Modeling and Control of Drug Delivery Systems provides comprehensive coverage of various drug delivery and targeting systems and their state-of-the-art related works, ranging from theory to real-world deployment and future perspectives. Various drug delivery and targeting systems have been developed to minimize drug degradation and adverse effect and increase drug bioavailability. Site-specific drug delivery may be either an active and/or passive process. Improving delivery techniques that minimize toxicity and increase efficacy offer significant potential benefits to patients and open up new markets for pharmaceutical companies. This book will attract many researchers working in DDS field as it provides an essential source of information for pharmaceutical scientists and pharmacologists working in academia as well as in the industry. In addition, it has useful information for pharmaceutical physicians and scientists in many disciplines involved in developing DDS, such as chemical engineering, biomedical engineering, protein engineering, gene therapy. - Presents some of the latest innovations of approaches to DDS from dynamic controlled drug delivery, modeling, system analysis, optimization, control and monitoring - Provides a unique, recent and comprehensive reference on DDS with the focus on cutting-edge technologies and the latest research trends in the area - Covers the most recent works, in particular, the challenging areas related to modeling and control techniques applied to DDS

Novel Drug Delivery Systems in the Management of CNS Disorders offers a comprehensive source of information on delivering drugs to the central nervous system to treat various diseases and conditions. The book covers a wide range of CNS disorders, including epilepsy, Parkinson's, Alzheimer's, Huntington's, multiple sclerosis, schizophrenia, cerebral palsy, autism, ALS, and others. The book begins by presenting the foundations of drug delivery to the brain and addressing the associated challenges. It then delves into clinical trials and explores the future potential of the presented technologies. This reference is designed for drug delivery researchers in academia and corporations, providing them with the essential knowledge about overcoming the Brain-Blood Barrier and achieving targeted drug delivery to the central nervous system. - Consolidates current state of the art research into a single book volume - Presents the challenges of drug delivery to the CNS in a comprehensive way - Covers the most relevant CNS conditions and diseases - Provides future perspectives and the most active research areas in this fast-moving field

This book reviews collagen-based biomaterials that have been applied broadly to tissue engineering and local drug delivery applications and lays out a landscape for developing a multifunctional biograft material from collagen polymers. The book also discusses current shortcomings in collagen based drug delivery opportunities, including poor mechanical properties, rapid proteolytic degradation, and cursory control over physical properties and molecular release profiles. Finally, a review of application of the collagen biograft materials for promoting neovascularization and tissue regeneration is presented, using examples of established in-vivo chicken egg chorioallantoic membrane (CAM) model. Use of heparin for affinity-based vascular endothelial growth factor (VEGF) retention in collagen constructs is also discussed for promoting neovascularization. Reviews state-of-the-art strategies for drug incorporation and retention in collagen​; Covers collagen based material applications for improving vascularization and tissue regeneration; Illustrates how to tailor collagen architecture for soft tissue engineering and controlled drug delivery.

Enables readers to apply process dynamics and control theory to solve bioprocess and drug delivery problems The control of biological and drug delivery systems is critical to the health of millions of people worldwide. As a result, researchers in systems biology and drug delivery rely on process dynamics and control theory to build our knowledge of cell behavior and to develop more effective therapeutics, controlled release devices, and drug administration protocols to manage disease. Written by a leading expert and educator in the field, this text helps readers develop a deep understanding of process dynamics and control theory in order to analyze and solve a broad range of problems in bioprocess and drug delivery systems. For example, readers will learn how stability criteria can be used to gain new insights into the regulation of biological pathways and lung mechanics. They'll also learn how the concept of a time constant is used to capture the dynamics of diffusive processes. Readers will also master such topics as external disturbances, transfer functions, and input/output models with the support of the author's clear explanations, as well as: Detailed examples from the biological sciences and novel drug delivery technologies 160 end-of-chapter problems with step-by-step solutions Demonstrations of how computational software such as MATLAB and Mathematica solve complex drug delivery problems Control of Biological and Drug-Delivery Systems for Chemical, Biomedical, and Pharmaceutical Engineering is written primarily for undergraduate chemical and biomedical engineering students; however, it is also recommended for students and researchers in pharmaceutical engineering, process control, and systems biology. All readers will gain a new perspective on process dynamics and control theory that will enable them to develop new and better technologies and therapeutics to treat human disease.

Hydrogels are crosslinked, macromolecular polymeric materials arranged in a three-dimensional network, which can absorb and retain large amounts of water. Hydrogels are commonly used in clinical practice and experimental medicine for a wide range of applications, including drug delivery, tissue engineering and regenerative medicine, diagnostics, cellular immobilization, separation of biomolecules or cells, and barrier materials to regulate biological adhesions. This book elucidates the underlying concepts and emerging applications of hydrogels and will provide key case studies and critical analysis of the existing research.

A Handbook of Artificial Intelligence in Drug Delivery explores the use of Artificial Intelligence (AI) in drug delivery strategies. The book covers pharmaceutical AI and drug discovery challenges, Artificial Intelligence tools for drug research, AI enabled intelligent drug delivery systems and next generation novel therapeutics, broad utility of AI for designing novel micro/nanosystems for drug delivery, AI driven personalized medicine and Gene therapy, 3D Organ printing and tissue engineering, Advanced nanosystems based on AI principles (nanorobots, nanomachines), opportunities and challenges using artificial intelligence in ADME/Tox in drug development, commercialization and regulatory perspectives, ethics in AI, and more. This book will be useful to academic and industrial researchers interested in drug delivery, chemical biology, computational chemistry, medicinal chemistry and bioinformatics. The massive time and costs investments in drug research and development necessitate application of more innovative techniques and smart strategies. - Focuses on the use of Artificial Intelligence in drug delivery strategies and future impacts - Provides insights into how artificial intelligence can be effectively used for the development of advanced drug delivery systems - Written by experts in the field of advanced drug delivery systems and digital health

This book focusses on the development of biomedical membranes and their applications for (bio)artificial organs. It covers the state of art and main challenges for applying synthetic membranes in these organs. It also highlights the importance of accomplishing an integration of engineering with biology and medicine to understand and manage the scientific, industrial, clinical and ethical aspects of these organs.The compendium consists of 11 chapters, written by world renowned experts in the fields of membrane technology, biomaterials science and technology, cell biology, medicine and engineering. Every chapter describes the clinical needs and the materials, membranes, and concepts required for the successful development of the (bio)artificial organs.This text is suitable for undergraduate and graduate students in biomedical engineering, materials science and membrane science and technology, as well as, for professionals and researchers working in these fields.

A reference is needed that addresses the recent progress in aspects of PK/PD methods and developments of nanoparticles for novel drug delivery systems. No other consolidated published reference discusses the PK/PD study of nanoparticle drug delivery systems. This book discusses the advantages of nanoparticle drug delivery systems (NPDDS) in enhancing the pharmacokinetics of many drugs that are not easily metabolized or that obtain the desired therapeutic effect with minimum toxicity. The authors provide an overview of biodistribution with a focus on polymer and lipid nanoparticles. This thorough reference is divided into three parts: Modelling, Specific carries and their potential to treat specific diseases.

This four-volume handbook gives a state-of-the-art overview of porous materials, from synthesis and characterization and simulation all the way to manufacturing and industrial applications. The editors, coming from academia and industry, are known for their didactic skills as well as their technical expertise. Coordinating the efforts of 37 expert authors in 14 chapters, they construct the story of porous carbons, ceramics, zeolites and polymers from varied viewpoints: surface and colloidal science, materials science, chemical engineering, and energy engineering. Volumes 1 and 2 cover the fundamentals of preparation, characterisation, and simulation of porous materials. Working from the fundamentals all the way to the practicalities of industrial production processes, the subjects include hierarchical materials, in situ and operando characterisation using NMR, X-Ray scattering and tomography, state-of-the-art molecular simulations of adsorption and diffusion in crystalline nanoporous materials, as well as the emerging areas of bio-artificing and drug delivery. Volume 3 focuses on porous materials in industrial separation applications, including adsorption separation, membrane separation, and osmotic distillation. Finally, and highly relevant to tomorrow's energy challenges, Volume 4 explains the energy engineering aspects of applying porous materials in supercapacitors, fuel cells, batteries, electrolysers and sub-surface energy applications.The text contains many high-quality colourful illustrations and examples, as well as thousands of up-to-date references to peer-reviewed articles, reports and websites for further reading. This comprehensive and well-written handbook is a must-have reference for universities, research groups and companies working with porous materials.Related Link(s)