses how to collect data and use it for discovery*Contains valuable, up-to-date information on how to obtain funding from the federal government

From the early days of its recognized occurrence, AIDS has been per ceived as posing tremendous threats, burdens and challenges to human beings. Individuals, societies and, in a global point of view, mankind are affected by the effects of the HN infection, the nature and extent of which is still unclear in many ways. In the beginning only biomedical and epidemiological analyses of the problem were the top research priori ties, the former laden with great hopes that it may soon be possible to stop the spread of the disease and to overcome its physical impact. Yet it soon became clear that AIDS would be something to be reckoned and coped with on a long-term basis, making a thorough investigation of its impact absolutely mandatory. AIDS has serious economic consequences. Taken seriously, they can not be confined to predictions of costs intended to support the AIDS issue in the struggle for resources. Besides cost calculations - a method ologically tricky and wide-ranging topic in itself -and their application to cost-effectiveness and other analyses, economic issues include identify ing and assessing patterns of care, analyzing problems of financing, exploring impacts on markets other than health care, and modelling scenarios for future developments and strategies. At present, the eco nomic aspects of AIDS still constitute a very recent topic in European health economics and health systems research. Many projects are just about to start, and there must be a better exchange of information between research groups.

Much evidence suggests that the US does not achieve good value for its health care spending. This book provides a unique perspective on this problem by considering the economic, social, political, and ethical factors that contribute to it, and by seeking to show how experience can guide better policy making in the future.

This book presents the research results obtained by Grupo de Equidad en Salud (Health Equity Group), in relation to the development of an indicator of inequity in avoidable mortality, consisting of a methodology that allows knowing, in a consolidated way, the state of the inequality in avoidable mortality based on the variants included in the development of the indicator itself; also, an analysis of global and local data allows realistically understanding the dimension of the problem in both contexts. This book provides additional elements of analysis in order to assess the inadequate role of health systems in solving the most sensitive problems affecting vulnerable populations. On the other hand, conceptual elements around the issue of inequity, as well as the results of a systematic review of the literature related to the different ways of measuring disparities, gaps or inequities in health, are presented here to help the reader approach the development of new conceptual or measurement proposals. This book is intended to contribute to the understanding of the issue, and to encourage joint solutions to avoidable problems of high social cost.

The second edition of Difficult Decisions in Thoracic Surgery: An Evidence- Based Approach addresses the growing complexity of decision making in thoracic surgery. More than half of the clinical questions posed in this book are new, and of the questions that remain as holdovers from the previous edition, virtually all have been revised and updated. As new technology is introduced, physicians from nonsurgical specialties offer alternative and competing therapies for what was once the exclusive province of the thoracic surgeon. In addition, there is increasing knowledge regarding the efficacy of traditional thoracic surgical therapies. How to select among these varied and complex approaches is becoming increasingly difficult. Concise chapters are devoted to one or two specific questions, or decisions, in general thoracic surgery that are difficult or controversial. The authors identify relevant publications in their selected topics, grade the quality of the evidence offered by those reports, apply that knowledge to objective management recommendations in an idealized world, and then comment on how they personally use the information in their own clinical practices. The book is a valuable reference source for practicing surgeons, surgeons in training, and educators.

In this 2nd edition Petitti has added new material on cumulative meta-analysis and the exploration of heterogeneity, incorporated recommendations for standardizing the conduct of cost-effectiveness analysis, and updated the rest of the text

Written by renowned epidemiologists and public health experts, this unique text provides complete, concise coverage of epidemiology, biostatistics, preventive medicine, and public health in clear, easy-to-understand terms. One convenient volume delivers must-know content in four complex areas—information that's sure to be covered in today's classrooms and on USMLE exams—presented with a clinical focus and real-life medical examples throughout. Depth of coverage, concise writing style, outstanding online review questions, a clinical emphasis ... these features and more make Jekel's your go-to resource for learning, study, and review. - Focuses on clinical problem solving and decision making using epidemiologic concepts and examples. - Contains more clinical cases throughout, including global examples. - Offers expanded coverage of the impact of big data and precision medicine, as well as an updated and reorganized biostatistics section. - Features quick-reference boxes that showcase key concepts and calculations, and dynamic illustrations that facilitate learning using a highly visual approach. - Provides almost 300 multiple-choice chapter review questions and answers in print, with additional questions and more online at Student Consult. - Aligns content to board blueprints for the USMLE as well as the three specialties certified by the American Board of Preventive Medicine: Occupational Medicine, and Public Health & General Preventive Medicine—and is recommended by the ABPM as a top review source for its core specialty examination. - Enhanced eBook version included with purchase. Your enhanced eBook allows you to access all the text, figures, and references from the book on a variety of devices. - Evolve Instructor site, with an image and table bank as well as chapter overviews as PowerPoints, is available to instructors through their Elsevier sales rep or via request at: https://evolve.elsevier.com.