Ecotoxiclogical risk from multiple stressors covers any situation where org- isms are exposed to a combination of environmental stressors. These include physical and chemical pollutants as well as other stressors such as parasites and environmental impact (e. g. , climate change or habitat loss). The combi- tion of stressors can result in increased risk to organisms (either additive or synergistic effects) or decreased effects (protective or antagonistic effects). The multiple stressor challenge is an international, multi-disciplinary problem requiring an international, multi-disciplinary approach. The c- rent approach to multiple stressors is to examine one stressor at a time and assume additivity. Little work has been done on combinations of stressors such that potential interactions can be determined. The problem is very complex. Multiple stressors pose a whole spectrum of challenges that range from basic science to regulation, policy and gove- ance. The challenges raise fundamental questions about our understanding of the basic biological response to stressors, as well as the implications of those uncertainties in environmental risk assessment and management. In addition to the great breadth, there is also great depth in the research ch- lenges, largely due to the complexity of the issues. From a basic science point of view, many of the mechanisms and processes under investigation are at the cutting edge of science — involving new paradigms such as genomic ins- bility and bystander effects.

There is a pressing need for developing and testing a general set of theories in order to provide a confident basis for prediction of multiple stressor effects. Confident prediction is central to confident decision making in water pollution control. Consequently, WERF commissioned this study, which has as its goal to provide a study design based on good science that helps establish a general, conceptual approach to multiple stressors. The objectives addressed in this report are: (1) review and critique the existing body of knowledge for multiple stressors; (2) develop a searchable, annotated bibliography of multiple stressor research; and, (3) identify gaps in the body of knowledge. A rigorous, theoretical basis for the prediction of multiple stressor effects could not be developed from the literature on experimental studies of multiple stressor effects in aquatic ecosystems. Despite the wealth of observational data, the existence of several useful tools for interpretation of cause/effect relationships (including formal Stressor Identification methods), and the studies reviewed in this report, there are no tools that allow a confident, a priori, prediction of ecosystem response to multiple stressors. The current literature provides, at best, a series of site-specific glimpses of the response of ecological communities and ecosystems to multiple stressors. There is seldom, if ever, any reference to a more generalized model of multiple stressor effects apart from the discussion of the expectations regarding additivity versus synergism. Many articles that purport to be multiple stressor studies do not go beyond an inventory of the various stresses and upsets affecting the ecosystem, without attempting to assess the interactions among them.

This book explains how stress – either psychological or physical – can activate and/or paralyse human innate or adaptive immunity. Adequate immunity is crucial for maintaining health, both on Earth and in space. During space flight, human physiology is specifically challenged by complex environmental stressors, which are most pronounced during lunar or interplanetary missions. Adopting an interdisciplinary approach, the book identifies the impact of these stressors – the space exposome – on immunity as a result of (dys-)functions of specific cells, organs and organ networks. These conditions (e.g. gravitation changes, radiation, isolation/confinement) affect immunity, but at the same time provide insights that may help to prevent, diagnose and address immune-related health alterations. Written by experts from academia, space agencies and industry, the book is a valuable resource for professionals, researchers and students in the field of medicine, biology and technology. The chapters “The Impact of Everyday Stressors on the Immune System and Health”, “Stress and Radiation Responsiveness” and “Assessment of Radiosensitivity and Biomonitoring of Exposure to Space adiation” are available open access under a Creative Commons Attribution 4.0 International License via link.springer.com.

In the last 50 years, classical breeding has played a significant role in achieving higher crop productivity, but major crops have reached a plateau in their yield potential. Therefore, the current focus for sustainable intensification of agriculture is the use of biotechnological approaches to enhance the yield potential by combating the yield losses that occur due to abiotic stresses. The abiotic stresses are governed by multigenes, and therefore, a holistic approach is needed to get success in imparting stress tolerance to enhance the yield potential of our crops. Plants face multiple stress conditions during their life stages and adopt several physiological, biochemical, and molecular strategies to combat that, which are sometimes not sufficient to survive, particularly crop plants. The climate change era has created a need to understand the abiotic stresses in a holistic way. Therefore, a deep understanding of multiple abiotic stress mechanisms is necessary to develop crops tolerant to climate fluctuation. With this background, the outline of this book covers the following features: • Agriculture sustainability and molecular understanding of multiple stress tolerance • Systems biology for life-history strategies, conventional and genomic approaches above and underground • Genetic resources and molecular understanding of seed priming • Molecular signaling compounds, cell signal transduction, and crosstalk between plant growth hormones and regulators • Roles Transcription factors, LEA proteins, reactive oxygen species and alternative oxidase • Genome editing, metabolomics, and ‘omics’ technologies

This book presents an inclusive approach to deal with plant stresses in light of recent technological advances. As we have entered into a new decade, researchers and scientists should review and evaluate the recent findings in the field of plant stress management and visualize what we need to focus upon in the near future to increase crop yield. Above all, global climate changes present the greatest challenges of all time for plant scientists. In this context, the book highlights the recent findings and future perspectives in crop improvement to the faculties, scientists, research scholars, and postgraduate students. Major features of the book include an inclusive approach in understanding the mechanism of stress tolerance; recent advances and innovations in the field of allied disciplines like microbiology, molecular biology, biotechnology, plant breeding, nanobiotechnology, etc., for improving plant stress tolerance; and illustrative sketches to convey the mechanism and strategies of stress alleviation.

In the industrial era, the most important potential threat to crop production is abiotic stress, including toxic metal/metalloid stress. Growing populations and rapid industrialization lead to the generation and release of huge amounts of toxic metals/metalloids into the environment, altering plant physiological processes and reducing yields. In the last few decades, there has been extensive research to elucidate the mechanisms of tolerance to metal/metalloid toxicity and ways to improve the defense system in plants. Use of exogenous photoprotectants such as osmoprotectants, plant nutrients, phytohormones, signaling molecules, antioxidants, amino acids and organic acids are widely being used to improve plants’ tolerance to metal/metalloid stress. Recently, phytoremediation approaches have been effectively employed to remediate metal/metalloid pollution. This book presents the latest insights into plant responses and tolerance in plants grown under metal/metalloids stress to provide a better understanding of the topic and the future outlook.

Stress of either psychological or physical nature can activate and/or paralyse humans’ innate and adaptive immunity. However, adequate immunity is crucial to the maintenance of health on earth and in space. During space flight, human physiology and health are challenged by complex environmental stressors which might be at their most pronounced during lunar or interplanetary missions. While previous publications have addressed the physiological changes that occur during space flight, this book goes further, by adopting an interdisciplinary approach to analyze the complex interaction of living conditions in space, the immune system, and astronauts’ health. It is explained how such analysis of the consequences of stress for the immune system may help in preventing, diagnosing, and counteracting immune-related alterations in health on earth as well as in space

Common Pediatric Diseases: Current Challenges provides an update on different diseases and problems that affect child and adolescent health. The book starts with a quick introduction to challenges in the field of pediatrics and child health. This is followed by chapters on the outcomes of sexting, the integrated care of children with neurodevelopmental disorders, the influence of non-genetic transgenerational inheritance on children and adolescents’ development and the approach to pediatric genetic epilepsy. Additional topics covered in the book include the medical and social outcomes of cardiac diseases along with a review on specific aspects of fetal and neonatal medicine (meconium-stained newborns, transient tachypnea of newborns and fetal tumors). The book also features a chapter on Autism Spectrum Disorder during infancy and its early symptoms. The concluding chapter covers medical futility controversies and end-of-life care. Audience Medical students; residents and clinicians in pediatrics