The biopharmaceutical market has come along way since 1982 when the first biopharmaceutical product, recombinant human insulin, was launched. Over 120 such products are currently being marketed around the world including nine blockbuster drugs. The global market for biopharmaceuticals, which is currently valued at US$41 billion, has been growing at an impressive compound annual growth rate of 21% over the previous five years. With over one third of all pipe-line products in active development are biopharmaceuticals, this segment is set to continue outperforming the total pharmaceutical market and could easily reach US$100 billion by the end of this decade.

Systematically addressing the key steps and challenges along the biopharmaceutical production process, this two volume handbook provides key knowledge for medium to large scale producers of biopharmaceuticals. The volumes are divided into six major parts, on upstream technologies, protein recovery, process development, analytical technologies, quality control, and an outlook section that addresses new and emerging technologies, such as single-use processes and integrated process design. With contributions by some 40 experts from academia, as well as small and large biopharmaceutical companies, this unique handbook is full of valuable first-hand knowledge on how to produce biopharmaceuticals in a cost-effective and quality-controlled manner.

This collection of high-profile contributions provides a unique insight into the development of novel, successful biopharmaceuticals. Outstanding authors, including Nobel laureate Robert Huber as well as prominent company researchers and CEOs, present valuable insider knowledge, limiting their scope to those procedures and developments with proven potential for the biotechnology industry. They cover all relevant aspects, from the establishment of biotechnology parks, the development of successful compounds and the implementation of efficient manufacturing processes, right up to the establishment of advanced delivery routes.

Since the publication of the first edition in 2000, there has been an explosive growth of literature in biopharmaceutical research and development of new medicines. This encyclopedia (1) provides a comprehensive and unified presentation of designs and analyses used at different stages of the drug development process, (2) gives a well-balanced summary of current regulatory requirements, and (3) describes recently developed statistical methods in the pharmaceutical sciences. Features of the Fourth Edition: 1. 78 new and revised entries have been added for a total of 308 chapters and a fourth volume has been added to encompass the increased number of chapters. 2. Revised and updated entries reflect changes and recent developments in regulatory requirements for the drug review/approval process and statistical designs and methodologies. 3. Additional topics include multiple-stage adaptive trial design in clinical research, translational medicine, design and analysis of biosimilar drug development, big data analytics, and real world evidence for clinical research and development. 4. A table of contents organized by stages of biopharmaceutical development provides easy access to relevant topics. About the Editor: Shein-Chung Chow, Ph.D. is currently an Associate Director, Office of Biostatistics, U.S. Food and Drug Administration (FDA). Dr. Chow is an Adjunct Professor at Duke University School of Medicine, as well as Adjunct Professor at Duke-NUS, Singapore and North Carolina State University. Dr. Chow is the Editor-in-Chief of the Journal of Biopharmaceutical Statistics and the Chapman & Hall/CRC Biostatistics Book Series and the author of 28 books and over 300 methodology papers. He was elected Fellow of the American Statistical Association in 1995.

This new edition brings you up-to-date on the role of pharmaceutics and its future paradigms in the design of medicines. Contributions from over 30 international thought leaders cover the core disciplines of pharmaceutics and the impact of biotechnology, gene therapy, and cell therapy on current findings. Modern Pharmaceutics helps you stay current

Biotechnology represents a major area of research focus, and many universities are developing academic programs in the field. This guide to biomanufacturing contains carefully selected articles from Wiley's Encyclopedia of Industrial Biotechnology, Bioprocess, Bioseparation, and Cell Technology as well as new articles (80 in all,) and features the same breadth and quality of coverage and clarity of presentation found in the original. For instructors, advanced students, and those involved in regulatory compliance, this two-volume desk reference offers an accessible and comprehensive resource.

All CFA® Program exams through November 2021 will reflect the 2020 curriculum. Purchase your copy and begin studying for Level II now! The CFA® Program Curriculum 2020 Level II Box Set provides candidates and other motivated investment professionals with the official curriculum tested on the Level II CFA exam. This set includes practical instruction on the 10 core topics covered in the Candidate Body of Knowledge (CBOK) to prepare readers for their 2020 or 2021 Level II exam windows. Beyond the fundamentals, this set also offers expert guidance on how the CBOK is applied in practice. The Level II CFA® Program Curriculum focuses on complex analysis and asset valuation; it is designed to help candidates use essential investment concepts in real-world situations analysts encounter in the field. Topics explored in this box set include ethical and professional standards, quantitative analysis, economics, financial reporting and analysis, corporate finance, equities, fixed income, derivatives, alternative investments, and portfolio management. Visuals like charts, graphs, figures, and diagrams illustrate complex material covered on the Level II exam, and practice questions with answers help you understand your study progress while reinforcing important content. The CFA® Program Curriculum 2020 Level II Box Set builds from the foundational investment skills covered in Level I. This set helps you: Incorporate analysis skills into case evaluations Master complex calculations and quantitative techniques Understand the international standards used for valuation and analysis Gauge your skills and understanding against each Learning Outcome Statement Perfect for anyone considering the CFA® designation or currently preparing for a 2021 exam window, the 2020 Level II Box Set is a must-have resource for applying the skills required to become a Chartered Financial Analyst®.

Master the practical aspects of the CFA Program curriculum with expert instruction for the 2019 exam The same official curricula that CFA Program candidates receive with program registration is now publicly available for purchase. CFA Program Curriculum 2019 Level II, Volumes 1-6 provides the complete Level II curriculum for the 2019 exam, with practical instruction on the Candidate Body of Knowledge (CBOK) and how it is applied, including expert guidance on incorporating concepts into practice. Level II focuses on complex analysis with an emphasis on asset valuation, and is designed to help you use investment concepts appropriately in situations analysts commonly face. Coverage includes ethical and professional standards, quantitative analysis, economics, financial reporting and analysis, corporate finance, equities, fixed income, derivatives, alternative investments, and portfolio management organized into individual study sessions with clearly defined Learning Outcome Statements. Charts, graphs, figures, diagrams, and financial statements illustrate complex concepts to facilitate retention, and practice questions with answers allow you to gauge your understanding while reinforcing important concepts. While Level I introduced you to basic foundational investment skills, Level II requires more complex techniques and a strong grasp of valuation methods. This set dives deep into practical application, explaining complex topics to help you understand and retain critical concepts and processes. Incorporate analysis skills into case evaluations Master complex calculations and quantitative techniques Understand the international standards used for valuation and analysis Gauge your skills and understanding against each Learning Outcome Statement CFA Institute promotes the highest standards of ethics, education, and professional excellence among investment professionals. The CFA Program curriculum guides you through the breadth of knowledge required to uphold these standards. The three levels of the program build on each other. Level I provides foundational knowledge and teaches the use of investment tools; Level II focuses on application of concepts and analysis, particularly in the valuation of assets; and Level III builds toward synthesis across topics with an emphasis on portfolio management.

Filtration and Purification in the Biopharmaceutical Industry, First Edition greatly expands its focus with extensive new material on the critical role of purification and the significant advances in filtration science and technology. This new edition provides state-of-the-science information on all aspects of filtration and purification, in

This book provides a summarized information related to the global herbal drug market and its regulations, ethnopharmacology of traditional crude drugs, isolation of phytopharmaceuticals, phytochemistry, standardization, and quality assessment of crude drugs. Natural products science has constantly been developing with comprehensive data contemplating different parts of natural drugs, such as global trade, quality control and regulatory concerns, traditional medicine systems, production and utilization of drugs, and utilization of medicinal and aromatic plants. This broad information about crude drugs gives rise to a subject that is now recognized as advance natural products science. By contemplating all of this thorough knowledge of the areas, this book is intended to provide considerably to the natural products science. The area of natural products science involves a broad range of topics, such as the pharmacognostical, phytochemical, and ethno-pharmacological aspects of crude drugs. Each chapter gives a sufficient understanding to academicians and researchers in the respective topic. This book includes 40 illustrations and descriptions of roughly 80 medicinal plants used for herbal medicine. The book is an imperative source for all researchers, academicians, students, and those interested in natural products science. FEATURES Includes advance knowledge and detailed developments in natural products science Discusses the most important phytopharmaceuticals used in the pharmaceutical industry Explores the analysis and classification of novel plant-based medicinal compounds Includes standardization, quality control, and global trade of natural products Gives a deep understanding related to recent advances in herbal medicines to treat various ailments Discusses national and WHO regulations and policies related to herbal medicines Covers the complete profile of some important traditional medicinal plants, especially their historical background, biology, and chemistry