Transfer RNAs (tRNAs) are one of the classical non-coding RNAs whose lengths are approximately 70–100 bases. The secondary structure of tRNAs can be represented as the cloverleaf with 4 stems, and the three dimensional structure as an “L” shape. Historically, the basic function of tRNA as an essential component of translation was established in 1960s, i.e., each tRNA is charged with a target amino acid and these are delivered to the ribosome during protein synthesis. However, recent data suggests that the role of tRNA in cellular regulation goes beyond this paradigm. In most Archaea and Eukarya, precursor tRNAs are often interrupted by a short intron inserted strictly between the first and second nucleotide downstream of the anticodon, known as canonical nucleotide position (37/38). Recently, a number of reports describe novel aspects of tRNAs in terms of gene diversity, for example, several types of disrupted tRNA genes have been reported in the Archaea and primitive Eukarya, including multiple-intron-containing tRNA genes, split tRNA genes, and permuted tRNA genes. Our understanding of the enzymes involved in tRNA functions (e.g., aminoacyl-tRNA synthetase, tRNA splicing endonuclease, tRNA ligase) has deepened. Moreover, it is well known that tRNA possesses many types of base modifications whose enzymatic regulations remain to be fully elucidated. It was reported that impaired tRNA nuclear-cytoplasmic export links DNA damage and cell-cycle checkpoint. Furthermore, a variety of additional functions of tRNA, beyond its translation of the genetic code, have emerged rapidly. For instance, tRNA cleavage is a conserved part of the responses to a variety of stresses in eukaryotic cells. Age-associated or tissue-specific tRNA fragmentation has also been observed. Several papers suggested that some of these tRNA fragments might be involve in the cellular RNA interference (RNAi) system. These exciting data, have lead to this call for a Research Topic, that plans to revisit and summarize the molecular biology of tRNA. Beyond the topics outlined above, we have highlighted recent developments in bioinformatics tools and databases for tRNA analyses.

With a Foreword by Sydney Brenner (Nobel laureate in Physiology or Medicine, 2002)This biography details the life of Paul Berg (Emeritus Professor at Stanford University), tracing Berg's life from birth, in 1926, to the present, with special emphasis on his enormous scientific contributions, including being the first to develop technology that led to gene cloning science. In 1980, Berg received a Nobel Prize in chemistry for this work.In addition to his contributions in the research laboratory, Berg orchestrated and oversaw a historic meeting at Asilomar, California that centered on a threatening controversy surrounding the perception by some of the harmful potential of recombinant DNA technology. This meeting did much to forestall this controversy and to put in place the regulation of recombinant DNA work, thus putting fears to rest.The recombinant DNA controversy was a historic outcome of the discovery of gene cloning. Notably, it represented a paramount example of scientific foresight and due diligence by the scientific community, rather than by regulatory entities in the United States and many other countries. The ultimate acceptance of gene/DNA cloning led to a new era of modern biology that thrives to the present.This book is aimed primarily at scientists and those in training. The book strives to simply provide information for the general reader, but is not specifically tailored for a general reading audience.While many books cover the recombinant DNA controversy, none have satisfactorily addressed this historic period and are often contradictory about the many who's, where's, and why's involved. Additionally, the great majority of these were written by non-scientists. This biography of Paul Berg provides access to numerous archived letters and documents at Stanford University not previously addressed, and to the chronology of events as recalled and documented by him, as well as other key personalities, many of whom were interviewed.

Based on the Annual Symposium of the Jean Piaget Society, Biology and Knowledge Revisited focuses on the classic issue of the relationship between nature and nurture in cognitive and linguistic development, and their neurological substrates. Contributors trace the history of ideas concerning the relationship between evolution and development, and bring powerful new conceptual systems and research data to bear on understanding the problem of experience-contingent brain development and evolution. They focus on processes of phenotype construction - which fill the gap between genes and behavior - and demonstrate that evolutionary psychological models of innate mental modules are incompatible with what is known about these processes. This book presents exciting new approaches to the development and evolution of cognitive and linguistic abilities. Returning to the broad evolutionary theme of a previous meeting, the symposium focused on specifically constructivist approaches to neurogenesis and language acquisition, and their evolution. It was organized around ideas about the relationship between development and evolution raised in Piaget's books. Research in this arena has yielded cutting-edge insight into behavioral influences on brain plasticity. Two of its subthemes run throughout - a critique of modularity models popular among evolutionary psychologies and the prescient yet flawed nature of Piaget's critique of the modern synthesis of evolution. As a result, Biology and Knowledge Revisited is intended for developmental psychologists, psycholinguists, biological anthropologists, evolutionary psychologists, and philosophers of science.

As genetics becomes increasingly important in our everyday environment, misinterpretation of its scientific foundation leads to mixed feelings of hope and fear about the potential of its applications. Trajectories of Genetics uncovers the many facets of genetics - from humans to animals, plants, and the microscopic world through more than a century of scientific progress. It summarizes the evolution of ideas as the organization and functioning of genetic material has become clearer. The book analyzes how genetic information transmitted from generation to generation in nucleic acids enables the fulfillment of biological functions and the evolution of the living world. It illustrates current developments in many areas: the improvement of species of agronomic interest, an increased understanding of microbial worlds, the management of genetic pathologies and the synthesis of new forms of life.

Chemical reactions related to living beings are studied under biochemistry. As the name suggests both biology and chemistry are encompassed under this subject. It is the functions, composition and structure of the substances that make up a living organism. In this book, our focus will be on the chemical processes that are going on in the human body in particular. It is the study of the constituents of cells such as proteins, carbohydrates, lipids, nucleic acids, and other biomolecules, and also of their structure functions and transformations that occuring during a life process.

Major inconsistencies in Darwin's theory of the origin of species by natural selection remained unresolved for over a century until the results of recent research in various genome projects led to the theory's reinterpretation. Reviewing this new information, Donald Forsdyke, a laboratory scientist involved in genome research, wondered whether similar discoveries could have been made a century earlier, by one of Darwin's contemporaries. The Origin of Species Revisited describes his investigation into the history of evolutionary biology and its startling conclusion. The trail led first to Joseph Hooker and Thomas Huxley, who had been both the theory's strongest supporters and its most penetrating critics, and eventually to the Victorian George Romanes and Darwin's young research associate William Bateson. Although these men were well-known, their resolution of the origin of species paradox has either been ignored (Romanes), or ignored and reviled (Bateson). Four years after Darwin's death, Romanes published a theory of the origin of species by means of "physiological selection" that resolved the inconsistencies in Darwin's theory and introduced the idea of a "peculiarity" of the reproductive system that allowed selective fertility between "physiological complements." Forsdyke argues that the chemical basis of the origin of species by physiological selection is actually the species-dependent component of the base composition of DNA, showing that Romanes thus anticipated modern biochemistry. Using this new perspective Forsdyke considers some of the outstanding problems in biology and medicine, including the question of how "self" is distinguished from "not-self" by members of different species. Finally he examines the political and ideological forces that led to Romanes' contribution to evolutionary biology remaining unappreciated until now.

Although interest in evolutionary novelties can be that these different mechanisms cooperate in the mak traced back to the time of Darwin, the appreciation ing of new genes. In the second phase of new gene evolution, conventional models of new gene evolution, and systematical experimental pursuit of the origin and evolution of new gene functions did not appear for example by gene duplication, held that the muta until the early years of last decade. Since the 1970s, tions fixed in the early stages of the new genes are Susumu Ohno, Walter Gilbert, and others from the assumed to be neutral or nearly neutral. However, it area of evolutionary genetics have made pioneer ef appears that the force of Darwinian positive selection has been detectably strong from the outset in avail forts to elaborate possibilities for major biological mechanisms, for example, gene duplication and exon able population genetic studies of young genes created through the process of exon recombination. This may shuffling, by which new gene functions could arise. However, the problem of new gene evolution did not account for a common phenomenon in phylogenetic catch significant attention among biologists generally analyses of genes with changed functions: the early even recently. One of the reasons was the lack of ex stages of such genes are usually associated with accel perimental or observational systems for investigating erated substitution rates. Nonetheless, a more general factual details of the 'birth' process of new genes.

This book provides a review of biochemistry as an algebra of molecules of living matter and utilizes Clifford algebras to discuss the basic biochemical processes of DNA replication, DNA transcription, RNA splicing and translation. Viral carcinogenesis is discussed in depth, specific attention is paid to the structural features of biomolecules that

ENDOCRINOLOGY, edited by J. Larry Jameson, MD, PhD and Leslie J. De Groot, MD, has been considered the definitive source in its field for decades. Now this landmark reference has been exhaustively updated to bring you the latest clinical guidance on all aspects of diagnosis and treatment for the full range of endocrine and metabolism disorders, including new information on diabetes, obesity, MEN I and II, disorders of sex determination, and pituitary tumors. Entirely new chapters on Lipodystrophy Syndromes, Lipoprotein Metabolism, and Genetic Disorders of Phosphate Homeostasis keep you well informed on today’s hot topics. You’ll benefit from unique, global perspectives on adult and pediatric endocrinology prepared by an international team of renowned authorities. This reference is optimally designed to help you succeed in your demanding practice and ensure the best possible outcomes for every patient. Overcome virtually any clinical challenge with detailed, expert coverage of every area of endocrinology, authored by hundreds of leading luminaries in the field. Provide state-of-the-art care with comprehensive updates on diabetes, obesity, MEN I and II, disorders of sex determination, and pituitary tumors ... brand-new chapters on Lipodystrophy Syndromes, Lipoprotein Metabolism, and Genetic Disorders of Phosphate Homeostasis ... expanded coverage of sports performance, including testosterone, androgen research, and bone growth and deterioration ... and the newest discoveries in genetics and how they affect patient care. Make the best clinical decisions with an enhanced emphasis on evidence-based practice in conjunction with expert opinion. Rapidly consult with trusted authorities thanks to new expert-opinion treatment strategies and recommendations. Zero in on the most relevant and useful references with the aid of a more focused, concise bibliography. Locate information more quickly, while still getting the complete coverage you expect.

Efforts to increase efficient nutrient use by crops are of growing importance as the global demand for food, fibre and fuel increases and competition for resources intensifies. The Molecular and Physiological Basis of Nutrient Use Efficiency in Crops provides both a timely summary of the latest advances in the field as well as anticipating directions for future research. The Molecular and Physiological Basis of Nutrient Use Efficiency in Crops bridges the gap between agronomic practice and molecular biology by linking underpinning molecular mechanisms to the physiological and agronomic aspects of crop yield. These chapters provide an understanding of molecular and physiological mechanisms that will allow researchers to continue to target and improve complex traits for crop improvement. Written by leading international researchers, The Molecular and Physiological Basis of Nutrient Use Efficiency in Crops will be an essential resource for the crop science community for years to come. Special Features: coalesces current knowledge in the areas of efficient acquisition and utilization of nutrients by crop plants with emphasis on modern developments addresses future directions in crop nutrition in the light of changing climate patterns including temperature and water availability bridges the gap between traditional agronomy and molecular biology with focus on underpinning molecular mechanisms and their effects on crop yield includes contributions from a leading team of global experts in both research and practical settings