Although as part of my general plan, this book is a continua tion of my earlier monograph "Protein Biosynthesis and Problems of Ontogenesis,"* published in 1963, in all other respects it is an independent work. The earlier monograph was devoted to the analysis of many of the aspects of the problem of protein biosynthesis, and problems of inheritance and development were discussed only insofar as they are derivatives of the problems of biosynthesis. The complex act of protein biosynthesis, comprising autore production of the genetic material (DNA), formation of the templates of protein synthesis (messenger RNA), synthesis of amino acid carriers (transfer RNA), formation of ribosomes and polysomes, activation of amino acids, and so on, was examined in the previous monograph not merely from the standpoint of interaction between the components of this system, but also from that of their mani festation in actual biological systems during morphogenesis and aging of the organism. However, both morphogenesis and aging were investigated very generally, Simply as models, without any detailed analysis of their specific features and complexity. The present book is therefore a logical continuation of its prede cessor. It rests largely on a comprehensive analysis of the molecular-genetic and biochemical aspects of development and differentiation of living organisms, and questions of protein biosyn thesis are discussed briefly and generally, and only so far as is necessary for fulfillment of the primary task. • Zh. A. Medvedev. 1966. Protein Biosynthesis and Problems of Heredity. Developement.

Molecular Genetic Mechanisms in Development and Aging discusses the mechanisms of aging at the level of the genome. This book explores the fundamental knowledge concerning the regulation and expression of gene, which is derived from investigations on microbial organisms. Organized into nine chapters, this book starts with an overview of the molecular genetic basis for the processes of aging. This text then explores the highly complex multicellular members of the class Insecta, which provide the researcher with many distinct and unique advantages for aging studies. Other chapters discuss the mechanisms of genetic control and organization during the development and aging of eukaryotes, which pose some challenging problems in cellular and developmental biology. The final chapter deals with the limitations of previous studies, including the lack of comparability due to differences in techniques, the measuring of free amino acid titers in hemolyph only, and differing diet and environmental variations. Biologists and students interested in developmental and molecular genetics will find this book useful.

Gender (sex) is a set of morphological and physiological characteristics of the organism underlying sexual reproduction, the essence of which is reduced to fertilization, i.e. the fusion of male and female gametes (gametes) zygote, which develops into a new organism.Sexual reproduction of a species is considered as one of the mechanisms of its homeostasis. Thanks to this mechanism, numerous species have an evolutionary advantage. In the book, two authors will discuss the types of genetic sex determination and differentiation, mostly in multicellular animal organisms. Sex determination is both genetic and environmental process, the sex of an individual being established through an alternative physiological solution. There are two main postulated mechanisms of sex determination: genetic (GSD, Genetical Sex Determination) and environmental (ESD, Environmental Sex Determination).

This book provides a fascinating account of the accumulated knowledge of the mechanisms by which plants regulate their patterning. This is an exciting subject based on a novel endeavor, not least due to the rapid progress made in recent years in the diverse fields of genetics, molecular biology, microscopy, inter- and intracellular signaling, as well as our intimate knowledge of model plants (such as Arabidopsis).This book is unique in that it provides, in one volume, comprehensive information on all the main organs of flowering plants. There is no other book similar to this, written by a single author, that has been published in the last 10 years.The book contains updated information on the differentiation of the plant organs with respect to structure and molecular genetics, and the methodologies employed to investigate plant patterning are described in detail. Extensively illustrated with numerous figures, many of which are in color, the book will appeal to three main groups of readers: novices interested in plant patterning; plant biologists requiring a comprehensive understanding of differentiation in flowering plants; and graduate students in advanced courses.

Human Molecular Genetics has been carefully crafted over successive editions to provide an authoritative introduction to the molecular aspects of human genetics, genomics and cell biology. Maintaining the features that have made previous editions so popular, this fifth edition has been completely updated in line with the latest developments in the field. Older technologies such as cloning and hybridization have been merged and summarized, coverage of newer DNA sequencing technologies has been expanded, and powerful new gene editing and single-cell genomics technologies have been added. The coverage of GWAS, functional genomics, stem cells, and disease modeling has been expanded. Greater focus is given to inheritance and variation in the context of populations and on the role of epigenetics in gene regulation. Key features: Fully integrated approach to the molecular aspects of human genetics, genomics, and cell biology Accessible text is supported and enhanced throughout by superb artwork illustrating the key concepts and mechanisms Summary boxes at the end of each chapter provide clear learning points Annotated further reading helps readers navigate the wealth of additional information in this complex subject and provides direction for further study Reorganized into five sections for improved access to related topics Also new to this edition – brand new chapter on evolution and anthropology from the authors of the highly acclaimed Human Evolutionary Genetics A proven and popular textbook for upper-level undergraduates and graduate students, the new edition of Human Molecular Genetics remains the ‘go-to’ book for those studying human molecular genetics or genomics courses around the world.

Molecular Genetic Medicine, Volume III, summarizes progress in several of the most important areas of modern molecular genetics and medicine. The book opens with a chapter on the birth and early development of the field of human gene therapy and the earliest conceptual and technical descriptions of the issues and opportunities in this new area of medicine. This is followed by separate chapters on the gene responsible for cystic fibrosis; interactions and genetic phenomena that accompany the progression of astrocytic tumors; and molecular biology of Alzheimer's disease; and the search for the Huntington's disease gene and the role of genetic instability in this disease. The final chapter discusses the ways in which both the medical insurance and genetics industries will have to respond to changes in the power of genetic information and its ability to predict coronary vascular disease, cancer, neurological disease, and all the other common afflictions that constitute the bulk of their businesses.

The importance of epigenetic regulation of gene expression, particularly in higher organisms, is now clear and the 2004 Cold Spring Harbor Annual Symposium provided many new examples as well as insights into the underlying mechanisms. The resulting volume—with over 60 papers from experts across the field—covers various aspects of nuclear organization and dynamics; genomic imprinting, chromosomal inactivation, and other examples of gene silencing; the histone and DNA modifications associated with these conditions; and the roles of RNA and protein regulators in establishing and maintaining these states.