NAFLD and NASH refer to the hepatic phenotype of metabolic syndromes strongly associated with obesity, diabetes, and dyslipidemia. NAFLD and NASH have complex pathogenesis modulated not only by the liver but also by muscle, adipose tissue, pancreas, gut microbiome, and immune and central nervous systems. This complex pathology, coupled with insulin resistance, lipid and bile acid changes, and congenital genetic predisposition, induces liver injury due to oxidative stress, endoplasmic reticulum stress, and autophagy dysfunction. Additionally, NAFLD and NASH contribute to diseases such as cirrhosis, atherosclerosis, chronic kidney disease, lung disease, and cancer in various organs, leading to systemic multi-organ damage. Even though enthusiastic development of new drugs for NAFLD and NASH has been underway, we are still lacking progress in generating therapeutic agents based on multiorgan-related pathomechanisms. In this special issue, we welcome clinical and basic studies on extrahepatic lesions as well as new findings related to liver pathology in NAFLD and NASH. Topic Editors welcome manuscripts particularly focusing on new therapies and new signaling pathways on the multiorgan-linkage of NAFLD and NASH.

This open access book is supported by the European Atherosclerosis Society Association (EAS). This follow-up edition of the well-received Handbook volume 'Atherosclerosis: Diet and Drugs' reflects the state-of-the-art and most recent developments in atherosclerosis research. Outstanding international experts give a comprehensive overview of the field covering topics, such as improving the treatment focusing on established targets, novel drug developments addressing pre-defined targets, hypothesis-based and hypothesis-free approaches to unravel novel targets.

Since its first publication more than 35 years ago, MacSween’s Pathology of the Liver, by Drs. Alastair D. Burt, Linda D. Ferrell, and Stefan G. Hübscher, has established itself as the definitive reference on liver pathology. The 7th Edition continues the tradition of excellence with more than 1,000 high-quality illustrations, coverage of the new and emerging diagnostic applications and techniques that pathologists must be familiar with, an up-to-date review of drug-induced injury, and much more. A must-have for every surgical pathologist, MacSween’s remains the most authoritative and comprehensive book in its field. Provides comprehensive, state-of-the-art coverage of all malignant and benign hepatobiliary disorders from an international "who’s who" in the field. Helps you quickly recognize the wide variety of liver appearances that result from infections, tumors, and tumor-like lesions, as well as organ damage caused by drugs and toxins. Features 1,000+ full-color illustrations that provide a complete visual guide to each tumor or tumor-like lesion and assist in the recognition and diagnosis of any tissue sample you’re likely to encounter. Incorporates relevant data from ancillary techniques (immunohistochemistry, cytogenetics, and molecular genetics), giving you the tools required to master the latest breakthroughs in diagnostic technology. Includes an updated chapter on mechanisms of liver disease, including coverage of regression and remodeling of disease and new information on next generation sequencing; an up-to-date review of drug-induced injury, including the effects of herbal and alternative medicines. Expert ConsultTM eBook version included with purchase. This enhanced eBook experience allows you to search all of the text, figures, Q&As, and references from the book on a variety of devices.

Present Knowledge in Nutrition, Eleventh Edition, provides an accessible, highly readable, referenced, source of the most current, reliable, and comprehensive information in the broad field of nutrition. Now broken into two, separate volumes, and updated to reflect scientific advancements since the publication of its tenth edition, Present Knowledge in Nutrition, Eleventh Edition includes expanded coverage on the topics of basic nutrition and metabolism and clinical and applied topics in nutrition. This volume, Present Knowledge in Nutrition: Clinical and Applied Topics in Nutrition, addresses life stage nutrition and maintaining health, nutrition monitoring, measurement, and regulation, and important topics in clinical nutrition. Authored by an international group of subject-matter experts, with the guidance of four editors with complementary areas of expertise, Present Knowledge in Nutrition, Eleventh Edition will continue to be a go-to resource for advanced undergraduate, graduate and postgraduate students in nutrition, public health, medicine, and related fields; professionals in academia and medicine, including clinicians, dietitians, physicians, and other health professionals; and academic, industrial and government researchers, including those in nutrition and public health. The book was produced in cooperation with the International Life Sciences Institute (https://ilsi.org/). - Provides an accessible source of the most current, reliable and comprehensive information in the broad field of nutrition - Features new chapters on topics of emerging importance, including the microbiome, eating disorders, nutrition in extreme environments, and the role of nutrition and cognition in mental status - Covers topics of clinical relevance, including the role of nutrition in cancer support, ICU nutrition, supporting patients with burns, and wasting, deconditioning and hypermetabolic conditions

Extensively revised with new illustrations, new clinical photos, this classic text remains the most comprehensive and up-to-date resource on surgery of the hepatobiliary and pancreatic region. Dr. William Jarnagin and his team of internationally recognized surgeons continue the Blumgart’s tradition of excellence, bringing you the latest advances in diagnostic and surgical techniques. You’ll find updates on the newest minimally invasive surgeries, new interventional diagnostic techniques, and complete coverage of all relevant diseases, including those seen in the tropics. Considers all worldwide opinions and approaches to management, and includes key data on surgical outcomes to better inform your clinical decision-making. Covers exactly what you need to know, balancing basic science with information on clinical practice. Presents cutting edge guidance on pathology, diagnostics, surgery and non-operative intervention of the liver, biliary tract, and pancreas in a single, comprehensive reference. Covers the most recent non-surgical therapies for pancreatic cancer, microwave ablation, and other emerging technologies. Brings you up to date with recent developments in transplantation, minimally invasive surgery, percutaneous devices, pre- and post-care, blood transfusion, and surgical techniques for the spleen. Features an extensively revised art and illustration program, with new anatomical line drawings (including hundreds now in color), more than 750 new clinical photos, more schematic diagrams that summarize information, and new graphs and algorithms throughout.