The idea of preparing this volume originated from the ever increasing importance of computational modelling of complex problems in medicine. Considerable advances have been made in this area as demonstrated by the continued success of the International Conference on Modelling in Medicine and Biology organised by the Wessex Institute of Technology.The work reported at those meetings and the research carried out at the Wessex Institute of Technology indicated the increasing interaction and collaboration between medical and engineering scientists. Advances presented at these conferences are now being used in practice for a wide range of medical and surgical applications.The considerable improvements and evolution of the field has led to some of the best scientists, who have participated in our conferences, to write an article on their most recent research. This has led to thirteen outstanding articles published in this volume which encompass important areas of biomedical modelling.

Aimed at postgraduate students in a variety of biology-related disciplines, this volume presents a collection of mathematical and computational single-cell-based models and their application. The main sections cover four general model groupings: hybrid cellular automata, cellular potts, lattice-free cells, and viscoelastic cells. Each section is introduced by a discussion of the applicability of the particular modelling approach and its advantages and disadvantages, which will make the book suitable for students starting research in mathematical biology as well as scientists modelling multicellular processes.

Thanks to recent advancements, optimization is now recognized as a crucial component in research and decision-making across a number of fields. Through optimization, scientists have made tremendous advances in cancer treatment planning, disease control, and drug development, as well as in sequencing DNA, and identifying protein structures. Op

Mathematical and computational modeling approaches in biological and medical research are experiencing rapid growth globally. This Special Issue Book intends to scratch the surface of this exciting phenomenon. The subject areas covered involve general mathematical methods and their applications in biology and medicine, with an emphasis on work related to mathematical and computational modeling of the complex dynamics observed in biological and medical research. Fourteen rigorously reviewed papers were included in this Special Issue. These papers cover several timely topics relating to classical population biology, fundamental biology, and modern medicine. While the authors of these papers dealt with very different modeling questions, they were all motivated by specific applications in biology and medicine and employed innovative mathematical and computational methods to study the complex dynamics of their models. We hope that these papers detail case studies that will inspire many additional mathematical modeling efforts in biology and medicine

If a basic advance in physics has any practical applications, among the first are those in biology and medicine. This is quite striking when one considers even such unlikely things as the Mössbauer effect and X rays. Within a very short period of their discovery, they had welI-formulated biological and medical applications. The discovery of the laser is no exception. AIthough the theoretical basis for it was established in 1917 by Einstein, the techniques and materials necessary for building a laser were not then available. The laser has revitalized everything connected with optics. It has furnished the experimenter and the teacher with a pseudo-point source. It has translated many a theoretical experiment into one that can be realized practicalIy. The highly monochromatic and coherent aspects of the light, in addition to the high power levels that can be attained, add greatly to the usefulness in this regard. The industrial applictions range from punching holes in baby bottle nipples to a surveyor's instrument of such accuracy that it can plot tlie position of the moon relative to the earth within a few feet. Many years of very informal meeting on the subject of lasers in medicine and biology have been sponsored by the Gordon Research Conferences. The present book is an outgrowth of the discussions that took place at these meetings, aIthough it is in no sense a symposium report.

Written for biomedical professionals and hospital practitioners interested in creating their own programs, Perl Programming for Medicine and Biology, discusses and reviews biomedical data resources, data standards, data organization, medicolegal and ethical conduct for data miners, and grants-related data sharing responsibilities. It teaches readers the basic Perl programming skills necessary for collecting, analyzing, and distributing biomedical data and provides solutions to in-depth problems that face researchers and healthcare professionals. Non-technical "Background" sections open each chapter to help non-programmers easily comprehend programming procedures. Explanations are provided for the biomedical issues underlying the Perl scripts that follow, and examples of real-world implementation are provided. Perl Programming for Medicine and Biology will show you how to transform, merge, and examine large and complex databases with ease.

An innovative introduction to ecology and evolution This unique textbook introduces undergraduate students to quantitative models and methods in ecology, behavioral ecology, evolutionary biology, and conservation. It explores the core concepts shared by these related fields using tools and practical skills such as experimental design, generating phylogenies, basic statistical inference, and persuasive grant writing. And contributors use examples from their own cutting-edge research, providing diverse views to engage students and broaden their understanding. This is the only textbook on the subject featuring a collaborative "active learning" approach that emphasizes hands-on learning. Every chapter has exercises that enable students to work directly with the material at their own pace and in small groups. Each problem includes data presented in a rich array of formats, which students use to answer questions that illustrate patterns, principles, and methods. Topics range from Hardy-Weinberg equilibrium and population effective size to optimal foraging and indices of biodiversity. The book also includes a comprehensive glossary. In addition to the editors, the contributors are James Beck, Cawas Behram Engineer, John Gaskin, Luke Harmon, Jon Hess, Jason Kolbe, Kenneth H. Kozak, Robert J. Robertson, Emily Silverman, Beth Sparks-Jackson, and Anton Weisstein. Provides experience with hypothesis testing, experimental design, and scientific reasoning Covers core quantitative models and methods in ecology, behavioral ecology, evolutionary biology, and conservation Turns "discussion sections" into "thinking labs" Professors: A supplementary Instructor's Manual is available for this book. It is restricted to teachers using the text in courses. For information on how to obtain a copy, refer to: http://press.princeton.edu/class_use/solutions.html