Protein research is a frontier field in science. Proteins are widely distributed in plants and animals and are the principal constituents of the protoplasm of all cells, and consist essentially of combinations of a-amino acids in peptide linkages. Twenty different amino acids are commonly found in proteins, and serve as enzymes, structural elements, hormones, immunoglobulins, etc., and are involved throughout the body, and in photosynthesis. This book gathers new leading-edge research from throughout the world in this exciting and exploding field of research.

Protein research is a frontier field in science. Proteins are widely distributed in plants and animals and are the principal constituents of the protoplasm of all cells, and consist essentially of combinations of a-amino acids in peptide linkages. Twenty different amino acids are commonly found in proteins, and serve as enzymes, structural elements, hormones, immunoglobulins, etc., and are involved throughout the body, and in photosynthesis. This book gathers new leading-edge research from throughout the world in this exciting and exploding field of research.

In Protein Structure, Stability, and Folding, Kenneth P. Murphy and a panel of internationally recognized investigators describe some of the newest experimental and theoretical methods for investigating these critical events and processes. Among the techniques discussed are the many methods for calculating many of protein stability and dynamics from knowledge of the structure, and for performing molecular dynamics simulations of protein unfolding. New experimental approaches presented include the use of co-solvents, novel applications of hydrogen exchange techniques, temperature-jump methods for looking at folding events, and new strategies for mutagenesis experiments. Unique in its powerful combination of theory and practice, Protein Structure, Stability, and Folding offers protein and biophysical chemists the means to gain a more comprehensive understanding of some of this complex area by detailing many of the major techniques in use today.

ICSSD 2002 is the second in the series of International Conferences on Structural Stability and Dynamics, which provides a forum for the exchange of ideas and experiences in structural stability and dynamics among academics, engineers, scientists and applied mathematicians. Held in the modern and vibrant city of Singapore, ICSSD 2002 provides a peep at the areas which experts on structural stability and dynamics will be occupied with in the near future. From the technical sessions, it is evident that well-known structural stability and dynamic theories and the computational tools have evolved to an even more advanced stage. Many delegates from diverse lands have contributed to the ICSSD 2002 proceedings, along with the participation of colleagues from the First Asian Workshop on Meshfree Methods and the International Workshop on Recent Advances in Experiments and Computations on Modeling of Heterogeneous Systems. Forming a valuable source for future reference, the proceedings contain 153 papers OCo including 3 keynote papers and 23 invited papers OCo contributed by authors from all over the world who are working in advanced multi-disciplinary areas of research in engineering. All these papers are peer-reviewed, with excellent quality, and cover the topics of structural stability, structural dynamics, computational methods, wave propagation, nonlinear analysis, failure analysis, inverse problems, non-destructive evaluation, smart materials and structures, vibration control and seismic responses.The major features of the book are summarized as follows: a total of 153 papers are included with many of them presenting fresh ideas and new areas of research; all papers have been peer-reviewed and are grouped into sections for easy reference; wide coverage of research areas is provided and yet there is good linkage with the central topic of structural stability and dynamics; the methods discussed include those that are theoretical, analytical, computational, artificial, evolutional and experimental; the applications range from civil to mechanical to geo-mechanical engineering, and even to bioengineering."

ICSSD 2002 is the second in the series of International Conferences on Structural Stability and Dynamics, which provides a forum for the exchange of ideas and experiences in structural stability and dynamics among academics, engineers, scientists and applied mathematicians. Held in the modern and vibrant city of Singapore, ICSSD 2002 provides a peep at the areas which experts on structural stability and dynamics will be occupied with in the near future. From the technical sessions, it is evident that well-known structural stability and dynamic theories and the computational tools have evolved to an even more advanced stage. Many delegates from diverse lands have contributed to the ICSSD 2002 proceedings, along with the participation of colleagues from the First Asian Workshop on Meshfree Methods and the International Workshop on Recent Advances in Experiments and Computations on Modeling of Heterogeneous Systems. Forming a valuable source for future reference, the proceedings contain 153 papers — including 3 keynote papers and 23 invited papers — contributed by authors from all over the world who are working in advanced multi-disciplinary areas of research in engineering. All these papers are peer-reviewed, with excellent quality, and cover the topics of structural stability, structural dynamics, computational methods, wave propagation, nonlinear analysis, failure analysis, inverse problems, non-destructive evaluation, smart materials and structures, vibration control and seismic responses.The major features of the book are summarized as follows: a total of 153 papers are included with many of them presenting fresh ideas and new areas of research; all papers have been peer-reviewed and are grouped into sections for easy reference; wide coverage of research areas is provided and yet there is good linkage with the central topic of structural stability and dynamics; the methods discussed include those that are theoretical, analytical, computational, artificial, evolutional and experimental; the applications range from civil to mechanical to geo-mechanical engineering, and even to bioengineering.

In this era of biotechnology there have been many books covering the fundamentals of recombinant DNA technology and protein chemistry. However, not many sources are available for the pharmaceutical develop ment scientist and other personnel responsible for the commercialization of the finished dosage forms of these new biopharmaceuticals and other products from biotechnology. This text will help to fill this gap. Once active biopharmaceutical molecules are candidates for clinical trial investigation and subsequent commercialization, a number of other activities must take place while research and development on these molecules continues. The active ingredient itself must be formulated into a finished dosage form that can be conveniently used by health care professionals and patients. Properties of the biopharmaceutical molecule must be clearly understood so that the appropriate finished product formulation can be developed. Finished product formulation development includes not only the chemical formulation, but also the packaging system, the manufacturing process, and appropriate control strategies to assure such good manufacturing practice attributes as safety, identity, strength, purity, and quality.

This book describes recent important advancements in protein folding dynamics and stability research, as well as explaining fundamentals and examining potential methodological approaches in protein science. In vitro, in silico, and in vivo method based research of how the stability and folding of proteins help regulate the cellular dynamics and impact cell function that are crucial in explaining various physiological and pathological processes. This book offers a comprehensive coverage on various techniques and related recent developments in the experimental and computational methods of protein folding, dynamics, and stability studies. The book is also structured in such a way as to summarize the latest developments in the fiddle and key concepts to ensure that readers can understand advanced concepts as well as the fundamental big picture. And most of all, fresh insights are provided into the convergence of protein science and technology. Protein Folding Dynamics and Stability is an ideal guide to the field that will be of value for all levels of researchers and advanced graduate students with training in biochemical laboratory research.

This volume provides an overview of the development and scope of molecular biophysics and in-depth discussions of the major experimental methods that enable biological macromolecules to be studied at atomic resolution. It also reviews the physical chemical concepts that are needed to interpret the experimental results and to understand how the structure, dynamics, and physical properties of biological macromolecules enable them to perform their biological functions. Reviews of research on three disparate biomolecular machines—DNA helicases, ATP synthases, and myosin--illustrate how the combination of theory and experiment leads to new insights and new questions.

This book gathers the proceedings of the Seventh International Conference on Computational Science and Technology (ICCST 2021), held in Labuan, Malaysia, on 28–29 August 2021. The respective contributions offer practitioners and researchers a range of new computational techniques and solutions, identify emerging issues, and outline future research directions, while also showing them how to apply the latest large-scale, high-performance computational methods.