Metabolic syndrome (MetS) can be considered as a clustering of several risk factors such as obesity, hypertension, insulin resistance and dyslipidemia, which could lead to the development of diabetes and cardiovascular diseases (CVD). There are several underlying causes for MetS including overweight, physical inactivity and genetic factors. However, the underlying mechanisms that leads to MetS are still poorly understood. Therefore, the aim of this E-book is to provide a space where researchers holding different backgrounds could shed some light onto the pathophysiology of different risk factors involved in MetS, mostly from translational research worldwide.

Diabetes mellitus is a group of metabolic diseases in which a person has high blood sugar, either because the body does not produce enough insulin, or because cells do not respond to the insulin that is produced. This book is a comprehensive guide to the management of Type 2 diabetes mellitus, with a focus on associated disorders and comorbidities. Beginning with an explanation of hyperglycaemia, Type 2 diabetes, and pathophysiology, the following chapters cover associated cardiovascular, renal, oncological, and autoimmune system disorders. The book concludes with discussion on management of Type 2 diabetes in special situations such as during Ramadan and in patients with liver disease, and optimisation of risk factors. Key points Comprehensive guide to management of Type 2 diabetes mellitus Focus on associated disorders and comorbidities Discusses management of Type 2 diabetes during Ramadan and in patients with liver disease Includes clinical images and figures to enhance text

This volume represents an up-to-date overview on pre-Menopause and Menopause, with their respective clinical implications and therapies. The aim is to clarify possible doubts and clinical approaches to this particular period in a woman’s life and how to face it, both offering solutions to actual problems and focusing on the potential impact of preventive medicine in improving women’s health and quality of life. The volume is published within the International Society of Gynecological Endocrinology (ISGE) Series, and is based on the 2017 International School of Gynecological and Reproductive Endocrinology Winter Course. This book, covering a very wide range of topics with particular focus on fertility in pre- and peri-menopausal women, climacteric and menopausal symptoms, impact of PCOS on post-menopausal health, breast disease, surgical treatments and therapies, will be an invaluable tool for gynecologists, endocrinologists, and experts in women’s health.

This book presents the state of the art of type 2 diabetes genetics, from the process of genetic discovery to its interpretation and clinical application, and illustrates a model for other complex human phenotypes.The first section explores genome-wide association studies, the extension of this method to less accessible phenotypes and the arrival of next-generation sequencing. A further section goes beyond genetics to illustrate how other data sources can help interpret genetic data, such as leveraging population diversity, the correlation of genetic associations with physiological measurements, gene expression modulation, environmental factors and our microbial commensals. The third section describes advances in elucidating the complex path from association to function using in-depth sequencing and functional studies of the cellular and molecular effects of genes in the loci identified by genetics. The final section links our current understanding with clinically relevant questions, such as prediction, interactions with drugs or nutrients, and disease prevention, and paints a realistic but hopeful vision of the future. ​

Type 2 diabetes (T2D), also known as non-insulin-dependent diabetes mellitus (NIDDM), is a condition in which cells fail to respond to insulin properly. As the disease progresses, the body does not produce enough insulin. There are several classes of anti-diabetic medications available, including the oral agent metformin. This medication is recommended as first-line treatment for T2D, except for those patients with severe kidney or liver problems. This book discusses the molecular mechanism, pharmacokinetics, and uses of metformin, as well as presents information on adverse drug reactions, drug interactions, and the potential use of metformin in tuberculosis.

Diabetes Clinical Case Series – 2 is the second volume in a three-volume series on diabetes. The book provides a selection of cases reflecting the types of diabetes, related conditions and potential complications in different segments of the population. Divided into 20 chapters, the book features a range of topics, including stress-related diabetes, gestational diabetes, diabetes with renal problems, Cushing’s Syndrome and diabetes, Charcot Foot and Ankle, diabetic retinopathy, Werner Syndrome, and much more. Each chapter begins with a real-life case scenario, followed by guidance on its management, combining evidence-based medicine with the authors’ clinical experience, to provide an authoritative guide for endocrinologists. Key Points Second of three volumes in Diabetes Clinical Case Series 20 chapters featuring real cases and guidance on management diabetes in different segments of the population Authoritative guide combining evidence-based medicine and clinical experience Diabetes Clinical Case Series – 1 (9789352500321) published in 2016

This book presents state of the art knowledge on diabetes in stroke, covering both basic and clinical aspects in detail. The focus is in particular on two major areas: general knowledge of diabetes and diabetes from a stroke neurologist’s perspective. Readers will find up-to-date information on glucose metabolism, the pathophysiology of diabetes, the clinical significance of diabetes in stroke, the differential influence of diabetes on stroke mechanisms, principles of diabetes care, advances in treatment options, and clinical practice in the real world. The individual components of pathophysiology, management, and key issues are fully addressed with the aid of complementary illustrations that facilitate understanding of practical aspects and enable the reader to retrieve fundamental information quickly. The book is timely in bringing together within one volume the most important current knowledge on diabetes in stroke. It will be invaluable for stroke physicians, epidemiologists, and students seeking to acquire up-to-date knowledge.