The monograph discusses models of synthetic protocells, which are cell-like structures obtained from non-living matter endowed with some rudimentary kind of metabolism and genetics, but much simpler than biological cells. They should grow and proliferate, generating offsprings that resemble in some way the parent protocells with some variation, so that selection may take place. Sustainable protocell populations have not yet been obtained experimentally and mathematical models are therefore extremely important to address key questions concerning their synthesis and behavior. Different protocell “architectures” have been proposed and high-level abstract models like those that are presented in this book are particularly relevant to gain a better understanding of the different properites. These models are able to treat all the major dynamical phenomena in a unified framework, so they can be seen as “virtual laboratories” for protocell research. Particular attention is paid to the problem of synchronization of the fission rate of the whole protocell and the duplication rate of its "protogenetic" material, which is shown to be an emergent property that spontaneously develops in successive generations. The book is of interest for a broad range of scientists working in soft matter physics, chemistry and biology, interested in the role protocells may play on the development of new technologies with medical, environmental and industrial applications as well as scientists interested in the origin of life.

This book constitutes the revised selected papers of the 12th Italian Workshop on Advances in Artificial Life, Evolutionary Computation, WIVACE 2017, held in Venice, Italy, in September 2017.The 23 full papers presented were thoroughly reviewed and selected from 33 submissions. They cover the following topics: physical-chemical phenomena; biological systems; economy and society; complexity; optimization.

The first comprehensive general resource on state-of-the-art protocell research, describing current approaches to making new forms of life from scratch in the laboratory. Protocells offers a comprehensive resource on current attempts to create simple forms of life from scratch in the laboratory. These minimal versions of cells, known as protocells, are entities with lifelike properties created from nonliving materials, and the book provides in-depth investigations of processes at the interface between nonliving and living matter. Chapters by experts in the field put this state-of-the-art research in the context of theory, laboratory work, and computer simulations on the components and properties of protocells. The book also provides perspectives on research in related areas and such broader societal issues as commercial applications and ethical considerations. The book covers all major scientific approaches to creating minimal life, both in the laboratory and in simulation. It emphasizes the bottom-up view of physicists, chemists, and material scientists but also includes the molecular biologists' top-down approach and the origin-of-life perspective. The capacity to engineer living technology could have an enormous socioeconomic impact and could bring both good and ill. Protocells promises to be the essential reference for research on bottom-up assembly of life and living technology for years to come. It is written to be both resource and inspiration for scientists working in this exciting and important field and a definitive text for the interested layman.

This book constitutes the refereed proceedings of the 16th Italian Workshop on Artificial Life and Evolutionary Computation, WIVACE 2022, held in Gaeta, Italy, during September 14–16, 2022. The 21 full papers and 3 short papers included in this book were carefully reviewed and selected from 45 submissions. They were organized in topical sections as follows: answer set programming; networks and complex systems, metaheuristics, robotics, and machine learning Chapters 7, 8, and 9 are available open access under a Creative Commons Attribution 4.0 International License via link.springer.com.

Conflicting Models for the Origin of Life Conflicting Models for the Origin of Life provides a forum to compare and contrast the many hypotheses that have been put forward to explain the origin of life. There is a revolution brewing in the field of Origin of Life: in the process of trying to figure out how Life started, many researchers believe there is an impending second creation of life, not necessarily biological. Up-to-date understanding is needed to prepare us for the technological, and societal changes it would bring. Schrodinger’s 1944 “What is life?” included the insight of an information carrier, which inspired the discovery of the structure of DNA. In “Conflicting Models of the Origin of Life” a selection of the world’s experts are brought together to cover different aspects of the research: from progress towards synthetic life – artificial cells and sub-cellular components, to new definitions of life and the unexpected places life could (have) emerge(d). Chapters also cover fundamental questions of how memory could emerge from memoryless processes, and how we can tell if a molecule may have emerged from life. Similarly, cutting-edge research discusses plausible reactions for the emergence of life both on Earth and on exoplanets. Additional perspectives from geologists, philosophers and even roboticists thinking about the origin of life round out this volume. The text is a state-of-the-art snapshot of the latest developments on the emergence of life, to be used both in graduate classes and by citizen scientists. Audience Researchers in any area of astrobiology, as well as others interested in the origins of life, will find a modern and current review of the field and the current debates and obstacles. This book will clearly illustrate the current state-of-the-art and engage the imagination and creativity of experts across many disciplines.

This book surveys the models for the origin of life and presents a new model starting with shaped droplets and ending with life as polygonal Archaea; it collects the most published micrographs of Archaea (discovered only in 1977), which support this conclusion, and thus provides the first visual survey of Archaea. Origin of Life via Archaea’s purpose is to add a new hypothesis on what are called “shaped droplets”, as the starting point, for flat, polygonal Archaea, supporting the Vesicles First hypothesis. The book contains over 6000 distinct references and micrographs of 440 extant species of Archaea, 41% of which exhibit polygonal phenotypes. It surveys the intellectual battleground of the many ideas of the origin of life on earth, chemical equilibrium, autocatalysis, and biotic polymers. This book contains 17 chapters, some coauthored, on a wide range of topics on the origin of life, including Archaea’s origin, patterns, and species. It shows how various aspects of the origin of life may have occurred at chemical equilibrium, not requiring an energy source, contrary to the general assumption. For the reader’s value, its compendium of Archaea micrographs might also serve many other interesting questions about Archaea. One chapter presents a theory for the shape of flat, polygonal Archaea in terms of the energetics at the surface, edges and corners of the S-layer. Another shows how membrane peptides may have originated. The book also includes a large table of most extant Archaea, that is searchable in the electronic version. It ends with a chapter on problems needing further research. Audience This book will be used by astrobiologists, origin of life biologists, physicists of small systems, geologists, biochemists, theoretical and vesicle chemists.

This book constitutes the revised selected papers of the 9th Italian Workshop on Advances in Artificial Life and Evolutionary Computation held in Vietri sul Mare, Italy, in May 2014, in conjunction with the 24th Italian Workshop on Neural Networks, WIRN 2014. The 16 papers presented have been thoroughly reviewed and selected from 40 submissions. They cover the following topics: artificial neural networks; fuzzy inference systems; rough set; approximate reasoning; and optimization methods such as evolutionary computation, swarm intelligence, particle swarm optimization.

Throughout the ages architects have attempted to capture the essence of living systems as design inspiration. However, practitioners of the built environment have had to deal with a fundamental split between the artificial urban landscape and nature owing to a technological 'gap' that means architects have been unable to make effective use of biological systems in urban environments. Protocell Architecture is an edition of AD that shows for the first time that contemporary architects can create and construct architectures that are bottom up, synthetically biological, green and have no recourse to shallow bio-mimicry. In the next few decades, synthetic biology is set to have as much, if not more, impact on architecture as cyberspace and the digital. The key to these amazing architectural innovations is the Protocell.